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Gpx2 glutathione peroxidase 2 [ Mus musculus (house mouse) ]

Gene ID: 14776, updated on 16-Oct-2021

Summary

Official Symbol
Gpx2provided by MGI
Official Full Name
glutathione peroxidase 2provided by MGI
Primary source
MGI:MGI:106609
See related
Ensembl:ENSMUSG00000042808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GI-GPx; GPx-GI; GSHPx-2; GSHPx-GI
Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract in rodents, is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Knockout studies in mice lacking this gene suggest a role for this isozyme in intestinal inflammation and colon cancer development. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 7. [provided by RefSeq, Aug 2017]
Expression
Biased expression in large intestine adult (RPKM 1086.3), small intestine adult (RPKM 241.0) and 3 other tissues See more
Orthologs
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Genomic context

See Gpx2 in Genome Data Viewer
Location:
12 C3; 12 33.73 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76839109..76842328, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76792335..76795554, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (77893322..77896541, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene spectrin beta, erythrocytic Neighboring gene churchill domain containing 1 Neighboring gene RAB15, member RAS oncogene family Neighboring gene predicted gene, 34988 Neighboring gene farnesyltransferase, CAAX box, beta Neighboring gene predicted gene, 46357

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutathione peroxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables glutathione peroxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
glutathione peroxidase 2
Names
GPx-2
glutathione peroxidase-gastrointestinal
intestinal GPx
NP_109602.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030677.2NP_109602.2  glutathione peroxidase 2

    See identical proteins and their annotated locations for NP_109602.2

    Status: REVIEWED

    Source sequence(s)
    AK131940, BX629737, CF612186
    Consensus CDS
    CCDS25996.1
    UniProtKB/Swiss-Prot
    Q9JHC0
    Related
    ENSMUSP00000081012.5, ENSMUST00000082431.6
    Conserved Domains (1) summary
    cd00340
    Location:7182
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    76839109..76842328 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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