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ZNF534 zinc finger protein 534 [ Homo sapiens (human) ]

Gene ID: 147658, updated on 5-Jan-2022

Summary

Official Symbol
ZNF534provided by HGNC
Official Full Name
zinc finger protein 534provided by HGNC
Primary source
HGNC:HGNC:26337
See related
Ensembl:ENSG00000198633
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KRBO3
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ZNF534 in Genome Data Viewer
Location:
19q13.41
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (52429148..52452263)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52932401..52955516)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 880 Neighboring gene ZNF528 antisense RNA 1 Neighboring gene zinc finger protein 528 Neighboring gene developmental pluripotency associated 5 pseudogene 1 Neighboring gene DUT pseudogene Neighboring gene zinc finger protein 578 Neighboring gene zinc finger protein 347 pseudogene Neighboring gene zinc finger protein 808 Neighboring gene ribosomal protein L39 pseudogene 34

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ25344

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 534
Names
KRAB domain only 3
KRAB domain only protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054923.1 RefSeqGene

    Range
    5178..18529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001143938.3NP_001137410.1  zinc finger protein 534 isoform 1

    See identical proteins and their annotated locations for NP_001137410.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AB086839, AC010332
    Consensus CDS
    CCDS46166.1
    UniProtKB/Swiss-Prot
    Q76KX8
    Related
    ENSP00000391358.1, ENST00000433050.6
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:198596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:524544
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:452477
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001143939.3NP_001137411.1  zinc finger protein 534 isoform 2

    See identical proteins and their annotated locations for NP_001137411.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region compared to variant 1. Variant 2 represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AB086840, AC010332
    Consensus CDS
    CCDS46165.1
    UniProtKB/Swiss-Prot
    Q76KX8
    Related
    ENSP00000327538.6, ENST00000332323.10
    Conserved Domains (5) summary
    smart00349
    Location:881
    KRAB; krueppel associated box
    COG5048
    Location:211609
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:537557
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:465490
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001291368.4NP_001278297.1  zinc finger protein 534 isoform 3

    See identical proteins and their annotated locations for NP_001278297.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' exon in the 3' UTR and 3' coding region compared to variant 1. The encoded isoform (3) is shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB091369, AC010332, AK058073
    Consensus CDS
    CCDS77347.1
    UniProtKB/TrEMBL
    Q1T7F5
    Related
    ENSP00000301085.4, ENST00000301085.8
    Conserved Domains (2) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    pfam01352
    Location:847
    KRAB; KRAB box
  4. NM_001291369.4NP_001278298.1  zinc finger protein 534 isoform 4

    See identical proteins and their annotated locations for NP_001278298.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the internal coding region and uses an alternate exon in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB091368, AC010332, AK058073
    Consensus CDS
    CCDS77348.1
    UniProtKB/TrEMBL
    Q1T7F6
    Related
    ENSP00000409421.2, ENST00000432303.6
    Conserved Domains (2) summary
    smart00349
    Location:849
    KRAB; krueppel associated box
    pfam01352
    Location:847
    KRAB; KRAB box
  5. NM_001351679.2NP_001338608.1  zinc finger protein 534 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate coding exon compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC010332
    Conserved Domains (2) summary
    COG5048
    Location:239633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:496516
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    52429148..52452263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182512.1: Suppressed sequence

    Description
    NM_182512.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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