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DPY19L3 dpy-19 like C-mannosyltransferase 3 [ Homo sapiens (human) ]

Gene ID: 147991, updated on 4-Jul-2021

Summary

Official Symbol
DPY19L3provided by HGNC
Official Full Name
dpy-19 like C-mannosyltransferase 3provided by HGNC
Primary source
HGNC:HGNC:27120
See related
Ensembl:ENSG00000178904 MIM:613894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 5.7), prostate (RPKM 5.6) and 25 other tissues See more
Orthologs
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Genomic context

See DPY19L3 in Genome Data Viewer
Location:
19q13.11
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (32405765..32485890)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (32896676..32976796)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 507 Neighboring gene DPY19L3 divergent transcript Neighboring gene programmed cell death 5 Neighboring gene ankyrin repeat domain 27 Neighboring gene small nucleolar RNA, H/ACA box 68B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of bipolar disorder in European American and African American individuals.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr is identified to have a physical interaction with dpy-19-like 3 (DPY19L3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC35440, DKFZp686J17135

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable C-mannosyltransferase DPY19L3
Names
dpy-19 like 3
dpy-19-like 3
dpy-19-like protein 3
protein dpy-19 homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172774.2NP_001166245.1  probable C-mannosyltransferase DPY19L3

    See identical proteins and their annotated locations for NP_001166245.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK126757, AK129497, AL833713, DA852420
    Consensus CDS
    CCDS12422.1
    UniProtKB/Swiss-Prot
    Q6ZPD9
    Related
    ENSP00000376081.2, ENST00000392250.7
    Conserved Domains (1) summary
    pfam10034
    Location:56712
    Dpy19; Q-cell neuroblast polarisation
  2. NM_207325.3NP_997208.2  probable C-mannosyltransferase DPY19L3

    See identical proteins and their annotated locations for NP_997208.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK126757, AL833713, BC131725, DR005952
    Consensus CDS
    CCDS12422.1
    UniProtKB/Swiss-Prot
    Q6ZPD9
    Related
    ENSP00000344937.4, ENST00000342179.9
    Conserved Domains (1) summary
    pfam10034
    Location:56712
    Dpy19; Q-cell neuroblast polarisation

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    32405765..32485890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026367.2XP_016881856.1  probable C-mannosyltransferase DPY19L3 isoform X4

  2. XM_017026366.1XP_016881855.1  probable C-mannosyltransferase DPY19L3 isoform X1

    Conserved Domains (1) summary
    pfam10034
    Location:56677
    Dpy19; Q-cell neuroblast polarisation
  3. XM_011526526.2XP_011524828.1  probable C-mannosyltransferase DPY19L3 isoform X2

    See identical proteins and their annotated locations for XP_011524828.1

    UniProtKB/Swiss-Prot
    Q6ZPD9
    Conserved Domains (1) summary
    pfam10034
    Location:56712
    Dpy19; Q-cell neuroblast polarisation
  4. XM_006723045.1XP_006723108.1  probable C-mannosyltransferase DPY19L3 isoform X3

    Conserved Domains (1) summary
    pfam10034
    Location:1515
    Dpy19; Q-cell neuroblast polarization

RNA

  1. XR_001753614.2 RNA Sequence

  2. XR_935751.1 RNA Sequence

  3. XR_001753613.1 RNA Sequence

  4. XR_935753.2 RNA Sequence

  5. XR_001753612.1 RNA Sequence

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