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Gpi1 glucose-6-phosphate isomerase 1 [ Mus musculus (house mouse) ]

Gene ID: 14751, updated on 26-Sep-2022

Summary

Official Symbol
Gpi1provided by MGI
Official Full Name
glucose-6-phosphate isomerase 1provided by MGI
Primary source
MGI:MGI:95797
See related
Ensembl:ENSMUSG00000036427 AllianceGenome:MGI:95797
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MF; NK; Amf; Gpi; Nlk; Org; Pgi; Phi; Gpi-1; Gpi1s; Gpi-1r; Gpi-1s; Gpi-1t; Gpi1-r; Gpi1-s; Gpi1-t; NK/GPI
Summary
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in testis adult (RPKM 145.1), duodenum adult (RPKM 123.0) and 28 other tissues See more
Orthologs
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Genomic context

See Gpi1 in Genome Data Viewer
Location:
7 B1; 7 19.46 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (33900752..33929761, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (34201327..34230336, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene programmed cell death 2-like Neighboring gene predicted gene 12762 Neighboring gene predicted gene 12758 Neighboring gene granule associated Rac and RHOG effector 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC113776

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate derivative binding IEA
Inferred from Electronic Annotation
more info
 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables glucose-6-phosphate isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glucose-6-phosphate isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glucose-6-phosphate isomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables glucose-6-phosphate isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables monosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables monosaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in canonical glycolysis TAS
Traceable Author Statement
more info
PubMed 
involved_in carbohydrate derivative metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within erythrocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glucose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within glycolytic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glycolytic process through glucose-6-phosphate IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
involved_in response to morphine ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in ciliary membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
located_in myelin sheath HDA PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glucose-6-phosphate isomerase
Names
autocrine motility factor
glucose phosphate isomerase 1 complex
glucose phosphate isomerase 1, regulatory
glucose phosphate isomerase 1, structural
glucose phosphate isomerase 1, temporal
maturation factor
neuroleukin
phosphoglucose isomerase
phosphohexose isomerase
NP_032181.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008155.4NP_032181.2  glucose-6-phosphate isomerase

    See identical proteins and their annotated locations for NP_032181.2

    Status: REVIEWED

    Source sequence(s)
    AK031081, AK147124, BY350616
    Consensus CDS
    CCDS21138.1
    UniProtKB/Swiss-Prot
    P06745, Q9JM07
    Related
    ENSMUSP00000049355.5, ENSMUST00000038027.6
    Conserved Domains (3) summary
    PRK00179
    Location:1554
    pgi; glucose-6-phosphate isomerase; Reviewed
    cd05015
    Location:123286
    SIS_PGI_1; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...
    cd05016
    Location:334525
    SIS_PGI_2; Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    33900752..33929761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)