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ZNF582 zinc finger protein 582 [ Homo sapiens (human) ]

Gene ID: 147948, updated on 5-Jan-2022

Summary

Official Symbol
ZNF582provided by HGNC
Official Full Name
zinc finger protein 582provided by HGNC
Primary source
HGNC:HGNC:26421
See related
Ensembl:ENSG00000018869 MIM:615600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a zing finger protein and putative transcription factor that is highly methylated in cervical cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in thyroid (RPKM 2.0), testis (RPKM 2.0) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF582 in Genome Data Viewer
Location:
19q13.43
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (56382751..56393585, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56894120..56904903, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 5A Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 1 pseudogene Neighboring gene Sharpr-MPRA regulatory region 13801 Neighboring gene zinc finger protein 542, pseudogene Neighboring gene SLC25A36 pseudogene 1 Neighboring gene ZNF582 divergent transcript Neighboring gene zinc finger protein 583

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30927

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050571.1 RefSeqGene

    Range
    5052..15835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320371.4NP_001307300.2  zinc finger protein 582 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC006116
    Related
    ENSP00000465619.1, ENST00000586929.6
    Conserved Domains (4) summary
    smart00349
    Location:866
    KRAB; krueppel associated box
    COG5048
    Location:180408
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:341361
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:409434
    zf-H2C2_2; Zinc-finger double domain
  2. NM_144690.3NP_653291.1  zinc finger protein 582 isoform 2

    See identical proteins and their annotated locations for NP_653291.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC006116, AK055489, AW080639, BX104812, DA929494
    Consensus CDS
    CCDS33121.1
    UniProtKB/Swiss-Prot
    Q96NG8
    UniProtKB/TrEMBL
    A0A024R4P7
    Related
    ENSP00000301310.3, ENST00000301310.8
    Conserved Domains (4) summary
    smart00349
    Location:866
    KRAB; krueppel associated box
    COG5048
    Location:180408
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:341361
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:409434
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    56382751..56393585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_430188.3 RNA Sequence

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