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Nr3c1 nuclear receptor subfamily 3, group C, member 1 [ Mus musculus (house mouse) ]

Gene ID: 14815, updated on 19-Sep-2021

Summary

Official Symbol
Nr3c1provided by MGI
Official Full Name
nuclear receptor subfamily 3, group C, member 1provided by MGI
Primary source
MGI:MGI:95824
See related
Ensembl:ENSMUSG00000024431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G; GR; Grl; Grl1; Grl-1
Expression
Ubiquitous expression in bladder adult (RPKM 11.2), subcutaneous fat pad adult (RPKM 8.1) and 28 other tissues See more
Orthologs
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Genomic context

See Nr3c1 in Genome Data Viewer
Location:
18 B3; 18 21.09 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (39543598..39652485, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (39410545..39519421, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (39570199..39646899, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 26 Neighboring gene uncharacterized LOC118567370 Neighboring gene predicted gene 15337 Neighboring gene predicted gene, 54019 Neighboring gene predicted gene, 30909 Neighboring gene predicted gene, 30961

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables glucocorticoid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adrenal gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucocorticoid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to steroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in chromatin-mediated maintenance of transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in glucocorticoid mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glucocorticoid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucocorticoid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucocorticoid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glucocorticoid receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular steroid hormone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maternal behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of glucocorticoid mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucocorticoid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of pri-miRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of pri-miRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of glucocorticoid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in response to arsenic-containing substance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glucocorticoid receptor
Names
glucocorticoid receptor 1
glucocorticoid receptor subtype P

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361209.1NP_001348138.1  glucocorticoid receptor

    Status: VALIDATED

    Source sequence(s)
    AC007995, AC124417
    Consensus CDS
    CCDS37791.1
    Related
    ENSMUSP00000111229.2, ENSMUST00000115567.8
    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  2. NM_001361210.1NP_001348139.1  glucocorticoid receptor

    Status: VALIDATED

    Source sequence(s)
    AC007995, AC124417
    Consensus CDS
    CCDS37791.1
    Related
    ENSMUSP00000111233.2, ENSMUST00000115571.8
    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  3. NM_001361211.1NP_001348140.1  glucocorticoid receptor

    Status: VALIDATED

    Source sequence(s)
    AC007995, AC124417
    Consensus CDS
    CCDS37791.1
    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  4. NM_001361212.1NP_001348141.1  glucocorticoid receptor

    Status: VALIDATED

    Source sequence(s)
    AC007995, AC124417
    Consensus CDS
    CCDS37791.1
    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  5. NM_008173.4NP_032199.3  glucocorticoid receptor

    See identical proteins and their annotated locations for NP_032199.3

    Status: VALIDATED

    Source sequence(s)
    AC007995, AC124417
    Consensus CDS
    CCDS37791.1
    UniProtKB/TrEMBL
    E9PUR6
    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    39543598..39652485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525658.3XP_006525721.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525721.1

    UniProtKB/TrEMBL
    E9PYV1
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  2. XM_006525662.3XP_006525725.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525725.1

    UniProtKB/TrEMBL
    E9PYV1
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  3. XM_030250339.2XP_030106199.1  glucocorticoid receptor isoform X2

    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  4. XM_006525664.3XP_006525727.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525727.1

    UniProtKB/TrEMBL
    E9PYV1
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  5. XM_006525659.5XP_006525722.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525722.1

    UniProtKB/TrEMBL
    E9PYV1
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  6. XM_036160990.1XP_036016883.1  glucocorticoid receptor isoform X2

    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  7. XM_030250338.2XP_030106198.1  glucocorticoid receptor isoform X2

    Related
    ENSMUSP00000025300.7, ENSMUST00000025300.13
    Conserved Domains (3) summary
    cd07076
    Location:546792
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433510
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  8. XM_006525661.4XP_006525724.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525724.1

    UniProtKB/TrEMBL
    E9PYV1
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  9. XM_006525663.5XP_006525726.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525726.1

    UniProtKB/TrEMBL
    E9PYV1
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  10. XM_006525665.5XP_006525728.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525728.1

    UniProtKB/TrEMBL
    E9PYV1
    Related
    ENSMUSP00000095199.3, ENSMUST00000097592.9
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
  11. XM_006525660.4XP_006525723.1  glucocorticoid receptor isoform X1

    See identical proteins and their annotated locations for XP_006525723.1

    UniProtKB/TrEMBL
    E9PYV1
    Conserved Domains (3) summary
    cd07076
    Location:547793
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:433511
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:27418
    GCR; Glucocorticoid receptor
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