Grb2 growth factor receptor bound protein 2 [ Mus musculus (house mouse) ]

Gene ID: 14784, updated on 10-Oct-2019

Summary

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Official Symbol: Grb2provided by MGI
Official Full Name: growth factor receptor bound protein 2provided by MGI
Primary source: MGI:MGI:95805
See related: Ensembl:ENSMUSG00000059923
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ash; AA408164
Summary: The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Three alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]
Expression: Ubiquitous expression in CNS E18 (RPKM 40.7), frontal lobe adult (RPKM 37.9) and 28 other tissues See more
Orthologs: human all

Genomic context

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See Grb2 in Genome Data Viewer

Location:: 11 E2; 11 80.91 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
108	current	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (115644045..115708597, complement)
Build 37.2	previous assembly	MGSCv37 (GCF_000001635.18)	11	NC_000077.5 (115505444..115569911, complement)

Chromosome 11 - NC_000077.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GRB2 inhibitors may have the potential to dampen tissue eosinophilia in various eosinophil-associated diseases.
Title: Murine eosinophil development and allergic lung eosinophilia are largely dependent on the signaling adaptor GRB2.
Study shows that growth factor receptor binding protein 2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner. Extrapolating the results of this study to the in vivo conditions, Grb2 should bind the SLP65 transducer module first, and then Vav should associate.
Title: Grb2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner.
Our findings position Grb2 as a key adaptor that integrates various cytokines response in cycling Hematopoietic Stem and Progenitor Cell .
Title: Grb2 regulates the proliferation of hematopoietic stem and progenitors cells.
Themis1 acts as a positive regulator of TCR signaling during thymocyte development by promoting Vav1 activity and Grb2 stability
Title: Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.
Myogenic differentiation depends on the expression regulation patterns of Grb2 and N-WASP.
Title: Myogenic differentiation depends on the interplay of Grb2 and N-WASP.
Two Dtna interactors, alpha-catulin (phosphorylation independent) and Grb2 (phosphorylation dependent) are localized to neuromuscular junctions in vivo, and are required for proper organization of neurotransmitter receptors on myotubes.
Title: Α-Dystrobrevin-1 recruits Grb2 and α-catulin to organize neurotransmitter receptors at the neuromuscular junction.
Grb2-deficient T cells show defects in T cell development, increased Th1 and Th17 cell differentiation capacities, and impaired proliferation after activation by dendritic cells, which likely reduce the clinical symptoms of EAE.
Title: Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis.
provide evidence that CD28 and the TCR complex regulate NF-kappaB via different signaling modules of GRB-2/VAV1 and LAT/ADAP pathways respectively.
Title: TCR and CD28 activate the transcription factor NF-κB in T-cells via distinct adaptor signaling complexes.
GRB2 physically links cyt-PTPe with Src and enables cyt-PTPe to activate Src downstream of activated integrins in osteoclast-like cells.
Title: Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts.
SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1.
Title: SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation

Pathways from BioSystems

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ARMS-mediated activation, organism-specific biosystem (from REACTOME)
ARMS-mediated activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Acute myeloid leukemia, organism-specific biosystem (from KEGG)
Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
Acute myeloid leukemia, conserved biosystem (from KEGG)
Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Alcoholism, organism-specific biosystem (from KEGG)
Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
Alcoholism, conserved biosystem (from KEGG)
Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystemIntegrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands...
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, organism-specific biosystem (from REACTOME)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
B cell receptor signaling pathway, conserved biosystem (from KEGG)
B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
Breast cancer, organism-specific biosystem (from KEGG)
Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
Breast cancer, conserved biosystem (from KEGG)
Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
CD28 co-stimulation, organism-specific biosystem (from REACTOME)
CD28 co-stimulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CD28 dependent Vav1 pathway, organism-specific biosystem (from REACTOME)
CD28 dependent Vav1 pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
Cargo recognition for clathrin-mediated endocytosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
Cell surface interactions at the vascular wall, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell-Cell communication, organism-specific biosystem (from REACTOME)
Cell-Cell communication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Choline metabolism in cancer, organism-specific biosystem (from KEGG)
Choline metabolism in cancer, organism-specific biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
Choline metabolism in cancer, conserved biosystem (from KEGG)
Choline metabolism in cancer, conserved biosystemAbnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, oncogenic signalling via pathways such as the RAS...
Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
Chronic myeloid leukemia, organism-specific biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
Chronic myeloid leukemia, conserved biosystem (from KEGG)
Chronic myeloid leukemia, conserved biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
Clathrin-mediated endocytosis, organism-specific biosystem (from REACTOME)
Clathrin-mediated endocytosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
Costimulation by the CD28 family, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 interactions, organism-specific biosystem (from REACTOME)
DAP12 interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 signaling, organism-specific biosystem (from REACTOME)
DAP12 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dorso-ventral axis formation, organism-specific biosystem (from KEGG)
Dorso-ventral axis formation, organism-specific biosystem
Dorso-ventral axis formation
Dorso-ventral axis formation, conserved biosystem (from KEGG)
Dorso-ventral axis formation, conserved biosystem
Dorso-ventral axis formation
Downstream signal transduction, organism-specific biosystem (from REACTOME)
Downstream signal transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Downstream signaling events of B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling of activated FGFR1, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling of activated FGFR2, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling of activated FGFR3, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR3, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling of activated FGFR4, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR Transactivation by Gastrin, organism-specific biosystem (from REACTOME)
EGFR Transactivation by Gastrin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR downregulation, organism-specific biosystem (from REACTOME)
EGFR downregulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
EGFR tyrosine kinase inhibitor resistance, organism-specific biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
EGFR tyrosine kinase inhibitor resistance, conserved biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
EPO Receptor Signaling, organism-specific biosystem (from WikiPathways)
EPO Receptor Signaling, organism-specific biosystemThe erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activat...
ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
Endocrine resistance, organism-specific biosystem (from KEGG)
Endocrine resistance, organism-specific biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
Endocrine resistance, conserved biosystem (from KEGG)
Endocrine resistance, conserved biosystemEndocrine therapy is a key treatment strategy to control or eradicate hormone-responsive breast cancer. The most commonly used endocrine therapy agents are selective estrogen receptor modulators (SER...
Endometrial cancer, organism-specific biosystem (from KEGG)
Endometrial cancer, organism-specific biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
Endometrial cancer, conserved biosystem (from KEGG)
Endometrial cancer, conserved biosystemEndometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endom...
ErbB signaling pathway, organism-specific biosystem (from KEGG)
ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
ErbB signaling pathway, conserved biosystem (from KEGG)
ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
Estrogen signaling, organism-specific biosystem (from WikiPathways)
Estrogen signaling, organism-specific biosystemEstrogen receptor refers to a group of receptors which are activated by the hormone 17&amp;#x3b2;-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear h...
Estrogen signaling pathway, organism-specific biosystem (from KEGG)
Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
Estrogen signaling pathway, conserved biosystem (from KEGG)
Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
FCERI mediated Ca+2 mobilization, organism-specific biosystem (from REACTOME)
FCERI mediated Ca+2 mobilization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
FCERI mediated MAPK activation, organism-specific biosystem (from REACTOME)
FCERI mediated MAPK activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
FRS-mediated FGFR1 signaling, organism-specific biosystem (from REACTOME)
FRS-mediated FGFR1 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
FRS-mediated FGFR2 signaling, organism-specific biosystem (from REACTOME)
FRS-mediated FGFR2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
FRS-mediated FGFR3 signaling, organism-specific biosystem (from REACTOME)
FRS-mediated FGFR3 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
FRS-mediated FGFR4 signaling, organism-specific biosystem (from REACTOME)
FRS-mediated FGFR4 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
Fc epsilon RI signaling pathway, organism-specific biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
Fc epsilon receptor (FCERI) signaling, organism-specific biosystem (from REACTOME)
Fc epsilon receptor (FCERI) signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Focal Adhesion, organism-specific biosystem (from WikiPathways)
Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, organism-specific biosystem (from KEGG)
Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, conserved biosystem (from KEGG)
Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
FoxO signaling pathway, organism-specific biosystem (from KEGG)
FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
Frs2-mediated activation, organism-specific biosystem (from REACTOME)
Frs2-mediated activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G beta:gamma signalling through PI3Kgamma, organism-specific biosystem (from REACTOME)
G beta:gamma signalling through PI3Kgamma, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G-protein beta:gamma signalling, organism-specific biosystem (from REACTOME)
G-protein beta:gamma signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GAB1 signalosome, organism-specific biosystem (from REACTOME)
GAB1 signalosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPVI-mediated activation cascade, organism-specific biosystem (from REACTOME)
GPVI-mediated activation cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GRB2 events in EGFR signaling, organism-specific biosystem (from REACTOME)
GRB2 events in EGFR signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GRB2 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
GRB2 events in ERBB2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GRB2:SOS provides linkage to MAPK signaling for Integrins, organism-specific biosystem (from REACTOME)
GRB2:SOS provides linkage to MAPK signaling for Integrins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gap junction, organism-specific biosystem (from KEGG)
Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Gap junction, conserved biosystem (from KEGG)
Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glioma, organism-specific biosystem (from KEGG)
Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
Glioma, conserved biosystem (from KEGG)
Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
GnRH signaling pathway, organism-specific biosystem (from KEGG)
GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
GnRH signaling pathway, conserved biosystem (from KEGG)
GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hepatitis B, organism-specific biosystem (from KEGG)
Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
Hepatitis C, organism-specific biosystem (from KEGG)
Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
Hepatitis C, conserved biosystem (from KEGG)
Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
IGF1R signaling cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IL-2 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-2 Signaling Pathway, organism-specific biosystemIL-2 is a multifunctional cytokine with pleiotropic effects on several cells of the immune system. IL-2 was originally discovered as a T cell growth factor, but it was also found to have actions rela...
IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-5 Signaling Pathway, organism-specific biosystem
IL-5 Signaling Pathway
IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-6 signaling Pathway, organism-specific biosystem
IL-6 signaling Pathway
IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-7 Signaling Pathway, organism-specific biosystem
IL-7 Signaling Pathway
IL-9 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-9 Signaling Pathway, organism-specific biosystem
IL-9 Signaling Pathway
IRS-mediated signalling, organism-specific biosystem (from REACTOME)
IRS-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
IRS-related events triggered by IGF1R, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Insulin Signaling, organism-specific biosystem (from WikiPathways)
Insulin Signaling, organism-specific biosystem
Insulin Signaling
Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
Insulin receptor signalling cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Insulin signaling pathway, organism-specific biosystem (from KEGG)
Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
Insulin signaling pathway, conserved biosystem (from KEGG)
Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
Integrin alphaIIb beta3 signaling, organism-specific biosystem (from REACTOME)
Integrin alphaIIb beta3 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Integrin-mediated Cell Adhesion, organism-specific biosystem (from WikiPathways)
Integrin-mediated Cell Adhesion, organism-specific biosystemIntegrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and ...
Interleukin receptor SHC signaling, organism-specific biosystem (from REACTOME)
Interleukin receptor SHC signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin-2 signaling, organism-specific biosystem (from REACTOME)
Interleukin-2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystem (from REACTOME)
Interleukin-3, 5 and GM-CSF signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
MAPK family signaling cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK1/MAPK3 signaling, organism-specific biosystem (from REACTOME)
MAPK1/MAPK3 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MET activates PI3K/AKT signaling, organism-specific biosystem (from REACTOME)
MET activates PI3K/AKT signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MET activates PTPN11, organism-specific biosystem (from REACTOME)
MET activates PTPN11, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MET activates RAP1 and RAC1, organism-specific biosystem (from REACTOME)
MET activates RAP1 and RAC1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MET activates RAS signaling, organism-specific biosystem (from REACTOME)
MET activates RAS signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MET promotes cell motility, organism-specific biosystem (from REACTOME)
MET promotes cell motility, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MET receptor recycling, organism-specific biosystem (from REACTOME)
MET receptor recycling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Membrane Trafficking, organism-specific biosystem (from REACTOME)
Membrane Trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MicroRNAs in cancer, organism-specific biosystem (from KEGG)
MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
MicroRNAs in cancer, conserved biosystem (from KEGG)
MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
NCAM signaling for neurite out-growth, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Negative regulation of FGFR1 signaling, organism-specific biosystem (from REACTOME)
Negative regulation of FGFR1 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Negative regulation of FGFR2 signaling, organism-specific biosystem (from REACTOME)
Negative regulation of FGFR2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Negative regulation of FGFR3 signaling, organism-specific biosystem (from REACTOME)
Negative regulation of FGFR3 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Negative regulation of FGFR4 signaling, organism-specific biosystem (from REACTOME)
Negative regulation of FGFR4 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Negative regulation of MET activity, organism-specific biosystem (from REACTOME)
Negative regulation of MET activity, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Negative regulation of the PI3K/AKT network, organism-specific biosystem (from REACTOME)
Negative regulation of the PI3K/AKT network, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
Neurotrophin signaling pathway, conserved biosystem (from KEGG)
Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
Non-small cell lung cancer, organism-specific biosystem (from KEGG)
Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
Non-small cell lung cancer, conserved biosystem (from KEGG)
Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
Osteoclast differentiation, organism-specific biosystem (from KEGG)
Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
Osteoclast differentiation, conserved biosystem (from KEGG)
Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
PI-3K cascade:FGFR1, organism-specific biosystem (from REACTOME)
PI-3K cascade:FGFR1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI-3K cascade:FGFR2, organism-specific biosystem (from REACTOME)
PI-3K cascade:FGFR2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI-3K cascade:FGFR3, organism-specific biosystem (from REACTOME)
PI-3K cascade:FGFR3, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI-3K cascade:FGFR4, organism-specific biosystem (from REACTOME)
PI-3K cascade:FGFR4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K Cascade, organism-specific biosystem (from REACTOME)
PI3K Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
PI3K events in ERBB2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K/AKT activation, organism-specific biosystem (from REACTOME)
PI3K/AKT activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, organism-specific biosystem (from REACTOME)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
PIP3 activates AKT signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
Phospholipase D signaling pathway, conserved biosystem (from KEGG)
Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
Platelet Aggregation (Plug Formation), organism-specific biosystem (from REACTOME)
Platelet Aggregation (Plug Formation), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PluriNetWork, organism-specific biosystem (from WikiPathways)
PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
Prolactin signaling pathway, organism-specific biosystem (from KEGG)
Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
Prolactin signaling pathway, conserved biosystem (from KEGG)
Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
Prolonged ERK activation events, organism-specific biosystem (from REACTOME)
Prolonged ERK activation events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Prostate cancer, organism-specific biosystem (from KEGG)
Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Prostate cancer, conserved biosystem (from KEGG)
Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
RAF/MAP kinase cascade, organism-specific biosystem (from REACTOME)
RAF/MAP kinase cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RET signaling, organism-specific biosystem (from REACTOME)
RET signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
RHO GTPase Effectors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RHO GTPases Activate WASPs and WAVEs, organism-specific biosystem (from REACTOME)
RHO GTPases Activate WASPs and WAVEs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ras signaling pathway, organism-specific biosystem (from KEGG)
Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
Regulation of KIT signaling, organism-specific biosystem (from REACTOME)
Regulation of KIT signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of signaling by CBL, organism-specific biosystem (from REACTOME)
Regulation of signaling by CBL, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Renal cell carcinoma, organism-specific biosystem (from KEGG)
Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
Renal cell carcinoma, conserved biosystem (from KEGG)
Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystem (from REACTOME)
Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SHC-mediated cascade:FGFR1, organism-specific biosystem (from REACTOME)
SHC-mediated cascade:FGFR1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SHC-mediated cascade:FGFR2, organism-specific biosystem (from REACTOME)
SHC-mediated cascade:FGFR2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SHC-mediated cascade:FGFR3, organism-specific biosystem (from REACTOME)
SHC-mediated cascade:FGFR3, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SHC-mediated cascade:FGFR4, organism-specific biosystem (from REACTOME)
SHC-mediated cascade:FGFR4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SHC-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
SHC-related events triggered by IGF1R, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SHC1 events in EGFR signaling, organism-specific biosystem (from REACTOME)
SHC1 events in EGFR signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SHC1 events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
SHC1 events in ERBB4 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
SOS-mediated signalling, organism-specific biosystem (from REACTOME)
SOS-mediated signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal attenuation, organism-specific biosystem (from REACTOME)
Signal attenuation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal regulatory protein (SIRP) family interactions, organism-specific biosystem (from REACTOME)
Signal regulatory protein (SIRP) family interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR, organism-specific biosystem (from REACTOME)
Signaling by EGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB2, organism-specific biosystem (from REACTOME)
Signaling by ERBB2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB4, organism-specific biosystem (from REACTOME)
Signaling by ERBB4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR, organism-specific biosystem (from REACTOME)
Signaling by FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR1, organism-specific biosystem (from REACTOME)
Signaling by FGFR1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR2, organism-specific biosystem (from REACTOME)
Signaling by FGFR2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR3, organism-specific biosystem (from REACTOME)
Signaling by FGFR3, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR4, organism-specific biosystem (from REACTOME)
Signaling by FGFR4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
Signaling by Insulin receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Interleukins, organism-specific biosystem (from REACTOME)
Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Leptin, organism-specific biosystem (from REACTOME)
Signaling by Leptin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by MET, organism-specific biosystem (from REACTOME)
Signaling by MET, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by PDGF, organism-specific biosystem (from REACTOME)
Signaling by PDGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
Signaling by Rho GTPases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
Signaling by SCF-KIT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by VEGF, organism-specific biosystem (from REACTOME)
Signaling by VEGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Signaling by the B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem (from WikiPathways)
Signaling of Hepatocyte Growth Factor Receptor, organism-specific biosystem
Signaling of Hepatocyte Growth Factor Receptor
Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling to ERKs, organism-specific biosystem (from REACTOME)
Signalling to ERKs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling to RAS, organism-specific biosystem (from REACTOME)
Signalling to RAS, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
Signalling to p38 via RIT and RIN, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Spry regulation of FGF signaling, organism-specific biosystem (from REACTOME)
Spry regulation of FGF signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
T cell receptor signaling pathway, conserved biosystem (from KEGG)
T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
Tie2 Signaling, organism-specific biosystem (from REACTOME)
Tie2 Signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
VEGFA-VEGFR2 Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
VEGFR2 mediated cell proliferation, organism-specific biosystem (from REACTOME)
VEGFR2 mediated cell proliferation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
Vesicle-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Viral carcinogenesis, organism-specific biosystem (from KEGG)
Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral carcinogenesis, conserved biosystem (from KEGG)
Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
mTOR signaling pathway, organism-specific biosystem (from KEGG)
mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
mTOR signaling pathway, conserved biosystem (from KEGG)
mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
p38 MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
p38 MAPK Signaling Pathway, organism-specific biosystemp38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133824 (e-PCR)
- UniSTS:217107

Grb2 (e-PCR), detects polymorphism
- UniSTS:143250

RH125419 (e-PCR)
- UniSTS:162241

RH124678 (e-PCR)
- UniSTS:161500

Homology

Homologs of the Grb2 gene: The Grb2 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 275 organisms have orthologs with human gene Grb2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
SH3 domain binding	ISO Inferred from Sequence Orthology more info
SH3/SH2 adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enzyme binding	ISO Inferred from Sequence Orthology more info
ephrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
ephrin receptor binding	ISO Inferred from Sequence Orthology more info
epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
identical protein binding	ISO Inferred from Sequence Orthology more info
insulin receptor substrate binding	ISO Inferred from Sequence Orthology more info
neurotrophin TRKA receptor binding	ISO Inferred from Sequence Orthology more info
phosphoprotein binding	ISO Inferred from Sequence Orthology more info
phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
protein domain specific binding	ISO Inferred from Sequence Orthology more info
protein kinase binding	ISO Inferred from Sequence Orthology more info
protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
Ras protein signal transduction	TAS Traceable Author Statement more info	PubMed
aging	ISO Inferred from Sequence Orthology more info
anatomical structure formation involved in morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
branching involved in labyrinthine layer morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of actin filament polymerization	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
protein heterooligomerization	ISO Inferred from Sequence Orthology more info
receptor internalization	ISO Inferred from Sequence Orthology more info
regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
signal transduction in response to DNA damage	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
COP9 signalosome	IDA Inferred from Direct Assay more info	PubMed
COP9 signalosome	ISO Inferred from Sequence Orthology more info
Golgi apparatus	IEA Inferred from Electronic Annotation more info
Grb2-EGFR complex	ISO Inferred from Sequence Orthology more info
cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
endosome	ISO Inferred from Sequence Orthology more info
membrane	IDA Inferred from Direct Assay more info	PubMed
nucleolus	ISO Inferred from Sequence Orthology more info
nucleoplasm	ISO Inferred from Sequence Orthology more info
nucleus	ISO Inferred from Sequence Orthology more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
protein-containing complex	ISO Inferred from Sequence Orthology more info
vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: growth factor receptor-bound protein 2

Names: SH2/SH3 adapter GRB2; adapter protein GRB2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313936.1 → NP_001300865.1 growth factor receptor-bound protein 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AK155800, BC052377, BQ174314, BY292622

Consensus CDS

CCDS25645.1

UniProtKB/Swiss-Prot

Q60631

UniProtKB/TrEMBL

Q3U1Q4, Q3U5I5

Conserved Domains (3) summary

cd09941
Location:56 → 150

SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins

cd11946
Location:1 → 56

SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

cd11949
Location:160 → 212

SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
NM_001313937.1 → NP_001300866.1 growth factor receptor-bound protein 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

AK155800, BC052377, BQ174314, BY266228

Consensus CDS

CCDS25645.1

UniProtKB/Swiss-Prot

Q60631

UniProtKB/TrEMBL

Q3U1Q4, Q3U5I5

Related

ENSMUSP00000102106.1, ENSMUST00000106497.7

Conserved Domains (3) summary

cd09941
Location:56 → 150

SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins

cd11946
Location:1 → 56

SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

cd11949
Location:160 → 212

SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
NM_008163.4 → NP_032189.1 growth factor receptor-bound protein 2

See identical proteins and their annotated locations for NP_032189.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

AK155800, BC052377, BQ174314

Consensus CDS

CCDS25645.1

UniProtKB/Swiss-Prot

Q60631

UniProtKB/TrEMBL

Q3U1Q4, Q3U5I5

Related

ENSMUSP00000021090.7, ENSMUST00000021090.13

Conserved Domains (3) summary

cd09941
Location:56 → 150

SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins

cd11946
Location:1 → 56

SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

cd11949
Location:160 → 212

SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2