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ADRA1A adrenoceptor alpha 1A [ Homo sapiens (human) ]

Gene ID: 148, updated on 24-Nov-2020

Summary

Official Symbol
ADRA1Aprovided by HGNC
Official Full Name
adrenoceptor alpha 1Aprovided by HGNC
Primary source
HGNC:HGNC:277
See related
Ensembl:ENSG00000120907 MIM:104221
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADRA1C; ADRA1L1; ALPHA1AAR
Summary
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
Expression
Biased expression in fat (RPKM 3.7), liver (RPKM 3.6) and 6 other tissues See more
Orthologs

Genomic context

See ADRA1A in Genome Data Viewer
Location:
8p21.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (26738113..26870994, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (26605667..26727003, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene PNMA family member 2 Neighboring gene dihydropyrimidinase like 2 Neighboring gene proteasome activator subunit 2 pseudogene 5 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 9 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 4 Neighboring gene uncharacterized LOC105379339 Neighboring gene protein phosphatase 4 regulatory subunit 3B pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha1-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha1-adrenergic receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
alpha1-adrenergic receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
alpha1-adrenergic receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of phospholipase C activity ISS
Inferred from Sequence or Structural Similarity
more info
 
adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adult heart development IEA
Inferred from Electronic Annotation
more info
 
aging ISS
Inferred from Sequence or Structural Similarity
more info
 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
calcium ion transport into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
micturition IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of autophagy IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
neuron-glial cell signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pilomotor reflex IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cardiac muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cardiac muscle hypertrophy IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of heart rate by epinephrine-norepinephrine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase C signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic transmission, GABAergic ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of the force of heart contraction by epinephrine-norepinephrine IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasoconstriction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of vasoconstriction ISS
Inferred from Sequence or Structural Similarity
more info
 
response to drug ISS
Inferred from Sequence or Structural Similarity
more info
 
response to hormone ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
smooth muscle contraction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
T-tubule IEA
Inferred from Electronic Annotation
more info
 
Z disc IEA
Inferred from Electronic Annotation
more info
 
caveola IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
alpha-1A adrenergic receptor
Names
G protein coupled receptor
alpha-1A adrenoceptor
alpha-1A adrenoreceptor
alpha-1C adrenergic receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029395.1 RefSeqGene

    Range
    4751..122256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000680.4NP_000671.2  alpha-1A adrenergic receptor isoform 1

    See identical proteins and their annotated locations for NP_000671.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is alternatively spliced in the 3' end, compared to variant 3. It encodes isoform 1, which has a longer and distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AA383170, AC022839, AC091675, AK289548, AK311558, BF475837, D25235, HY277084
    Consensus CDS
    CCDS6054.1
    UniProtKB/Swiss-Prot
    P35348
    Related
    ENSP00000369947.3, ENST00000380573.4
    Conserved Domains (2) summary
    pfam00001
    Location:43326
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37341
    7tm_4; Olfactory receptor
  2. NM_001322502.1NP_001309431.1  alpha-1A adrenergic receptor isoform 5

    Status: REVIEWED

    Source sequence(s)
    AA568306, AC015564, AC022839, AK289548, AK311558, AY491778, BX101935
    UniProtKB/Swiss-Prot
    P35348
    Conserved Domains (2) summary
    pfam00001
    Location:43300
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37224
    7tm_4; Olfactory receptor
  3. NM_001322503.1NP_001309432.1  alpha-1A adrenergic receptor isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC015564, AC022839, AK289548, AK311558, D32202
    UniProtKB/Swiss-Prot
    P35348
    Conserved Domains (3) summary
    pfam00001
    Location:43303
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam13900
    Location:300339
    GVQW; Putative domain of unknown function
    cl21561
    Location:37224
    7tm_4; Olfactory receptor
  4. NM_001322504.1NP_001309433.1  alpha-1A adrenergic receptor isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022839, AC091675, AK289548, AK311558, AY491781
    Consensus CDS
    CCDS83269.1
    UniProtKB/Swiss-Prot
    P35348
    Related
    ENSP00000369946.3, ENST00000380572.3
    Conserved Domains (2) summary
    pfam00001
    Location:43295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37224
    7tm_4; Olfactory receptor
  5. NM_033302.3NP_150645.2  alpha-1A adrenergic receptor isoform 3

    See identical proteins and their annotated locations for NP_150645.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform 3.
    Source sequence(s)
    AA568306, AC015564, AC022839, AC091675, AK289548, AK311558, BX101935, D32201
    Consensus CDS
    CCDS6052.1
    UniProtKB/Swiss-Prot
    P35348
    Related
    ENSP00000369956.3, ENST00000380582.7
    Conserved Domains (2) summary
    pfam00001
    Location:43326
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37341
    7tm_4; Olfactory receptor
  6. NM_033303.4NP_150646.3  alpha-1A adrenergic receptor isoform 2

    See identical proteins and their annotated locations for NP_150646.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate 3' terminal exon, compared to variant 3. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    AC015564, AC022839, AC091675, AK289548, AK311558, D32202
    Consensus CDS
    CCDS34869.1
    UniProtKB/Swiss-Prot
    P35348
    UniProtKB/TrEMBL
    B0ZBD3
    Related
    ENSP00000369960.1, ENST00000380586.5
    Conserved Domains (2) summary
    pfam00001
    Location:43326
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37341
    7tm_4; Olfactory receptor
  7. NM_033304.3NP_150647.2  alpha-1A adrenergic receptor isoform 4

    See identical proteins and their annotated locations for NP_150647.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) includes an alternate 3' terminal exon, compared to variant 3. It encodes isoform 4, which has a longer and distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    AC022839, AC091675, AF013261, AK289548, AK311558, D32201
    Consensus CDS
    CCDS6053.1
    UniProtKB/Swiss-Prot
    P35348
    Related
    ENSP00000346557.4, ENST00000354550.4
    Conserved Domains (2) summary
    pfam00001
    Location:43326
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37341
    7tm_4; Olfactory receptor

RNA

  1. NR_136343.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC015564, AC022839, AK289548, AK311558, AY491775, D32202

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    26738113..26870994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013094.1XP_016868583.1  alpha-1A adrenergic receptor isoform X1

    UniProtKB/TrEMBL
    B0ZBD3
    Conserved Domains (2) summary
    pfam00001
    Location:43326
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37341
    7tm_4; Olfactory receptor
  2. XM_017013095.1XP_016868584.1  alpha-1A adrenergic receptor isoform X1

    UniProtKB/TrEMBL
    B0ZBD3
    Conserved Domains (2) summary
    pfam00001
    Location:43326
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37341
    7tm_4; Olfactory receptor
  3. XM_006716292.3XP_006716355.1  alpha-1A adrenergic receptor isoform X1

    See identical proteins and their annotated locations for XP_006716355.1

    UniProtKB/TrEMBL
    B0ZBD3
    Conserved Domains (2) summary
    pfam00001
    Location:43326
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37341
    7tm_4; Olfactory receptor
  4. XM_006716293.4XP_006716356.1  alpha-1A adrenergic receptor isoform X2

    See identical proteins and their annotated locations for XP_006716356.1

    UniProtKB/Swiss-Prot
    P35348
    Conserved Domains (2) summary
    pfam00001
    Location:43326
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37341
    7tm_4; Olfactory receptor
  5. XM_017013096.1XP_016868585.1  alpha-1A adrenergic receptor isoform X4

  6. XM_011544412.3XP_011542714.1  alpha-1A adrenergic receptor isoform X5

    Conserved Domains (2) summary
    pfam00001
    Location:43295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37224
    7tm_4; Olfactory receptor
  7. XM_011544411.2XP_011542713.1  alpha-1A adrenergic receptor isoform X3

    See identical proteins and their annotated locations for XP_011542713.1

    UniProtKB/Swiss-Prot
    P35348
    Related
    ENSP00000430414.1, ENST00000521711.5
    Conserved Domains (2) summary
    pfam00001
    Location:43298
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:37224
    7tm_4; Olfactory receptor

RNA

  1. XR_001745477.1 RNA Sequence

  2. XR_001745476.1 RNA Sequence

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