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LYPD4 LY6/PLAUR domain containing 4 [ Homo sapiens (human) ]

Gene ID: 147719, updated on 18-Aug-2020

Summary

Official Symbol
LYPD4provided by HGNC
Official Full Name
LY6/PLAUR domain containing 4provided by HGNC
Primary source
HGNC:HGNC:28659
See related
Ensembl:ENSG00000273111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMR
Expression
Restricted expression toward testis (RPKM 27.7) See more
Orthologs

Genomic context

See LYPD4 in Genome Data Viewer
Location:
19q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41833686..41845204, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42339356..42348774, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule 3 Neighboring gene CEA cell adhesion molecule 1 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 52 Neighboring gene DMRT like family C2 Neighboring gene ribosomal protein S19 Neighboring gene microRNA 6797 Neighboring gene CD79a molecule

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of LY6/PLAUR domain containing 4 (LYPD4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC42718, AC020956.3

Gene Ontology Provided by GOA

Component Evidence Code Pubs
anchored component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
plasma membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ly6/PLAUR domain-containing protein 4
Names
sperm membrane receptor
testicular tissue protein Li 159

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291419.2NP_001278348.1  ly6/PLAUR domain-containing protein 4 precursor

    See identical proteins and their annotated locations for NP_001278348.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the 5' UTR and coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC243967, BC034629
    Consensus CDS
    CCDS77303.1
    UniProtKB/Swiss-Prot
    Q6UWN0
    Related
    ENSP00000339568.4, ENST00000343055.5
    Conserved Domains (1) summary
    pfam00021
    Location:107177
    UPAR_LY6; u-PAR/Ly-6 domain
  2. NM_173506.7NP_775777.3  ly6/PLAUR domain-containing protein 4 precursor

    See identical proteins and their annotated locations for NP_775777.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC243967, AK292305, BC034629
    Consensus CDS
    CCDS12587.1
    UniProtKB/Swiss-Prot
    Q6UWN0
    UniProtKB/TrEMBL
    A8K8E0
    Related
    ENSP00000476510.1, ENST00000609812.6
    Conserved Domains (1) summary
    pfam00021
    Location:142212
    UPAR_LY6; u-PAR/Ly-6 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    41833686..41845204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451375.1XP_024307143.1  ly6/PLAUR domain-containing protein 4 isoform X5

    Conserved Domains (1) summary
    pfam00021
    Location:142212
    UPAR_LY6; u-PAR/Ly-6 domain
  2. XM_024451374.1XP_024307142.1  ly6/PLAUR domain-containing protein 4 isoform X5

    Conserved Domains (1) summary
    pfam00021
    Location:142212
    UPAR_LY6; u-PAR/Ly-6 domain
  3. XM_005278385.5XP_005278442.1  ly6/PLAUR domain-containing protein 4 isoform X3

    Conserved Domains (1) summary
    pfam00021
    Location:155225
    UPAR_LY6; u-PAR/Ly-6 domain
  4. XM_024451379.1XP_024307147.1  ly6/PLAUR domain-containing protein 4 isoform X7

    Conserved Domains (1) summary
    pfam00021
    Location:93163
    UPAR_LY6; u-PAR/Ly-6 domain
  5. XM_024451373.1XP_024307141.1  ly6/PLAUR domain-containing protein 4 isoform X4

    Conserved Domains (1) summary
    pfam00021
    Location:142212
    UPAR_LY6; u-PAR/Ly-6 domain
  6. XM_006723035.2XP_006723098.1  ly6/PLAUR domain-containing protein 4 isoform X2

    Conserved Domains (1) summary
    pfam00021
    Location:151221
    UPAR_LY6; u-PAR/Ly-6 domain
  7. XM_024451372.1XP_024307140.1  ly6/PLAUR domain-containing protein 4 isoform X4

    Conserved Domains (1) summary
    pfam00021
    Location:142212
    UPAR_LY6; u-PAR/Ly-6 domain
  8. XM_005258543.3XP_005258600.1  ly6/PLAUR domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_005258600.1

    Conserved Domains (1) summary
    pfam00021
    Location:155225
    UPAR_LY6; u-PAR/Ly-6 domain
  9. XM_005278388.4XP_005278445.1  ly6/PLAUR domain-containing protein 4 isoform X7

    See identical proteins and their annotated locations for XP_005278445.1

    Conserved Domains (1) summary
    pfam00021
    Location:93163
    UPAR_LY6; u-PAR/Ly-6 domain
  10. XM_005278383.5XP_005278440.1  ly6/PLAUR domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_005278440.1

    Conserved Domains (1) summary
    pfam00021
    Location:155225
    UPAR_LY6; u-PAR/Ly-6 domain
  11. XM_011526483.2XP_011524785.1  ly6/PLAUR domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011524785.1

    Conserved Domains (1) summary
    pfam00021
    Location:155225
    UPAR_LY6; u-PAR/Ly-6 domain
  12. XM_011526484.2XP_011524786.1  ly6/PLAUR domain-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011524786.1

    Conserved Domains (1) summary
    pfam00021
    Location:155225
    UPAR_LY6; u-PAR/Ly-6 domain
  13. XM_024451378.1XP_024307146.1  ly6/PLAUR domain-containing protein 4 isoform X8

    Conserved Domains (1) summary
    cl10471
    Location:142179
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  14. XM_024451377.1XP_024307145.1  ly6/PLAUR domain-containing protein 4 isoform X8

    Conserved Domains (1) summary
    cl10471
    Location:142179
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  15. XM_024451376.1XP_024307144.1  ly6/PLAUR domain-containing protein 4 isoform X8

    Conserved Domains (1) summary
    cl10471
    Location:142179
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
  16. XM_005278387.5XP_005278444.1  ly6/PLAUR domain-containing protein 4 isoform X6

    Conserved Domains (1) summary
    cl10471
    Location:155192
    LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
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