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Grik1 glutamate receptor, ionotropic, kainate 1 [ Mus musculus (house mouse) ]

Gene ID: 14805, updated on 11-Sep-2018

Summary

Official Symbol
Grik1provided by MGI
Official Full Name
glutamate receptor, ionotropic, kainate 1provided by MGI
Primary source
MGI:MGI:95814
See related
Ensembl:ENSMUSG00000022935 Vega:OTTMUSG00000060488
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GluK1; GluK5; Glur5; Glur-5; D16Ium24; D16Ium24e; Glurbeta1; A830007B11Rik
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in CNS E18 (RPKM 5.8), whole brain E14.5 (RPKM 2.9) and 6 other tissues See more
Orthologs

Genomic context

See Grik1 in Genome Data Viewer
Location:
16 C3.3; 16 50.23 cM
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (87895897..88290601, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (87896142..88290503, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32925 Neighboring gene RIKEN cDNA 2810407A14 gene Neighboring gene RIKEN cDNA 4930590A17 gene Neighboring gene predicted gene, 33207 Neighboring gene predicted gene, 46553 Neighboring gene predicted gene, 41486 Neighboring gene predicted gene, 33255 Neighboring gene 40S ribosomal protein S21 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC25101

Gene Ontology Provided by MGI

Function Evidence Code Pubs
drug binding ISO
Inferred from Sequence Orthology
more info
 
extracellularly glutamate-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
glutamate binding ISO
Inferred from Sequence Orthology
more info
 
glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
kainate selective glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kainate selective glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
kainate selective glutamate receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
kainate selective glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
kainate selective glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
voltage-gated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adult behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
excitatory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
inhibitory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
inhibitory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
negative regulation of synaptic transmission, glutamatergic IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gamma-aminobutyric acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term neuronal synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of short-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
regulation of short-term neuronal synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic transmission, glutamatergic IGI
Inferred from Genetic Interaction
more info
PubMed 
synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
ionotropic glutamate receptor complex IC
Inferred by Curator
more info
PubMed 
ionotropic glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
kainate selective glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kainate selective glutamate receptor complex IPI
Inferred from Physical Interaction
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate receptor ionotropic, kainate 1
Names
glutamate receptor subunit 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346964.1NP_001333893.1  glutamate receptor ionotropic, kainate 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' exon structure, resulting in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform c, which has a shorter and distinct C-terminus, compared to isoform a. RNA editing (CAG->CGG) changes Gln621Arg.
    Source sequence(s)
    AC093479, AC118681, AK044420, CT030723
    Consensus CDS
    CCDS84256.1
  2. NM_010348.3NP_034478.1  glutamate receptor ionotropic, kainate 1 isoform b precursor

    See identical proteins and their annotated locations for NP_034478.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an in-frame coding exon at the 3' end compared to transcript variant 1, resulting in a shorter isoform (b) lacking a 29 aa segment compared to isoform a. RNA editing (CAG->CGG) changes Gln621Arg.
    Source sequence(s)
    AK046122, AK133667
    Consensus CDS
    CCDS84254.1
    UniProtKB/TrEMBL
    Q3UZT1, Q8BQZ0
    Related
    ENSMUSP00000023652.9, OTTMUSP00000076980, ENSMUST00000023652.15, OTTMUST00000147977
    Conserved Domains (4) summary
    pfam00060
    Location:562831
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:53396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35415
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:431800
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  3. NM_146072.4NP_666184.2  glutamate receptor ionotropic, kainate 1 isoform a precursor

    See identical proteins and their annotated locations for NP_666184.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). RNA editing (CAG->CGG) changes Gln621Arg.
    Source sequence(s)
    AK043542, AK046122, AK133667
    Consensus CDS
    CCDS84255.1
    UniProtKB/TrEMBL
    Q3UZT1, Q8BQZ0, Q8BRT2
    Related
    ENSMUSP00000072107.6, OTTMUSP00000076981, ENSMUST00000072256.12, OTTMUST00000147978
    Conserved Domains (4) summary
    pfam00060
    Location:562831
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:53396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35415
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:431800
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    87895897..88290601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522919.3XP_006522982.1  glutamate receptor ionotropic, kainate 1 isoform X6

    Conserved Domains (4) summary
    pfam00060
    Location:435704
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:38254
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:40288
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:304673
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  2. XM_006522918.3XP_006522981.1  glutamate receptor ionotropic, kainate 1 isoform X5

    Conserved Domains (4) summary
    pfam00060
    Location:577787
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:53396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35430
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:446790
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  3. XM_006522914.3XP_006522977.1  glutamate receptor ionotropic, kainate 1 isoform X1

    Related
    ENSMUSP00000153786.1, ENSMUST00000227986.1
    Conserved Domains (4) summary
    pfam00060
    Location:577846
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:53396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35430
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:446815
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  4. XM_017316880.1XP_017172369.1  glutamate receptor ionotropic, kainate 1 isoform X7

  5. XM_006522915.3XP_006522978.1  glutamate receptor ionotropic, kainate 1 isoform X2

    Related
    ENSMUSP00000154130.1, ENSMUST00000228188.1
    Conserved Domains (4) summary
    pfam00060
    Location:577846
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:53396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35430
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:446815
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  6. XM_006522916.3XP_006522979.1  glutamate receptor ionotropic, kainate 1 isoform X3

    Conserved Domains (4) summary
    pfam00060
    Location:577846
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:53396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35430
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:446815
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  7. XM_006522917.3XP_006522980.1  glutamate receptor ionotropic, kainate 1 isoform X4

    Related
    ENSMUSP00000147948.1, OTTMUSP00000076982, ENSMUST00000211444.1, OTTMUST00000147979
    Conserved Domains (4) summary
    pfam00060
    Location:562831
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:53396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35415
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:431800
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  8. XM_006522920.3XP_006522983.1  glutamate receptor ionotropic, kainate 1 isoform X8

    Conserved Domains (3) summary
    pfam01094
    Location:53396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35430
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:446600
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  9. XM_006522921.3XP_006522984.1  glutamate receptor ionotropic, kainate 1 isoform X9

    See identical proteins and their annotated locations for XP_006522984.1

    UniProtKB/TrEMBL
    Q8C825
    Conserved Domains (3) summary
    pfam01094
    Location:53396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35415
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:431585
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RNA

  1. XR_384929.3 RNA Sequence

  2. XR_384930.3 RNA Sequence

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