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ZNF578 zinc finger protein 578 [ Homo sapiens (human) ]

Gene ID: 147660, updated on 23-Nov-2021

Summary

Official Symbol
ZNF578provided by HGNC
Official Full Name
zinc finger protein 578provided by HGNC
Primary source
HGNC:HGNC:26449
See related
Ensembl:ENSG00000258405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 3.0), thyroid (RPKM 0.7) and 14 other tissues See more
Orthologs
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Genomic context

See ZNF578 in Genome Data Viewer
Location:
19q13.41
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (52453553..52516882)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52956806..53020135)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene developmental pluripotency associated 5 pseudogene 1 Neighboring gene zinc finger protein 534 Neighboring gene DUT pseudogene Neighboring gene zinc finger protein 347 pseudogene Neighboring gene zinc finger protein 808 Neighboring gene ribosomal protein L39 pseudogene 34 Neighboring gene zinc finger protein 701 Neighboring gene zinc finger protein 137, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31384

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099694.2NP_001093164.1  zinc finger protein 578

    See identical proteins and their annotated locations for NP_001093164.1

    Status: VALIDATED

    Source sequence(s)
    AC010332, AC022150, AK055946, BC115704, BX955279
    Consensus CDS
    CCDS54310.1
    UniProtKB/Swiss-Prot
    Q96N58
    UniProtKB/TrEMBL
    Q3MI94
    Related
    ENSP00000459216.1, ENST00000421239.7
    Conserved Domains (3) summary
    COG5048
    Location:257582
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2464
    KRAB; KRAB box
  2. NM_001366182.2NP_001353111.1  zinc finger protein 578

    Status: VALIDATED

    Source sequence(s)
    AC010332, AC010506, AC022150
    Conserved Domains (3) summary
    COG5048
    Location:257582
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2464
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    52453553..52516882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_152472.1: Suppressed sequence

    Description
    NM_152472.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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