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DACT3 dishevelled binding antagonist of beta catenin 3 [ Homo sapiens (human) ]

Gene ID: 147906, updated on 22-May-2022

Summary

Official Symbol
DACT3provided by HGNC
Official Full Name
dishevelled binding antagonist of beta catenin 3provided by HGNC
Primary source
HGNC:HGNC:30745
See related
Ensembl:ENSG00000197380 MIM:611112; AllianceGenome:HGNC:30745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RRR1; DAPPER3
Summary
Predicted to enable delta-catenin binding activity; protein kinase A binding activity; and protein kinase C binding activity. Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of cell growth. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 11.1), endometrium (RPKM 7.4) and 17 other tissues See more
Orthologs
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Genomic context

See DACT3 in Genome Data Viewer
Location:
19q13.32
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (46647551..46661182, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (49473085..49486718, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47150808..47164439, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene calmodulin 3 Neighboring gene prostaglandin I2 receptor Neighboring gene G protein subunit gamma 8 Neighboring gene DACT3 antisense RNA 1 Neighboring gene protein kinase D2 Neighboring gene RNA, 7SL, cytoplasmic 364, pseudogene Neighboring gene microRNA 320e

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC15476

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables delta-catenin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase C binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dapper homolog 3
Names
antagonist of beta-catenin Dapper homolog 3
arginine-rich region 1 protein
dapper, antagonist of beta-catenin, homolog 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301046.2NP_001287975.1  dapper homolog 3 isoform 2

    See identical proteins and their annotated locations for NP_001287975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC093503, AI769079, BC016161, BE274342, BF515069, BX097198
    Consensus CDS
    CCDS74402.1
    UniProtKB/Swiss-Prot
    Q96B18
    UniProtKB/TrEMBL
    A0A0C4DFP1
    Related
    ENSP00000300875.4, ENST00000300875.4
    Conserved Domains (1) summary
    pfam15268
    Location:22404
    Dapper; Dapper
  2. NM_145056.3NP_659493.2  dapper homolog 3 isoform 1

    See identical proteins and their annotated locations for NP_659493.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC093503
    Consensus CDS
    CCDS12688.2
    UniProtKB/Swiss-Prot
    Q96B18
    Related
    ENSP00000375783.2, ENST00000391916.7
    Conserved Domains (1) summary
    pfam15268
    Location:20629
    Dapper; Dapper

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    46647551..46661182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526499.3XP_011524801.1  dapper homolog 3 isoform X2

    See identical proteins and their annotated locations for XP_011524801.1

    UniProtKB/Swiss-Prot
    Q96B18
    UniProtKB/TrEMBL
    A0A0C4DFP1
    Conserved Domains (1) summary
    pfam15268
    Location:22404
    Dapper; Dapper
  2. XM_017026334.2XP_016881823.1  dapper homolog 3 isoform X1

  3. XM_011526500.3XP_011524802.1  dapper homolog 3 isoform X2

    See identical proteins and their annotated locations for XP_011524802.1

    UniProtKB/Swiss-Prot
    Q96B18
    UniProtKB/TrEMBL
    A0A0C4DFP1
    Conserved Domains (1) summary
    pfam15268
    Location:22404
    Dapper; Dapper

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    49473085..49486718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)