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Gria4 glutamate receptor, ionotropic, AMPA4 (alpha 4) [ Mus musculus (house mouse) ]

Gene ID: 14802, updated on 29-Oct-2019

Summary

Official Symbol
Gria4provided by MGI
Official Full Name
glutamate receptor, ionotropic, AMPA4 (alpha 4)provided by MGI
Primary source
MGI:MGI:95811
See related
Ensembl:ENSMUSG00000025892
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GluA4; Glur4; spkw1; GluR-D; Glur-4; Gluralpha4
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]
Expression
Biased expression in cerebellum adult (RPKM 34.2), frontal lobe adult (RPKM 17.3) and 6 other tissues See more
Orthologs

Genomic context

See Gria4 in Genome Data Viewer
Location:
9 A1; 9 2.46 cM
Exon count:
21
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (4417893..4796234, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (4417893..4796234, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB (POZ) domain containing 3 Neighboring gene Myb/SANT-like DNA-binding domain containing 4 with coiled-coils Neighboring gene predicted gene, 46101 Neighboring gene predicted gene, 46100 Neighboring gene transcription factor Dp 1 pseudogene Neighboring gene predicted gene, 24896

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
AMPA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMPA glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
kainate selective glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate receptor 4
Names
AMPA-selective glutamate receptor 4
glutamate receptor channel alpha 4
glutamate receptor ionotropic, AMPA 4
spike wave 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113180.1NP_001106651.1  glutamate receptor 4 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate internal coding exon compared to transcript variant 1, and encodes an isoform (2, also known as flop isoform) that is the same length, but with a few amino acid differences compared to isoform 1. RNA editing (AGA->GGA) changes Arg765Gly.
    Source sequence(s)
    AB022913, AK032103, AW488834, BC060697
    Consensus CDS
    CCDS52715.1
    UniProtKB/Swiss-Prot
    Q9Z2W8
    UniProtKB/TrEMBL
    Q8C069
    Related
    ENSMUSP00000027020.6, ENSMUST00000027020.12
    Conserved Domains (4) summary
    cd06388
    Location:28398
    PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
    cd13727
    Location:414795
    PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:546825
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:39380
    ANF_receptor; Receptor family ligand binding region
  2. NM_001113181.1NP_001106652.1  glutamate receptor 4 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is missing several coding exons at the 3' end, and contains a novel 3' terminal exon compared to transcript variant 1. This results in a shorter isoform (3) with a different C-terminus compared to isoform 1.
    Source sequence(s)
    AK032103, BC060697, CA320207
    Consensus CDS
    CCDS52716.1
    UniProtKB/Swiss-Prot
    Q9Z2W8
    UniProtKB/TrEMBL
    E9PX01, Q8C069
    Related
    ENSMUSP00000129316.1, ENSMUST00000163309.1
    Conserved Domains (1) summary
    cd06388
    Location:28398
    PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
  3. NM_019691.4NP_062665.3  glutamate receptor 4 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1 (also known as flip isoform). RNA editing (AGA->GGA) changes Arg765Gly.
    Source sequence(s)
    AB022913, AK032103, AW488834, BC060697
    Consensus CDS
    CCDS22797.1
    UniProtKB/Swiss-Prot
    Q9Z2W8
    UniProtKB/TrEMBL
    Q8C069
    Related
    ENSMUSP00000066980.7, ENSMUST00000063508.14
    Conserved Domains (4) summary
    cd06388
    Location:28398
    PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
    cd13727
    Location:414795
    PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:546825
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:39380
    ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p6 C57BL/6J

    Range
    4417893..4796234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509844.3XP_006509907.1  glutamate receptor 4 isoform X3

    Conserved Domains (4) summary
    cd06388
    Location:28398
    PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
    cd13727
    Location:414795
    PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:546825
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:39380
    ANF_receptor; Receptor family ligand binding region
  2. XM_006509841.3XP_006509904.1  glutamate receptor 4 isoform X2

    Conserved Domains (4) summary
    cd06388
    Location:28398
    PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
    cd13727
    Location:414795
    PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:546825
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:39380
    ANF_receptor; Receptor family ligand binding region
  3. XM_006509843.3XP_006509906.1  glutamate receptor 4 isoform X4

    Conserved Domains (4) summary
    cd06388
    Location:28398
    PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
    cd13727
    Location:414795
    PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:546825
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:39380
    ANF_receptor; Receptor family ligand binding region
  4. XM_006509842.3XP_006509905.1  glutamate receptor 4 isoform X1

    Conserved Domains (4) summary
    cd06388
    Location:28398
    PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
    cd13727
    Location:414795
    PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:546825
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:39380
    ANF_receptor; Receptor family ligand binding region
  5. XM_011242355.3XP_011240657.1  glutamate receptor 4 isoform X6

    See identical proteins and their annotated locations for XP_011240657.1

    Conserved Domains (4) summary
    cd06388
    Location:28398
    PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
    pfam00060
    Location:546766
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:39380
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:414765
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  6. XM_006509845.2XP_006509908.1  glutamate receptor 4 isoform X5

    Conserved Domains (4) summary
    cd06388
    Location:28398
    PBP1_iGluR_AMPA_GluR4; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR4 subunit of the AMPA receptor
    cd13727
    Location:414795
    PBP2_iGluR_AMPA_GluR4; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR4 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam00060
    Location:546805
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:39380
    ANF_receptor; Receptor family ligand binding region

RNA

  1. XR_379085.2 RNA Sequence

  2. XR_001778798.2 RNA Sequence

  3. XR_001778797.2 RNA Sequence

  4. XR_001778800.2 RNA Sequence

  5. XR_379084.4 RNA Sequence

  6. XR_001778799.2 RNA Sequence

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