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Hspa5 heat shock protein 5 [ Mus musculus (house mouse) ]

Gene ID: 14828, updated on 22-Jan-2023

Summary

Official Symbol
Hspa5provided by MGI
Official Full Name
heat shock protein 5provided by MGI
Primary source
MGI:MGI:95835
See related
Ensembl:ENSMUSG00000026864 AllianceGenome:MGI:95835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bip; Sez7; mBiP; Grp78; SEZ-7; Hsce70; baffled; D2Wsu17e; D2Wsu141e
Summary
Enables misfolded protein binding activity and ribosome binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; cerebellum development; and positive regulation of protein ubiquitination. Acts upstream of or within several processes, including cellular response to interleukin-4; negative regulation of transforming growth factor beta receptor signaling pathway; and toxin transport. Located in several cellular components, including cell surface; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and musculoskeletal system. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 321.6), genital fat pad adult (RPKM 154.1) and 28 other tissues See more
Orthologs
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Genomic context

See Hspa5 in Genome Data Viewer
Location:
2 B; 2 22.94 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34662102..34666541)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (34772090..34776529)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 34372 Neighboring gene DnaJ (Hsp40) homolog, subfamily B, member 6 pseudogene Neighboring gene GTPase activating protein and VPS9 domains 1 Neighboring gene Rab9 effector protein with kelch motifs Neighboring gene small nucleolar RNA U13 Neighboring gene F-box and WD-40 domain protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables misfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables misfolded protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within ER overload response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in IRE1-mediated unfolded protein response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to interleukin-4 IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to unfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cerebellar Purkinje cell layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebellum structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of protein localization in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of embryonic development TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in post-translational protein targeting to membrane, translocation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis involved in protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within toxin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of endoplasmic reticulum chaperone complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of endoplasmic reticulum chaperone complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of endoplasmic reticulum chaperone complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
endoplasmic reticulum chaperone BiP
Names
78 kDa glucose-regulated protein
GRP-78
HSP70 family protein 5
XAP-1 antigen
binding-immunoglobulin protein
glucose regulated protein, 78 kDa
heat shock 70 kDa protein 5
heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
heat shock protein 70 family protein 5
heat shock protein family A member 5
immunoglobulin heavy chain-binding protein
NP_001156906.1
NP_071705.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163434.1NP_001156906.1  endoplasmic reticulum chaperone BiP precursor

    See identical proteins and their annotated locations for NP_001156906.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK148539, AL929106
    Consensus CDS
    CCDS15950.1
    UniProtKB/Swiss-Prot
    P20029, Q61630
    UniProtKB/TrEMBL
    A0A6P5QRW0, A0A8C6H8H9
    Related
    ENSMUSP00000028222.7, ENSMUST00000028222.13
    Conserved Domains (1) summary
    pfam00012
    Location:31636
    HSP70; Hsp70 protein
  2. NM_022310.3NP_071705.3  endoplasmic reticulum chaperone BiP precursor

    See identical proteins and their annotated locations for NP_071705.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK152521, AL929106
    Consensus CDS
    CCDS15950.1
    UniProtKB/Swiss-Prot
    P20029, Q61630
    UniProtKB/TrEMBL
    A0A6P5QRW0, A0A8C6H8H9, Q3U7T8
    Related
    ENSMUSP00000097747.3, ENSMUST00000100171.3
    Conserved Domains (1) summary
    pfam00012
    Location:31636
    HSP70; Hsp70 protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    34662102..34666541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)