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KLC3 kinesin light chain 3 [ Homo sapiens (human) ]

Gene ID: 147700, updated on 1-Jun-2020

Summary

Official Symbol
KLC3provided by HGNC
Official Full Name
kinesin light chain 3provided by HGNC
Primary source
HGNC:HGNC:20717
See related
Ensembl:ENSG00000104892 MIM:601334
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLC2; KLCt; KLC2L; KNS2B
Summary
This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 20.7), esophagus (RPKM 4.3) and 4 other tissues See more
Orthologs

Genomic context

See KLC3 in Genome Data Viewer
Location:
19q13.32
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45340750..45351548)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45843998..45854864)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene heart enhancer 22 Neighboring gene ribosomal protein S16 pseudogene 9 Neighboring gene ERCC excision repair 2, TFIIH core complex helicase subunit Neighboring gene protein phosphatase 1 regulatory subunit 13 like Neighboring gene RNA polymerase I subunit G Neighboring gene ERCC excision repair 1, endonuclease non-catalytic subunit

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kinesin binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
axo-dendritic transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ciliary rootlet IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
kinesin complex IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
motile cilium IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinesin light chain 3
Names
kinesin light chain 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177417.3NP_803136.2  kinesin light chain 3

    See identical proteins and their annotated locations for NP_803136.2

    Status: REVIEWED

    Source sequence(s)
    AK092481, BC062998, BF569806
    Consensus CDS
    CCDS12660.2
    UniProtKB/Swiss-Prot
    Q6P597
    UniProtKB/TrEMBL
    A0A024R0V3
    Related
    ENSP00000375810.2, ENST00000391946.7
    Conserved Domains (4) summary
    sd00006
    Location:291319
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:375402
    TPR_1; Tetratricopeptide repeat
    pfam13374
    Location:290331
    TPR_10; Tetratricopeptide repeat
    pfam13424
    Location:245323
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    45340750..45351548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451370.1XP_024307138.1  kinesin light chain 3 isoform X2

    Conserved Domains (3) summary
    sd00006
    Location:291319
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:247323
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:21148
    SMC_N; RecF/RecN/SMC N terminal domain
  2. XM_024451369.1XP_024307137.1  kinesin light chain 3 isoform X1

    Conserved Domains (3) summary
    sd00006
    Location:342370
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:298374
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:72199
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_024451371.1XP_024307139.1  kinesin light chain 3 isoform X3

    Conserved Domains (3) summary
    sd00006
    Location:342370
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:298374
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:112199
    SMC_N; RecF/RecN/SMC N terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145275.1: Suppressed sequence

    Description
    NM_145275.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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