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CREB3L4 cAMP responsive element binding protein 3 like 4 [ Homo sapiens (human) ]

Gene ID: 148327, updated on 13-Mar-2020

Summary

Official Symbol
CREB3L4provided by HGNC
Official Full Name
cAMP responsive element binding protein 3 like 4provided by HGNC
Primary source
HGNC:HGNC:18854
See related
Ensembl:ENSG00000143578 MIM:607138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JAL; hJAL; ATCE1; CREB3; CREB4; AIBZIP
Summary
This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Broad expression in prostate (RPKM 52.3), stomach (RPKM 10.0) and 20 other tissues See more
Orthologs

Genomic context

See CREB3L4 in Genome Data Viewer
Location:
1q21.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (153967487..153974364)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153940315..153946840)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CREB regulated transcription coactivator 2 Neighboring gene solute carrier family 39 member 1 Neighboring gene microRNA 6737 Neighboring gene jumping translocation breakpoint Neighboring gene RAB13, member RAS oncogene family Neighboring gene ribosomal protein S27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
endoplasmic reticulum unfolded protein response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cyclic AMP-responsive element-binding protein 3-like protein 4
Names
CREB-4
androgen-induced basic leucine zipper protein
attaching to CRE-like 1
cAMP responsive element binding protein 1
cAMP-responsive element-binding protein 3-like protein 4
cAMP-responsive element-binding protein 4
cyclic AMP-responsive element-binding protein 4
tisp40
transcript induced in spermiogenesis protein 40

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001255978.2NP_001242907.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001242907.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AY049977, DB012316
    Consensus CDS
    CCDS1056.1
    UniProtKB/Swiss-Prot
    Q8TEY5
    Related
    ENSP00000357596.3, ENST00000368607.8
    Conserved Domains (2) summary
    TIGR00864
    Location:77154
    PCC; polycystin cation channel protein
    cd14689
    Location:218278
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
  2. NM_001255979.2NP_001242908.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001242908.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA652478, AF394167, AF468007
    Consensus CDS
    CCDS1056.1
    UniProtKB/Swiss-Prot
    Q8TEY5
    Related
    ENSP00000357592.1, ENST00000368603.5
    Conserved Domains (2) summary
    TIGR00864
    Location:77154
    PCC; polycystin cation channel protein
    cd14689
    Location:218278
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
  3. NM_001255980.2NP_001242909.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001242909.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1. Variants 4 and 5 encode the same protein.
    Source sequence(s)
    AA652478, AK304665, DB012316
    Consensus CDS
    CCDS58029.1
    UniProtKB/Swiss-Prot
    Q8TEY5
    Conserved Domains (1) summary
    cd14689
    Location:198258
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
  4. NM_001255981.2NP_001242910.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001242910.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1. Variants 4 and 5 encode the same protein.
    Source sequence(s)
    AL358472, BX647716
    Consensus CDS
    CCDS58029.1
    UniProtKB/Swiss-Prot
    Q8TEY5
    Related
    ENSP00000357589.3, ENST00000368600.7
    Conserved Domains (1) summary
    cd14689
    Location:198258
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
  5. NM_130898.4NP_570968.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_570968.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AA652478, AB052778, DB012316
    Consensus CDS
    CCDS1056.1
    UniProtKB/Swiss-Prot
    Q8TEY5
    Related
    ENSP00000271889.4, ENST00000271889.8
    Conserved Domains (2) summary
    TIGR00864
    Location:77154
    PCC; polycystin cation channel protein
    cd14689
    Location:218278
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain

RNA

  1. NR_045658.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA652478, AK297703, BF681098, DB012316

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    153967487..153974364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453343.1XP_024309111.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

    Conserved Domains (2) summary
    TIGR00864
    Location:77154
    PCC; polycystin cation channel protein
    cd14689
    Location:218278
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
  2. XM_024453344.1XP_024309112.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

    Conserved Domains (2) summary
    TIGR00864
    Location:77154
    PCC; polycystin cation channel protein
    cd14689
    Location:218278
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
  3. XM_017000372.1XP_016855861.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q8TEY5
    Conserved Domains (1) summary
    cd14689
    Location:198258
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
  4. XM_006711172.2XP_006711235.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006711235.1

    UniProtKB/Swiss-Prot
    Q8TEY5
    Conserved Domains (1) summary
    cd14689
    Location:198258
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
  5. XM_024453346.1XP_024309114.1  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1

    Conserved Domains (2) summary
    TIGR00864
    Location:77154
    PCC; polycystin cation channel protein
    cd14689
    Location:218278
    bZIP_CREB3; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 3 (CREB3) and similar proteins: a DNA-binding and dimerization domain
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