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ZNF98 zinc finger protein 98 [ Homo sapiens (human) ]

Gene ID: 148198, updated on 13-May-2022

Summary

Official Symbol
ZNF98provided by HGNC
Official Full Name
zinc finger protein 98provided by HGNC
Primary source
HGNC:HGNC:13174
See related
Ensembl:ENSG00000197360 MIM:603980; AllianceGenome:HGNC:13174
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
F7175; ZNF739
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 2.3), kidney (RPKM 0.7) and 13 other tissues See more
Orthologs
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Genomic context

See ZNF98 in Genome Data Viewer
Location:
19p12
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (22391019..22422346, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (22529651..22560967, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (22573821..22605148, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372330 Neighboring gene ribosomal protein L34 pseudogene 34 Neighboring gene uncharacterized LOC105376917 Neighboring gene BCL2 interacting protein 3 pseudogene 32 Neighboring gene BCL2 interacting protein 3 pseudogene 33

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
EBI GWAS Catalog
Genome-wide association scan of dental caries in the permanent dentition.
EBI GWAS Catalog
GWAS of dental caries patterns in the permanent dentition.
EBI GWAS Catalog

General gene information

Markers

Homology

Clone Names

  • MGC129634

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 98
Names
zinc finger protein 739
zinc finger protein F7175

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098626.2NP_001092096.1  zinc finger protein 98

    See identical proteins and their annotated locations for NP_001092096.1

    Status: VALIDATED

    Source sequence(s)
    AC011494, AC011516
    Consensus CDS
    CCDS46031.1
    UniProtKB/Swiss-Prot
    A6NK75
    Related
    ENSP00000350418.4, ENST00000357774.9
    Conserved Domains (6) summary
    smart00349
    Location:1373
    KRAB; krueppel associated box
    COG5048
    Location:179563
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:324344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:350372
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1352
    KRAB; KRAB box
    pfam13465
    Location:364389
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    22391019..22422346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    22529651..22560967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)