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TICAM1 toll like receptor adaptor molecule 1 [ Homo sapiens (human) ]

Gene ID: 148022, updated on 8-Jul-2021

Summary

Official Symbol
TICAM1provided by HGNC
Official Full Name
toll like receptor adaptor molecule 1provided by HGNC
Primary source
HGNC:HGNC:18348
See related
Ensembl:ENSG00000127666 MIM:607601
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRIF; IIAE6; MyD88-3; PRVTIRB; TICAM-1
Summary
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Ubiquitous expression in esophagus (RPKM 10.4), duodenum (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

See TICAM1 in Genome Data Viewer
Location:
19p13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (4815932..4831712, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4815944..4831724, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene MIR7-3 host gene Neighboring gene microRNA 7-3 Neighboring gene fem-1 homolog A Neighboring gene perilipin 3 Neighboring gene CRISPRi-validated cis-regulatory element chr19.1096 Neighboring gene arrestin domain containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
GeneReviews: Not available
Herpes simplex encephalitis, susceptibility to, 4
MedGen: C3553869 OMIM: 614850 GeneReviews: Not available
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Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC35334

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in TRIF-dependent toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in TRIF-dependent toll-like receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in TRIF-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to oxidised low-density lipoprotein particle stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in lipopolysaccharide-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in macrophage activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of chemokine production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokine production involved in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of myeloid dendritic cell cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of myeloid dendritic cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of natural killer cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in response to exogenous dsRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to exogenous dsRNA ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of ripoptosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
TIR domain-containing adapter molecule 1
Names
TIR domain containing adaptor inducing interferon-beta
TIR domain-containing adapter protein inducing IFN-beta
proline-rich, vinculin and TIR domain-containing protein B
putative NF-kappa-B-activating protein 502H
toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031998.1 RefSeqGene

    Range
    5001..20819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_358

mRNA and Protein(s)

  1. NM_001385678.1NP_001372607.1  TIR domain-containing adapter molecule 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC027319
    Conserved Domains (3) summary
    pfam12721
    Location:642683
    RHIM; RIP homotypic interaction motif
    pfam17798
    Location:3134
    TRIF-NTD; TRIF N-terminal domain
    cl23749
    Location:385513
    TIR_2; TIR domain
  2. NM_001385679.1NP_001372608.1  TIR domain-containing adapter molecule 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC027319
    Conserved Domains (3) summary
    pfam12721
    Location:611652
    RHIM; RIP homotypic interaction motif
    pfam17798
    Location:1103
    TRIF-NTD; TRIF N-terminal domain
    cl23749
    Location:354482
    TIR_2; TIR domain
  3. NM_001385680.1NP_001372609.1  TIR domain-containing adapter molecule 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC027319
    Conserved Domains (2) summary
    pfam12721
    Location:446483
    RHIM; RIP homotypic interaction motif
    cl23749
    Location:185313
    TIR_2; TIR domain
  4. NM_182919.4NP_891549.1  TIR domain-containing adapter molecule 1 isoform 1

    See identical proteins and their annotated locations for NP_891549.1

    Status: REVIEWED

    Source sequence(s)
    AB086380, BC035331, BX349282, DR000002
    Consensus CDS
    CCDS12136.1
    UniProtKB/Swiss-Prot
    Q8IUC6
    Related
    ENSP00000248244.4, ENST00000248244.6
    Conserved Domains (2) summary
    pfam12721
    Location:654696
    RHIM; RIP homotypic interaction motif
    cl23749
    Location:399527
    TIR_2; TIR domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    4815932..4831712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014261.1: Suppressed sequence

    Description
    NM_014261.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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