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Grb2 growth factor receptor bound protein 2 [ Mus musculus (house mouse) ]

Gene ID: 14784, updated on 10-Oct-2019

Summary

Official Symbol
Grb2provided by MGI
Official Full Name
growth factor receptor bound protein 2provided by MGI
Primary source
MGI:MGI:95805
See related
Ensembl:ENSMUSG00000059923
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ash; AA408164
Summary
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in CNS E18 (RPKM 40.7), frontal lobe adult (RPKM 37.9) and 28 other tissues See more
Orthologs

Genomic context

See Grb2 in Genome Data Viewer
Location:
11 E2; 11 80.91 cM
Exon count:
7
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115644045..115708597, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (115505444..115569911, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene mitchondrial ribosomal protein S7 Neighboring gene MIF4G domain containing Neighboring gene solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene predicted gene, 42096 Neighboring gene 60S ribosomal protein L21 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
SH3/SH2 adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
insulin receptor substrate binding ISO
Inferred from Sequence Orthology
more info
 
neurotrophin TRKA receptor binding ISO
Inferred from Sequence Orthology
more info
 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
aging ISO
Inferred from Sequence Orthology
more info
 
anatomical structure formation involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in labyrinthine layer morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament polymerization IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
receptor internalization ISO
Inferred from Sequence Orthology
more info
 
regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Grb2-EGFR complex ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
growth factor receptor-bound protein 2
Names
SH2/SH3 adapter GRB2
adapter protein GRB2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313936.1NP_001300865.1  growth factor receptor-bound protein 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK155800, BC052377, BQ174314, BY292622
    Consensus CDS
    CCDS25645.1
    UniProtKB/Swiss-Prot
    Q60631
    UniProtKB/TrEMBL
    Q3U1Q4, Q3U5I5
    Conserved Domains (3) summary
    cd09941
    Location:56150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:156
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
  2. NM_001313937.1NP_001300866.1  growth factor receptor-bound protein 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK155800, BC052377, BQ174314, BY266228
    Consensus CDS
    CCDS25645.1
    UniProtKB/Swiss-Prot
    Q60631
    UniProtKB/TrEMBL
    Q3U1Q4, Q3U5I5
    Related
    ENSMUSP00000102106.1, ENSMUST00000106497.7
    Conserved Domains (3) summary
    cd09941
    Location:56150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:156
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
  3. NM_008163.4NP_032189.1  growth factor receptor-bound protein 2

    See identical proteins and their annotated locations for NP_032189.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AK155800, BC052377, BQ174314
    Consensus CDS
    CCDS25645.1
    UniProtKB/Swiss-Prot
    Q60631
    UniProtKB/TrEMBL
    Q3U1Q4, Q3U5I5
    Related
    ENSMUSP00000021090.7, ENSMUST00000021090.13
    Conserved Domains (3) summary
    cd09941
    Location:56150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:156
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    115644045..115708597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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