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Grik2 glutamate receptor, ionotropic, kainate 2 (beta 2) [ Mus musculus (house mouse) ]

Gene ID: 14806, updated on 5-Sep-2021

Summary

Official Symbol
Grik2provided by MGI
Official Full Name
glutamate receptor, ionotropic, kainate 2 (beta 2)provided by MGI
Primary source
MGI:MGI:95815
See related
Ensembl:ENSMUSG00000056073
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glu; Glur; GluK2; Glur6; Glur-6; Glurbe; AW124492; Glurbeta2; C130030K03Rik
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in CNS E18 (RPKM 9.9), whole brain E14.5 (RPKM 6.6) and 5 other tissues See more
Orthologs
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Genomic context

See Grik2 in Genome Data Viewer
Location:
10 B3; 10 24.87 cM
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (48969776..49666523, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (49093680..49790161, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (48819269..49508560, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24256 Neighboring gene predicted gene 3473 Neighboring gene RIKEN cDNA A730099G02 gene Neighboring gene crumbs homolog 1 pseudogene Neighboring gene predicted gene, 40642 Neighboring gene predicted gene, 51833

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellularly glutamate-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables ionotropic glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ionotropic glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables kainate selective glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kainate selective glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables kainate selective glutamate receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables kainate selective glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables kainate selective glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ligand-gated ion channel activity involved in regulation of presynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables ligand-gated ion channel activity involved in regulation of presynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential EXP
Inferred from Experiment
more info
PubMed 
enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of cold stimulus involved in thermoception IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within excitatory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inhibitory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within inhibitory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular protein transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of synaptic transmission, glutamatergic IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuronal action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of short-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of short-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in hippocampal mossy fiber to CA3 synapse EXP
Inferred from Experiment
more info
PubMed 
located_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in hippocampal mossy fiber to CA3 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of ionotropic glutamate receptor complex IC
Inferred by Curator
more info
PubMed 
part_of ionotropic glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of kainate selective glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of kainate selective glutamate receptor complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in synapse TAS
Traceable Author Statement
more info
PubMed 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate receptor ionotropic, kainate 2
Names
gluR beta-2
glutamate receptor 6
glutamate receptor beta-2
proteasome (prosome, macropain) subunit, alpha type 6 pseudogene

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111268.3NP_001104738.2  glutamate receptor ionotropic, kainate 2 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC110043, AC113305, AC115891, AC152981, AC153801, AC153953
    Consensus CDS
    CCDS48554.1
    Related
    ENSMUSP00000151921.2, ENSMUST00000218823.2
    Conserved Domains (2) summary
    cd06382
    Location:37414
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:430800
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  2. NM_001358866.2NP_001345795.2  glutamate receptor ionotropic, kainate 2 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC110043, AC113305, AC115891, AC152981, AC153801, AC153953
    Consensus CDS
    CCDS48554.1
    Conserved Domains (2) summary
    cd06382
    Location:37414
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:430800
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  3. NM_010349.4NP_034479.3  glutamate receptor ionotropic, kainate 2 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional exon at the 3' end compared to transcript variant 1, causing a frame-shift and early translation termination. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC110043, AC113305, AC115891, AC152981, AC153801, AC153953
    Consensus CDS
    CCDS23830.1
    Related
    ENSMUSP00000151671.2, ENSMUST00000218441.2
    Conserved Domains (2) summary
    cd06382
    Location:37414
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:430800
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    48969776..49666523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243120.4XP_011241422.1  glutamate receptor ionotropic, kainate 2 isoform X1

    See identical proteins and their annotated locations for XP_011241422.1

    Conserved Domains (2) summary
    cd06382
    Location:37414
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:430835
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  2. XM_011243123.4XP_011241425.1  glutamate receptor ionotropic, kainate 2 isoform X2

    Conserved Domains (2) summary
    cd06382
    Location:37414
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:430835
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  3. XM_011243124.4XP_011241426.1  glutamate receptor ionotropic, kainate 2 isoform X4

    See identical proteins and their annotated locations for XP_011241426.1

    Conserved Domains (2) summary
    cd06382
    Location:37414
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:430835
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  4. XM_011243122.4XP_011241424.1  glutamate receptor ionotropic, kainate 2 isoform X1

    See identical proteins and their annotated locations for XP_011241424.1

    Conserved Domains (2) summary
    cd06382
    Location:37414
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:430835
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  5. XM_011243121.3XP_011241423.1  glutamate receptor ionotropic, kainate 2 isoform X1

    See identical proteins and their annotated locations for XP_011241423.1

    Conserved Domains (2) summary
    cd06382
    Location:37414
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:430835
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  6. XM_036155621.1XP_036011514.1  glutamate receptor ionotropic, kainate 2 isoform X3

    Related
    ENSMUSP00000101124.4, ENSMUST00000105484.10
    Conserved Domains (2) summary
    cd06382
    Location:37414
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:430800
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  7. XM_030244887.2XP_030100747.1  glutamate receptor ionotropic, kainate 2 isoform X1

    Conserved Domains (2) summary
    cd06382
    Location:37414
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:430835
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  8. XM_006512545.5XP_006512608.1  glutamate receptor ionotropic, kainate 2 isoform X5

    UniProtKB/TrEMBL
    A0A1W2P6S5
    Related
    ENSMUSP00000151389.2, ENSMUST00000218598.2
    Conserved Domains (2) summary
    cd06382
    Location:37414
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:430800
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  9. XM_011243125.4XP_011241427.1  glutamate receptor ionotropic, kainate 2 isoform X4

    See identical proteins and their annotated locations for XP_011241427.1

    Conserved Domains (2) summary
    cd06382
    Location:37414
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:430835
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  10. XM_011243127.4XP_011241429.1  glutamate receptor ionotropic, kainate 2 isoform X6

    Conserved Domains (2) summary
    cd06382
    Location:37414
    PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
    cl21456
    Location:430596
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RNA

  1. XR_003948597.2 RNA Sequence

  2. XR_001779464.3 RNA Sequence

  3. XR_004936102.1 RNA Sequence

  4. XR_001779465.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_018799.1: Suppressed sequence

    Description
    NG_018799.1: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.
  2. NR_046212.1: Suppressed sequence

    Description
    NR_046212.1: This RefSeq was removed because it is composed of UTR sequence.
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