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Grb2 growth factor receptor bound protein 2 [ Mus musculus (house mouse) ]

Gene ID: 14784, updated on 1-Jul-2024

Summary

Official Symbol
Grb2provided by MGI
Official Full Name
growth factor receptor bound protein 2provided by MGI
Primary source
MGI:MGI:95805
See related
Ensembl:ENSMUSG00000059923 AllianceGenome:MGI:95805
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ash
Summary
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in CNS E18 (RPKM 40.7), frontal lobe adult (RPKM 37.9) and 28 other tissues See more
Orthologs
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Genomic context

See Grb2 in Genome Data Viewer
Location:
11 E2; 11 80.91 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115534871..115599423, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115644045..115708597, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7096 Neighboring gene mitchondrial ribosomal protein S7 Neighboring gene MIF4G domain containing Neighboring gene solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 Neighboring gene STARR-seq mESC enhancer starr_31166 Neighboring gene STARR-positive B cell enhancer mm9_chr11:115494169-115494470 Neighboring gene STARR-positive B cell enhancer ABC_E8470 Neighboring gene STARR-positive B cell enhancer ABC_E2375 Neighboring gene STARR-positive B cell enhancer ABC_E10730 Neighboring gene STARR-positive B cell enhancer ABC_E7098 Neighboring gene STARR-positive B cell enhancer ABC_E9146 Neighboring gene STARR-positive B cell enhancer ABC_E10731 Neighboring gene STARR-positive B cell enhancer ABC_E3038 Neighboring gene predicted gene, 42096 Neighboring gene predicted gene 11703 Neighboring gene predicted gene, 23699

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (9)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables epidermal growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor adaptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin receptor substrate binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables neurotrophin TRKA receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphotyrosine residue binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase adaptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase adaptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ERBB2-ERBB3 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in Schwann cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within endodermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin-like growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of actin filament polymerization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
part_of Grb2-EGFR complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell cortex IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
growth factor receptor-bound protein 2
Names
SH2/SH3 adapter GRB2
adapter protein GRB2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313936.1NP_001300865.1  growth factor receptor-bound protein 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK155800, BC052377, BQ174314, BY292622
    Consensus CDS
    CCDS25645.1
    UniProtKB/Swiss-Prot
    Q60631, Q61240
    UniProtKB/TrEMBL
    Q3U1Q4, Q3U5I5
    Conserved Domains (3) summary
    cd09941
    Location:56150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:156
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
  2. NM_001313937.1NP_001300866.1  growth factor receptor-bound protein 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
    Source sequence(s)
    AK155800, BC052377, BQ174314, BY266228
    Consensus CDS
    CCDS25645.1
    UniProtKB/Swiss-Prot
    Q60631, Q61240
    UniProtKB/TrEMBL
    Q3U1Q4, Q3U5I5
    Related
    ENSMUSP00000102106.2, ENSMUST00000106497.8
    Conserved Domains (3) summary
    cd09941
    Location:56150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:156
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
  3. NM_008163.4NP_032189.1  growth factor receptor-bound protein 2

    See identical proteins and their annotated locations for NP_032189.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
    Source sequence(s)
    AK155800, BC052377, BQ174314
    Consensus CDS
    CCDS25645.1
    UniProtKB/Swiss-Prot
    Q60631, Q61240
    UniProtKB/TrEMBL
    Q3U1Q4, Q3U5I5
    Related
    ENSMUSP00000021090.8, ENSMUST00000021090.14
    Conserved Domains (3) summary
    cd09941
    Location:56150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:156
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    115534871..115599423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)