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SAMD11 sterile alpha motif domain containing 11 [ Homo sapiens (human) ]

Gene ID: 148398, updated on 12-Aug-2022

Summary

Official Symbol
SAMD11provided by HGNC
Official Full Name
sterile alpha motif domain containing 11provided by HGNC
Primary source
HGNC:HGNC:28706
See related
Ensembl:ENSG00000187634 MIM:616765; AllianceGenome:HGNC:28706
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRS
Summary
Predicted to enable several functions, including histone binding activity; protein domain specific binding activity; and protein self-association. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 7.4), endometrium (RPKM 5.9) and 25 other tissues See more
Orthologs
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Genomic context

See SAMD11 in Genome Data Viewer
Location:
1p36.33
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (923923..944574)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (353566..373316)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (859303..879954)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 41 member C Neighboring gene tubulin beta 8 class VIII pseudogene 11 Neighboring gene uncharacterized LOC284600 Neighboring gene collagen alpha-1(III) chain-like Neighboring gene long intergenic non-protein coding RNA 2593 Neighboring gene NOC2 like nucleolar associated transcriptional repressor Neighboring gene kelch like family member 17 Neighboring gene pleckstrin homology domain containing N1 Neighboring gene PPARGC1 and ESRR induced regulator, muscle 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC45873

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sterile alpha motif domain-containing protein 11
Names
SAM domain-containing protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385640.1NP_001372569.1  sterile alpha motif domain-containing protein 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL645608
    UniProtKB/TrEMBL
    A0A087WX24
    Related
    ENSP00000480678.2, ENST00000618323.5
    Conserved Domains (2) summary
    cd09579
    Location:704771
    SAM_Samd7,11; SAM domain of Samd7,11 subfamily of Polycomb group
    pfam01342
    Location:113185
    SAND; SAND domain
  2. NM_001385641.1NP_001372570.1  sterile alpha motif domain-containing protein 11 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645608
    UniProtKB/TrEMBL
    A0A087WU74
    Related
    ENSP00000478421.2, ENST00000616016.5
    Conserved Domains (2) summary
    cd09579
    Location:703770
    SAM_Samd7,11; SAM domain of Samd7,11 subfamily of Polycomb group
    pfam01342
    Location:113185
    SAND; SAND domain
  3. NM_152486.4NP_689699.3  sterile alpha motif domain-containing protein 11 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL645608
    Consensus CDS
    CCDS2.2
    UniProtKB/Swiss-Prot
    Q8TB59
    Related
    ENSP00000342313.3, ENST00000342066.8
    Conserved Domains (1) summary
    cd09579
    Location:540607
    SAM_Samd7,11; SAM domain of Samd7,11 subfamily of Polycomb group

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    923923..944574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    353566..373316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)