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Gpx1 glutathione peroxidase 1 [ Mus musculus (house mouse) ]

Gene ID: 14775, updated on 18-Sep-2018

Summary

Official Symbol
Gpx1provided by MGI
Official Full Name
glutathione peroxidase 1provided by MGI
Primary source
MGI:MGI:104887
See related
Ensembl:ENSMUSG00000063856 Vega:OTTMUSG00000050754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpx; CGPx; GPx-1; GSHPx-1; AI195024; AL033363
Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Knockout mice lacking this gene are highly sensitive to oxidants, and develop mature cataracts due to damage to the eye lens nucleus. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Expression
Broad expression in liver adult (RPKM 2481.2), liver E14.5 (RPKM 1548.2) and 19 other tissues See more
Orthologs

Genomic context

See Gpx1 in Genome Data Viewer
Location:
9 F2; 9 59.24 cM
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (108339080..108340342)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (108241607..108242671)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene T cell leukemia translocation altered gene Neighboring gene ras homolog family member A Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) Neighboring gene ribosomal protein S2, pseudogene 11 Neighboring gene RIKEN cDNA 1700102P08 gene Neighboring gene coiled-coil domain containing 36

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione peroxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
UV protection ISO
Inferred from Sequence Orthology
more info
 
angiogenesis involved in wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
endothelial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart contraction ISO
Inferred from Sequence Orthology
more info
 
hydrogen peroxide catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
interaction with symbiont IGI
Inferred from Genetic Interaction
more info
PubMed 
intrinsic apoptotic signaling pathway in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
myoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
myotube differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response to antigenic stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
 
regulation of mammary gland epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
response to gamma radiation IGI
Inferred from Genetic Interaction
more info
PubMed 
response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
response to hydroperoxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to selenium ion ISO
Inferred from Sequence Orthology
more info
 
response to symbiotic bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
temperature homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Lewy body ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutathione peroxidase 1
Names
cellular glutathione peroxidase
selenium-dependent glutathione peroxidase 1
NP_032186.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329527.1NP_001316456.1  glutathione peroxidase 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the 3' terminal exon compared to variant 1. The resulting isoform (2) is 1 amino acid shorter than isoform 1.
    Source sequence(s)
    BC086649, BY113381, CK628430
    UniProtKB/Swiss-Prot
    P11352
  2. NM_001329528.1NP_001316457.1  glutathione peroxidase 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is alternatively spliced in the 5' coding region, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The resulting isoform (3) has a shorter N-terminus lacking the selenocysteine residue compared to isoform 1.
    Source sequence(s)
    AW611014, BC086649, CK628430
    UniProtKB/Swiss-Prot
    P11352
    UniProtKB/TrEMBL
    A0A0A6YVV2
  3. NM_008160.6NP_032186.2  glutathione peroxidase 1 isoform 1

    See identical proteins and their annotated locations for NP_032186.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC086649, CK628430
    Consensus CDS
    CCDS23522.1
    UniProtKB/Swiss-Prot
    P11352
    Related
    ENSMUSP00000081010.5, OTTMUSP00000069174, ENSMUST00000082429.6, OTTMUST00000128632
    Conserved Domains (1) summary
    cd00340
    Location:13190
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    108339080..108340342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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