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C18orf25 chromosome 18 open reading frame 25 [ Homo sapiens (human) ]

Gene ID: 147339, updated on 10-Oct-2019

Summary

Official Symbol
C18orf25provided by HGNC
Official Full Name
chromosome 18 open reading frame 25provided by HGNC
Primary source
HGNC:HGNC:28172
See related
Ensembl:ENSG00000152242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARKL1; Ark2N; RNF111L1
Expression
Ubiquitous expression in esophagus (RPKM 12.5), bone marrow (RPKM 9.9) and 25 other tissues See more
Orthologs

Genomic context

See C18orf25 in Genome Data Viewer
Location:
18q21.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (46173553..46266992)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (43753519..43846955)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene tRNA-Lys (CTT) 6-1 Neighboring gene ATP synthase F1 subunit alpha Neighboring gene RNA, U6 small nuclear 1278, pseudogene Neighboring gene HAUS augmin like complex subunit 1 Neighboring gene ring finger protein 165 Neighboring gene uncharacterized LOC105372095 Neighboring gene lipoxygenase homology domains 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12909, MGC87799

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
uncharacterized protein C18orf25
Names
ARKadia-like 1
ARKadia-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008239.2NP_001008240.1  uncharacterized protein C18orf25 isoform b

    See identical proteins and their annotated locations for NP_001008240.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AI374757, BC084579, BM561576, DA818562, DB284444
    Consensus CDS
    CCDS42431.1
    UniProtKB/Swiss-Prot
    Q96B23
    Related
    ENSP00000480074.1, ENST00000619301.4
    Conserved Domains (1) summary
    pfam15303
    Location:67238
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  2. NM_145055.5NP_659492.1  uncharacterized protein C18orf25 isoform a

    See identical proteins and their annotated locations for NP_659492.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC021763, AC118647, KF573673
    Consensus CDS
    CCDS42430.1
    UniProtKB/Swiss-Prot
    Q96B23
    UniProtKB/TrEMBL
    Q5BIX2
    Related
    ENSP00000481626.1, ENST00000615052.5
    Conserved Domains (1) summary
    pfam15303
    Location:67238
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    46173553..46266992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525822.2XP_011524124.1  uncharacterized protein C18orf25 isoform X1

    See identical proteins and their annotated locations for XP_011524124.1

    UniProtKB/Swiss-Prot
    Q96B23
    UniProtKB/TrEMBL
    Q5BIX2
    Conserved Domains (1) summary
    pfam15303
    Location:67238
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  2. XM_017025555.1XP_016881044.1  uncharacterized protein C18orf25 isoform X2

    UniProtKB/Swiss-Prot
    Q96B23
    Conserved Domains (1) summary
    pfam15303
    Location:67238
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
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