Grik2 glutamate receptor, ionotropic, kainate 2 (beta 2) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grik2provided by MGI
Official Full Name: glutamate receptor, ionotropic, kainate 2 (beta 2)provided by MGI
Primary source: MGI:MGI:95815
See related: Ensembl:ENSMUSG00000056073
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Glu; Glur; GluK2; Glur6; Glur-6; Glurbe; AW124492; Glurbeta2; C130030K03Rik
Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in CNS E18 (RPKM 9.9), whole brain E14.5 (RPKM 6.6) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B3; 10 24.87 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (48969776..49666523, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (49093680..49790161, complement)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	10	NC_000076.5 (48819269..49508560, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Connexin 36 Mediates Orofacial Pain Hypersensitivity Through GluK2 and TRPA1.
Title: Connexin 36 Mediates Orofacial Pain Hypersensitivity Through GluK2 and TRPA1.
Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.
Title: Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.
Hippocampal CA3 kainate receptors have been found to contribute to seizure activities.
Title: Sevoflurane activates hippocampal CA3 kainate receptors (Gluk2) to induce hyperactivity during induction and recovery in a mouse model.
loss of FMRP leads to the abnormal function and localization of kainite receptors.
Title: Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice.
The cytoplasmic domain of the GluK2 low-affinity subunit stabilizes kainate receptors at synapses. In contrast, the extracellular domain of the GluK4/5 high-affinity subunit synergistically controls the synaptic specificity of kainate receptors through interaction with C1q-like proteins.
Title: Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor.
GluK2-mediated increase in KCC2 recycling to the surface membrane translates to a hyperpolarization of the reversal potential for GABA (EGABA).
Title: A kainate receptor subunit promotes the recycling of the neuron-specific K<sup>+</sup>-Cl<sup>-</sup> co-transporter KCC2 in hippocampal neurons.
Loss of parkin function in primary cultured neurons causes GluK2 protein to accumulate in the plasma membrane.
Title: Parkin regulates kainate receptors by interacting with the GluK2 subunit.
Interictal and ictal discharges are minimized in mice lacking the GluK2 subunit.
Title: Contribution of aberrant GluK2-containing kainate receptors to chronic seizures in temporal lobe epilepsy.
14-3-3 proteins are an important regulator of GluK2a-containing KARs and may contribute to the slow decay kinetics of native KAR-EPSCs.
Title: Modulation of GluK2a subunit-containing kainate receptors by 14-3-3 proteins.
This study demonistrated that grik2 gene expression in mouse dorsal raphe nucleus
Title: Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW124492 (e-PCR)
- UniSTS:180037

Grik2 (e-PCR), detects polymorphism
- UniSTS:143259

Homology

Homologs of the Grik2 gene: The Grik2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 340 organisms have orthologs with human gene Grik2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables extracellularly glutamate-gated ion channel activity	ISO Inferred from Sequence Orthology more info
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ion channel activity	IEA Inferred from Electronic Annotation more info
enables ionotropic glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ionotropic glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kainate selective glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables kainate selective glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables kainate selective glutamate receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables kainate selective glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables kainate selective glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated ion channel activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ligand-gated ion channel activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated ion channel activity involved in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin conjugating enzyme binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in detection of cold stimulus involved in thermoception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within excitatory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inhibitory postsynaptic potential	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inhibitory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular protein transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ion transport	IEA Inferred from Electronic Annotation more info
involved_in ion transport	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of synaptic transmission, glutamatergic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of short-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of short-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in hippocampal mossy fiber to CA3 synapse	EXP Inferred from Experiment more info	PubMed
located_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in integral component of membrane	IEA Inferred from Electronic Annotation more info
located_in integral component of plasma membrane	ISO Inferred from Sequence Orthology more info
part_of ionotropic glutamate receptor complex	IC Inferred by Curator more info	PubMed
part_of ionotropic glutamate receptor complex	ISO Inferred from Sequence Orthology more info
part_of kainate selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of kainate selective glutamate receptor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	TAS Traceable Author Statement more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamate receptor ionotropic, kainate 2

Names: gluR beta-2; glutamate receptor 6; glutamate receptor beta-2; proteasome (prosome, macropain) subunit, alpha type 6 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111268.3 → NP_001104738.2 glutamate receptor ionotropic, kainate 2 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AC110043, AC113305, AC115891, AC152981, AC153801, AC153953

Consensus CDS

CCDS48554.1

Related

ENSMUSP00000151921.2, ENSMUST00000218823.2

Conserved Domains (2) summary

cd06382
Location:37 → 414

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:430 → 800

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
NM_001358866.2 → NP_001345795.2 glutamate receptor ionotropic, kainate 2 isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AC110043, AC113305, AC115891, AC152981, AC153801, AC153953

Consensus CDS

CCDS48554.1

Conserved Domains (2) summary

cd06382
Location:37 → 414

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:430 → 800

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
NM_010349.4 → NP_034479.3 glutamate receptor ionotropic, kainate 2 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an additional exon at the 3' end compared to transcript variant 1, causing a frame-shift and early translation termination. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC110043, AC113305, AC115891, AC152981, AC153801, AC153953

Consensus CDS

CCDS23830.1

Related

ENSMUSP00000151671.2, ENSMUST00000218441.2

Conserved Domains (2) summary

cd06382
Location:37 → 414

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:430 → 800

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

48969776..49666523 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243120.4 → XP_011241422.1 glutamate receptor ionotropic, kainate 2 isoform X1

See identical proteins and their annotated locations for XP_011241422.1

Conserved Domains (2) summary

cd06382
Location:37 → 414

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:430 → 835

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_011243123.4 → XP_011241425.1 glutamate receptor ionotropic, kainate 2 isoform X2

Conserved Domains (2) summary

cd06382
Location:37 → 414

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:430 → 835

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_011243124.4 → XP_011241426.1 glutamate receptor ionotropic, kainate 2 isoform X4

See identical proteins and their annotated locations for XP_011241426.1

Conserved Domains (2) summary

cd06382
Location:37 → 414

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:430 → 835

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_011243122.4 → XP_011241424.1 glutamate receptor ionotropic, kainate 2 isoform X1

See identical proteins and their annotated locations for XP_011241424.1

Conserved Domains (2) summary

cd06382
Location:37 → 414

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:430 → 835

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_011243121.3 → XP_011241423.1 glutamate receptor ionotropic, kainate 2 isoform X1

See identical proteins and their annotated locations for XP_011241423.1

Conserved Domains (2) summary

cd06382
Location:37 → 414

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:430 → 835

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_036155621.1 → XP_036011514.1 glutamate receptor ionotropic, kainate 2 isoform X3

Related

ENSMUSP00000101124.4, ENSMUST00000105484.10

Conserved Domains (2) summary

cd06382
Location:37 → 414

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:430 → 800

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_030244887.2 → XP_030100747.1 glutamate receptor ionotropic, kainate 2 isoform X1

Conserved Domains (2) summary

cd06382
Location:37 → 414

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:430 → 835

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_006512545.5 → XP_006512608.1 glutamate receptor ionotropic, kainate 2 isoform X5

UniProtKB/TrEMBL

A0A1W2P6S5

Related

ENSMUSP00000151389.2, ENSMUST00000218598.2

Conserved Domains (2) summary

cd06382
Location:37 → 414

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:430 → 800

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_011243125.4 → XP_011241427.1 glutamate receptor ionotropic, kainate 2 isoform X4

See identical proteins and their annotated locations for XP_011241427.1

Conserved Domains (2) summary

cd06382
Location:37 → 414

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:430 → 835

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_011243127.4 → XP_011241429.1 glutamate receptor ionotropic, kainate 2 isoform X6

Conserved Domains (2) summary

cd06382
Location:37 → 414

PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

cl21456
Location:430 → 596

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RNA

XR_003948597.2 RNA Sequence
XR_001779464.3 RNA Sequence
XR_004936102.1 RNA Sequence
XR_001779465.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NG_018799.1: Suppressed sequence

Description

NG_018799.1: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.
NR_046212.1: Suppressed sequence

Description

NR_046212.1: This RefSeq was removed because it is composed of UTR sequence.