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S1pr2 sphingosine-1-phosphate receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 14739, updated on 8-Dec-2022

Summary

Official Symbol
S1pr2provided by MGI
Official Full Name
sphingosine-1-phosphate receptor 2provided by MGI
Primary source
MGI:MGI:99569
See related
Ensembl:ENSMUSG00000043895 AllianceGenome:MGI:99569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Edg5; H218; LPb2; S1P2; Gpcr13; 1100001A16Rik
Summary
Predicted to enable G protein-coupled receptor activity and signaling receptor binding activity. Involved in positive regulation of peptidyl-threonine phosphorylation and sphingosine-1-phosphate receptor signaling pathway. Acts upstream of or within negative regulation of excitatory postsynaptic potential. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Used to study autosomal recessive nonsyndromic deafness 68 and non-Hodgkin lymphoma. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 68. Orthologous to human S1PR2 (sphingosine-1-phosphate receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 19.6), limb E14.5 (RPKM 17.0) and 24 other tissues See more
Orthologs
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Genomic context

See S1pr2 in Genome Data Viewer
Location:
9 A3; 9 7.68 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20877248..20888089, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20965952..20976793, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3, subunit G Neighboring gene DNA methyltransferase (cytosine-5) 1 Neighboring gene microRNA 7081 Neighboring gene mitochondrial ribosomal protein L4 Neighboring gene intercellular adhesion molecule 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sphingosine-1-phosphate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sphingosine-1-phosphate receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in sphingosine-1-phosphate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sphingosine-1-phosphate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sphingosine-1-phosphate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
sphingosine 1-phosphate receptor 2
Names
G-protein coupled receptor 13
S1P receptor 2
S1P receptor Edg-5
endothelial differentiation G-protein coupled receptor 5
endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
lysophospholipid receptor B2
sphingosine 1-phosphate receptor Edg-5
sphingosine-1-phosphate receptor S1P(2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010333.4NP_034463.2  sphingosine 1-phosphate receptor 2

    See identical proteins and their annotated locations for NP_034463.2

    Status: VALIDATED

    Source sequence(s)
    AK151062, BY095108
    Consensus CDS
    CCDS22888.1
    UniProtKB/Swiss-Prot
    P52592, Q9R236
    Related
    ENSMUSP00000053394.6, ENSMUST00000054197.7
    Conserved Domains (2) summary
    cd14964
    Location:3660
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:35299
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    20877248..20888089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510019.5XP_006510082.1  sphingosine 1-phosphate receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_006510082.1

    UniProtKB/Swiss-Prot
    P52592, Q9R236
    Conserved Domains (2) summary
    cd14964
    Location:3660
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:35299
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily