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IGFL2 IGF like family member 2 [ Homo sapiens (human) ]

Gene ID: 147920, updated on 5-Jan-2022

Summary

Official Symbol
IGFL2provided by HGNC
Official Full Name
IGF like family member 2provided by HGNC
Primary source
HGNC:HGNC:32929
See related
Ensembl:ENSG00000204866 MIM:610545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ645; VPRI645
Summary
IGFL2 belongs to the insulin-like growth factor (IGF; see MIM 147440) family of signaling molecules that play critical roles in cellular energy metabolism and in growth and development, especially prenatal growth (Emtage et al., 2006 [PubMed 16890402]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in skin (RPKM 2.9) and testis (RPKM 1.1) See more
Orthologs
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Genomic context

See IGFL2 in Genome Data Viewer
Location:
19q13.32
Exon count:
26
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (46078513..46215362)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46651039..46664546)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372421 Neighboring gene IGF like family member 4 Neighboring gene solute carrier family 30 member 5 pseudogene Neighboring gene IGF like family member 3 Neighboring gene uncharacterized LOC105376901 Neighboring gene TGFB induced factor homeobox 1 pseudogene 1 Neighboring gene uncharacterized LOC105372424 Neighboring gene Sharpr-MPRA regulatory region 10795 Neighboring gene IGFL2 antisense RNA 1 Neighboring gene IGF like family member 1 pseudogene 1 Neighboring gene uncharacterized LOC93429 Neighboring gene ribosomal protein L12 pseudogene 41 Neighboring gene IGF like family member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • AC007193.6

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
insulin growth factor-like family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002915.3NP_001002915.2  insulin growth factor-like family member 2 isoform a

    See identical proteins and their annotated locations for NP_001002915.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC007785, AW009166, AY672112, BC130490
    Consensus CDS
    CCDS46122.1
    UniProtKB/Swiss-Prot
    Q6UWQ7
    Related
    ENSP00000395219.1, ENST00000434646.6
    Conserved Domains (1) summary
    pfam14653
    Location:41123
    IGFL; Insulin growth factor-like family
  2. NM_001135113.2NP_001128585.1  insulin growth factor-like family member 2 isoform b precursor

    See identical proteins and their annotated locations for NP_001128585.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1, resulting in an isoform (b) that has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC007785, AW009166, AY358692, BC130490
    Consensus CDS
    CCDS46121.1
    UniProtKB/Swiss-Prot
    Q6UWQ7
    Related
    ENSP00000366922.3, ENST00000377693.5
    Conserved Domains (1) summary
    pfam14653
    Location:24112
    IGFL; Insulin growth factor-like family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    46078513..46215362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451381.1XP_024307149.1  insulin growth factor-like family member 2 isoform X1

    Conserved Domains (1) summary
    pfam14653
    Location:41123
    IGFL; Insulin growth factor-like family
  2. XM_011526501.1XP_011524803.1  insulin growth factor-like family member 2 isoform X1

    See identical proteins and their annotated locations for XP_011524803.1

    UniProtKB/Swiss-Prot
    Q6UWQ7
    Conserved Domains (1) summary
    pfam14653
    Location:41123
    IGFL; Insulin growth factor-like family

RNA

  1. XR_935744.2 RNA Sequence

  2. XR_935743.2 RNA Sequence

  3. XR_001753605.1 RNA Sequence

  4. XR_001753604.1 RNA Sequence

  5. XR_002958260.1 RNA Sequence

  6. XR_002958261.1 RNA Sequence

  7. XR_002958257.1 RNA Sequence

  8. XR_002958259.1 RNA Sequence

  9. XR_002958265.1 RNA Sequence

  10. XR_002958267.1 RNA Sequence

  11. XR_002958262.1 RNA Sequence

  12. XR_002958263.1 RNA Sequence

  13. XR_002958266.1 RNA Sequence

  14. XR_002958269.1 RNA Sequence

  15. XR_002958264.1 RNA Sequence

  16. XR_002958270.1 RNA Sequence

  17. XR_002958272.1 RNA Sequence

  18. XR_002958271.1 RNA Sequence

  19. XR_002958258.1 RNA Sequence

  20. XR_002958268.1 RNA Sequence

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