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Grik3 glutamate receptor, ionotropic, kainate 3 [ Mus musculus (house mouse) ]

Gene ID: 14807, updated on 5-Jan-2023

Summary

Official Symbol
Grik3provided by MGI
Official Full Name
glutamate receptor, ionotropic, kainate 3provided by MGI
Primary source
MGI:MGI:95816
See related
Ensembl:ENSMUSG00000001985 AllianceGenome:MGI:95816
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GluK3; Glur7; Glur-7; GluR7-3; 9630027E11
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Transcript variants encoding different isoforms have been described for this gene, however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
Expression
Biased expression in frontal lobe adult (RPKM 10.1), whole brain E14.5 (RPKM 9.8) and 8 other tissues See more
Orthologs
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Genomic context

See Grik3 in Genome Data Viewer
Location:
4 D2.2; 4 58.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (125384025..125607966)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (125490259..125714173)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40247 Neighboring gene predicted gene, 32756 Neighboring gene microRNA 692-2 Neighboring gene ferritin light polypeptide 2, pseudogene Neighboring gene predicted gene, 32807 Neighboring gene predicted gene, 54257 Neighboring gene predicted gene, 40249 Neighboring gene RIKEN cDNA 2610028E06 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables kainate selective glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kainate selective glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IEP
Inferred from Expression Pattern
more info
PubMed 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of kainate selective glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate receptor ionotropic, kainate 3
Names
glutamate receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081097.3NP_001074566.1  glutamate receptor ionotropic, kainate 3 precursor

    See identical proteins and their annotated locations for NP_001074566.1

    Status: REVIEWED

    Source sequence(s)
    AL607090, AL627328
    Consensus CDS
    CCDS38878.1
    UniProtKB/Swiss-Prot
    B1AS29, Q9JIA8
    UniProtKB/TrEMBL
    A0A6P5PJB0, A0A8C6MWM7
    Related
    ENSMUSP00000030676.8, ENSMUST00000030676.8
    Conserved Domains (2) summary
    cd06393
    Location:34417
    PBP1_iGluR_Kainate_GluR5_7; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR5-7 subunits of Kainate receptor
    cd13723
    Location:433801
    PBP2_iGluR_Kainate_GluR7; GluR7 subtype of kainate receptor, type 2 periplasmic-binding fold superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    125384025..125607966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502772.4XP_006502835.1  glutamate receptor ionotropic, kainate 3 isoform X1

    UniProtKB/TrEMBL
    A0A6P5PP41
    Conserved Domains (2) summary
    cd13723
    Location:433801
    PBP2_iGluR_Kainate_GluR7; GluR7 subtype of kainate receptor, type 2 periplasmic-binding fold superfamily
    cd06382
    Location:37417
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
  2. XM_036163688.1XP_036019581.1  glutamate receptor ionotropic, kainate 3 isoform X3

    Conserved Domains (2) summary
    cd06382
    Location:37417
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:433697
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  3. XM_017319980.3XP_017175469.1  glutamate receptor ionotropic, kainate 3 isoform X2

    Conserved Domains (2) summary
    cd06382
    Location:37417
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:443733
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily