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Grpr gastrin releasing peptide receptor [ Mus musculus (house mouse) ]

Gene ID: 14829, updated on 8-Feb-2024

Summary

Official Symbol
Grprprovided by MGI
Official Full Name
gastrin releasing peptide receptorprovided by MGI
Primary source
MGI:MGI:95836
See related
Ensembl:ENSMUSG00000031364 AllianceGenome:MGI:95836
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GRP-R
Summary
This gene encodes a multipass membrane protein that functions as a receptor for gastrin releasing peptide. Signalling through this receptor is important in a variety of physiological processes, including responses to itching, satiety, and fear. [provided by RefSeq, May 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Grpr in Genome Data Viewer
Location:
X F5; X 75.63 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (162296900..162332732, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (163513904..163549736, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48230 Neighboring gene STARR-seq mESC enhancer starr_48231 Neighboring gene predicted gene, 26007 Neighboring gene fusion, derived from t(12;16) malignant liposarcoma pseudogene Neighboring gene STARR-seq mESC enhancer starr_48232 Neighboring gene ring finger protein 138, retrogene 1 Neighboring gene uncharacterized protein C8orf59 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC130509

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled peptide receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables bombesin receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables neuropeptide binding ISO
Inferred from Sequence Orthology
more info
 
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables neuropeptide receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gastrin-releasing peptide receptor
Names
GRP-preferring bombesin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008177.3NP_032203.1  gastrin-releasing peptide receptor

    See identical proteins and their annotated locations for NP_032203.1

    Status: REVIEWED

    Source sequence(s)
    AK033473, AL670292
    Consensus CDS
    CCDS30512.1
    UniProtKB/Swiss-Prot
    P21729, Q53WV4
    Related
    ENSMUSP00000033730.3, ENSMUST00000033730.3
    Conserved Domains (1) summary
    pfam00001
    Location:58321
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    162296900..162332732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)