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ZNF418 zinc finger protein 418 [ Homo sapiens (human) ]

Gene ID: 147686, updated on 5-Jan-2022

Summary

Official Symbol
ZNF418provided by HGNC
Official Full Name
zinc finger protein 418provided by HGNC
Primary source
HGNC:HGNC:20647
See related
Ensembl:ENSG00000196724 MIM:619509
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP418
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in thyroid (RPKM 1.8), skin (RPKM 1.6) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF418 in Genome Data Viewer
Location:
19q13.43
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (57921882..57935403, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58433250..58446770, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 814 Neighboring gene zinc finger protein 417 Neighboring gene zinc finger protein 256 Neighboring gene ribosomal protein L19 pseudogene 19

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31551, KIAA1956, MGC138449

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317027.2NP_001303956.1  zinc finger protein 418 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC010326, AK293723, AY695825
    Consensus CDS
    CCDS82410.1
    UniProtKB/Swiss-Prot
    Q8TF45
    UniProtKB/TrEMBL
    B7Z1P3, J3KQR4
    Related
    ENSP00000407039.2, ENST00000425570.7
    Conserved Domains (5) summary
    smart00349
    Location:2667
    KRAB; krueppel associated box
    COG5048
    Location:304692
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:505525
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2665
    KRAB; KRAB box
    pfam13465
    Location:433458
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001317028.2NP_001303957.1  zinc finger protein 418 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC010326, AK293723, AY695825, DA961678
    UniProtKB/Swiss-Prot
    Q8TF45
    UniProtKB/TrEMBL
    B7Z1P3
    Conserved Domains (5) summary
    smart00349
    Location:647
    KRAB; krueppel associated box
    COG5048
    Location:284672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:485505
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:413438
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001317029.2NP_001303958.1  zinc finger protein 418 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AC010326, AK293723, AY695825, DA113968
    Consensus CDS
    CCDS42642.1
    UniProtKB/Swiss-Prot
    Q8TF45
    UniProtKB/TrEMBL
    B7Z1P3
    Conserved Domains (3) summary
    COG5048
    Location:283671
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:445
    KRAB; KRAB box
  4. NM_001317030.2NP_001303959.1  zinc finger protein 418 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks three alternate exons compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC010326, AK293723, AK304632, AY695825
    Consensus CDS
    CCDS82409.1
    UniProtKB/Swiss-Prot
    Q8TF45
    UniProtKB/TrEMBL
    B7Z1P3, B7Z993, M0QX82
    Related
    ENSP00000468968.1, ENST00000599852.1
    Conserved Domains (3) summary
    COG5048
    Location:198586
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:399419
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:327352
    zf-H2C2_2; Zinc-finger double domain
  5. NM_133460.3NP_597717.1  zinc finger protein 418 isoform c

    See identical proteins and their annotated locations for NP_597717.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate 5' exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AC010326, AK293723, AY695825
    Consensus CDS
    CCDS42642.1
    UniProtKB/Swiss-Prot
    Q8TF45
    UniProtKB/TrEMBL
    B7Z1P3
    Related
    ENSP00000379451.1, ENST00000396147.6
    Conserved Domains (3) summary
    COG5048
    Location:283671
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:445
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    57921882..57935403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026306.2XP_016881795.1  zinc finger protein 418 isoform X2

  2. XM_017026305.2XP_016881794.1  zinc finger protein 418 isoform X1

    UniProtKB/TrEMBL
    J3KQR4
    Conserved Domains (5) summary
    smart00349
    Location:2667
    KRAB; krueppel associated box
    COG5048
    Location:304692
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:505525
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2665
    KRAB; KRAB box
    pfam13465
    Location:433458
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017026311.1XP_016881800.1  zinc finger protein 418 isoform X4

    Conserved Domains (5) summary
    smart00349
    Location:647
    KRAB; krueppel associated box
    COG5048
    Location:284672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:485505
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:413438
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017026310.1XP_016881799.1  zinc finger protein 418 isoform X4

    Conserved Domains (5) summary
    smart00349
    Location:647
    KRAB; krueppel associated box
    COG5048
    Location:284672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:485505
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:413438
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017026313.1XP_016881802.1  zinc finger protein 418 isoform X5

    UniProtKB/Swiss-Prot
    Q8TF45
    Conserved Domains (3) summary
    COG5048
    Location:283671
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:445
    KRAB; KRAB box
  6. XM_017026304.2XP_016881793.1  zinc finger protein 418 isoform X1

    UniProtKB/TrEMBL
    J3KQR4
    Conserved Domains (5) summary
    smart00349
    Location:2667
    KRAB; krueppel associated box
    COG5048
    Location:304692
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:505525
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2665
    KRAB; KRAB box
    pfam13465
    Location:433458
    zf-H2C2_2; Zinc-finger double domain
  7. XM_017026314.2XP_016881803.1  zinc finger protein 418 isoform X6

  8. XM_017026308.2XP_016881797.1  zinc finger protein 418 isoform X3

  9. XM_017026312.1XP_016881801.1  zinc finger protein 418 isoform X5

    UniProtKB/Swiss-Prot
    Q8TF45
    Related
    ENSP00000483763.1, ENST00000616958.1
    Conserved Domains (3) summary
    COG5048
    Location:283671
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:445
    KRAB; KRAB box
  10. XM_017026309.1XP_016881798.1  zinc finger protein 418 isoform X4

    Conserved Domains (5) summary
    smart00349
    Location:647
    KRAB; krueppel associated box
    COG5048
    Location:284672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:485505
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:645
    KRAB; KRAB box
    pfam13465
    Location:413438
    zf-H2C2_2; Zinc-finger double domain
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