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ZNF420 zinc finger protein 420 [ Homo sapiens (human) ]

Gene ID: 147923, updated on 23-Nov-2021

Summary

Official Symbol
ZNF420provided by HGNC
Official Full Name
zinc finger protein 420provided by HGNC
Primary source
HGNC:HGNC:20649
See related
Ensembl:ENSG00000197050 MIM:617216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APAK
Summary
The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in testis (RPKM 3.6), ovary (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF420 in Genome Data Viewer
Location:
19q13.12
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (37007815..37130368)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37569124..37621270)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 829 Neighboring gene ribosomal protein L31 pseudogene 61 Neighboring gene zinc finger protein 568 Neighboring gene uncharacterized LOC105372390 Neighboring gene zinc finger protein 585A Neighboring gene Sharpr-MPRA regulatory region 11816 Neighboring gene zinc finger protein 585B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32191

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 420
Names
ATM and p53-associated KZNF protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051212.1 RefSeqGene

    Range
    75408..127553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001329515.3NP_001316444.1  zinc finger protein 420 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC010632, AC012309
  2. NM_001329516.3NP_001316445.1  zinc finger protein 420 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC010632, AC012309
    Conserved Domains (5) summary
    smart00349
    Location:648
    KRAB; krueppel associated box
    COG5048
    Location:165577
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:561581
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:434458
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001329517.1NP_001316446.1  zinc finger protein 420 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes isoform d, as do variants 5, 6, and 7.
    Source sequence(s)
    AC010632, AC012309
    Conserved Domains (3) summary
    COG5048
    Location:94506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558583
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001329518.1NP_001316447.1  zinc finger protein 420 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) encodes isoform d, as do variants 4, 6, and 7.
    Source sequence(s)
    AC010632, AC012309
    Conserved Domains (3) summary
    COG5048
    Location:94506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558583
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001329519.1NP_001316448.1  zinc finger protein 420 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes isoform d, as do variants 4, 5, and 7.
    Source sequence(s)
    AC010632, AC012309
    Conserved Domains (3) summary
    COG5048
    Location:94506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558583
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001329520.1NP_001316449.1  zinc finger protein 420 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes isoform d, as do variants 4, 5, and 6.
    Source sequence(s)
    AC010632, AC012309
    Conserved Domains (3) summary
    COG5048
    Location:94506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558583
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001329521.3NP_001316450.1  zinc finger protein 420 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC010632, AC012309
    Conserved Domains (3) summary
    COG5048
    Location:94506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:503527
    zf-H2C2_2; Zinc-finger double domain
  8. NM_001329522.3NP_001316451.1  zinc finger protein 420 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC010632, AC012309, AK056753
    Consensus CDS
    CCDS86757.1
    UniProtKB/Swiss-Prot
    Q8TAQ5
    Related
    ENSP00000306102.7, ENST00000304239.11
    Conserved Domains (6) summary
    smart00349
    Location:648
    KRAB; krueppel associated box
    COG5048
    Location:137472
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393413
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:223245
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:434458
    zf-H2C2_2; Zinc-finger double domain
  9. NM_001329524.3NP_001316453.1  zinc finger protein 420 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC010632, AC012309
  10. NM_144689.5NP_653290.2  zinc finger protein 420 isoform b

    See identical proteins and their annotated locations for NP_653290.2

    Status: REVIEWED

    Source sequence(s)
    AC012309, AK315728
    Consensus CDS
    CCDS12498.1
    UniProtKB/Swiss-Prot
    Q8TAQ5
    Related
    ENSP00000338770.2, ENST00000337995.4
    Conserved Domains (4) summary
    COG5048
    Location:165577
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:589609
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
    pfam13465
    Location:629654
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_138039.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC010632

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    37007815..37130368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526510.2XP_011524812.1  zinc finger protein 420 isoform X3

    See identical proteins and their annotated locations for XP_011524812.1

    Conserved Domains (3) summary
    COG5048
    Location:94506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558583
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011526503.2XP_011524805.1  zinc finger protein 420 isoform X1

    See identical proteins and their annotated locations for XP_011524805.1

    UniProtKB/Swiss-Prot
    Q8TAQ5
    Conserved Domains (4) summary
    COG5048
    Location:165577
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:589609
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
    pfam13465
    Location:629654
    zf-H2C2_2; Zinc-finger double domain
  3. XM_024451382.1XP_024307150.1  zinc finger protein 420 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:94506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:503527
    zf-H2C2_2; Zinc-finger double domain
  4. XM_006723038.3XP_006723101.1  zinc finger protein 420 isoform X2

    Conserved Domains (5) summary
    smart00349
    Location:648
    KRAB; krueppel associated box
    COG5048
    Location:165577
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:561581
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:434458
    zf-H2C2_2; Zinc-finger double domain
  5. XM_011526511.2XP_011524813.1  zinc finger protein 420 isoform X5

    Conserved Domains (5) summary
    smart00349
    Location:648
    KRAB; krueppel associated box
    COG5048
    Location:137477
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393413
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:434458
    zf-H2C2_2; Zinc-finger double domain
  6. XM_011526508.2XP_011524810.1  zinc finger protein 420 isoform X3

    See identical proteins and their annotated locations for XP_011524810.1

    Conserved Domains (3) summary
    COG5048
    Location:94506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558583
    zf-H2C2_2; Zinc-finger double domain
  7. XM_011526507.3XP_011524809.1  zinc finger protein 420 isoform X3

    See identical proteins and their annotated locations for XP_011524809.1

    Conserved Domains (3) summary
    COG5048
    Location:94506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558583
    zf-H2C2_2; Zinc-finger double domain
  8. XM_011526504.2XP_011524806.1  zinc finger protein 420 isoform X1

    See identical proteins and their annotated locations for XP_011524806.1

    UniProtKB/Swiss-Prot
    Q8TAQ5
    Conserved Domains (4) summary
    COG5048
    Location:165577
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:589609
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:546
    KRAB; KRAB box
    pfam13465
    Location:629654
    zf-H2C2_2; Zinc-finger double domain
  9. XM_017026338.1XP_016881827.1  zinc finger protein 420 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:94506
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:558583
    zf-H2C2_2; Zinc-finger double domain
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