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SPACA6 sperm acrosome associated 6 [ Homo sapiens (human) ]

Gene ID: 147650, updated on 23-Nov-2021

Summary

Official Symbol
SPACA6provided by HGNC
Official Full Name
sperm acrosome associated 6provided by HGNC
Primary source
HGNC:HGNC:27113
See related
Ensembl:ENSG00000182310 MIM:618945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LET7EH; SPACA6P; LINC00085; NCRNA00085
Expression
Broad expression in testis (RPKM 2.0), placenta (RPKM 1.7) and 22 other tissues See more
Orthologs
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Genomic context

See SPACA6 in Genome Data Viewer
Location:
19q13.41
Exon count:
12
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51685595..51713157)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52192635..52208443)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig like lectin 14 Neighboring gene ribosomal protein L7 pseudogene 51 Neighboring gene SPACA6 antisense RNA 1 Neighboring gene microRNA let-7e Neighboring gene microRNA 125a Neighboring gene microRNA 99b Neighboring gene hyaluronan synthase 1 Neighboring gene formyl peptide receptor 1 Neighboring gene formyl peptide receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC125919, MGC125920

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sperm acrosome membrane-associated protein 6
Names
BACHELOR-like protein
Let-7e host
long intergenic non-protein coding RNA 85
sperm acrosome associated 6, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316972.2NP_001303901.1  sperm acrosome membrane-associated protein 6 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC018755, BC041134, KF751883
    Consensus CDS
    CCDS82386.1
    UniProtKB/Swiss-Prot
    W5XKT8
    Related
    ENSP00000490829.1, ENST00000637797.2
    Conserved Domains (3) summary
    smart00410
    Location:156229
    IG_like; Immunoglobulin like
    pfam02480
    Location:212320
    Herpes_gE; Alphaherpesvirus glycoprotein E
    pfam13927
    Location:155229
    Ig_3; Immunoglobulin domain
  2. NM_001316994.2NP_001303923.1  sperm acrosome membrane-associated protein 6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate exon in the 5' UTR and 5' coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC018755
    Conserved Domains (3) summary
    smart00410
    Location:115188
    IG_like; Immunoglobulin like
    pfam02480
    Location:171279
    Herpes_gE; Alphaherpesvirus glycoprotein E
    pfam13927
    Location:114188
    Ig_3; Immunoglobulin domain

RNA

  1. NR_024330.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC018755, AY358799, BC041134
    Related
    ENST00000573266.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    51685595..51713157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026300.2XP_016881789.1  sperm acrosome membrane-associated protein 6 isoform X2

  2. XM_017026299.2XP_016881788.1  sperm acrosome membrane-associated protein 6 isoform X1

    UniProtKB/Swiss-Prot
    W5XKT8
    Conserved Domains (3) summary
    smart00410
    Location:156229
    IG_like; Immunoglobulin like
    pfam02480
    Location:212320
    Herpes_gE; Alphaherpesvirus glycoprotein E
    pfam13927
    Location:155229
    Ig_3; Immunoglobulin domain
  3. XM_017026301.1XP_016881790.1  sperm acrosome membrane-associated protein 6 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207324.1: Suppressed sequence

    Description
    NM_207324.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
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