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Lilrb4a leukocyte immunoglobulin-like receptor, subfamily B, member 4A [ Mus musculus (house mouse) ]

Gene ID: 14728, updated on 8-Dec-2022

Summary

Official Symbol
Lilrb4aprovided by MGI
Official Full Name
leukocyte immunoglobulin-like receptor, subfamily B, member 4Aprovided by MGI
Primary source
MGI:MGI:102701
See related
Ensembl:ENSMUSG00000062593 Ensembl:ENSMUSG00000112148 AllianceGenome:MGI:102701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HM18; ILT3; gp49; CD85K; Gp49b; LIR-5; Lilrb4
Summary
Enables integrin binding activity. Involved in negative regulation of mast cell activation involved in immune response. Acts upstream of or within several processes, including alpha-beta T cell proliferation; cellular response to lipopolysaccharide; and response to nematode. Located in external side of plasma membrane. Is expressed in urinary system. Orthologous to human LILRB4 (leukocyte immunoglobulin like receptor B4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E18 (RPKM 6.7), lung adult (RPKM 6.6) and 20 other tissues See more
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Genomic context

See Lilrb4a in Genome Data Viewer
Location:
10 B3; 10 25.5 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (51366994..51372709)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (51490898..51496613)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene leukocyte immunoglobulin-like receptor subfamily A member 6 Neighboring gene leukocyte immunoglobulin-like receptor, subfamily B, member 4B Neighboring gene predicted gene, 40645 Neighboring gene predicted gene, 46224 Neighboring gene family with sequence similarity 162, member B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (5) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane receptor protein tyrosine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within CD4-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within CD8-positive, alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Fc receptor mediated inhibitory signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood coagulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of IP-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell costimulation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytotoxic T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mast cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mast cell activation involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mast cell activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mast cell activation involved in immune response IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in negative regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of monocyte activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of monocyte activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of natural killer cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of plasma cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neutrophil homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell anergy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to extracellular stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to nematode IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to other organism IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tolerance induction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within type 2 immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
leukocyte immunoglobulin-like receptor subfamily B member 4A; leukocyte immunoglobulin-like receptor subfamily B member 4
Names
glycoprotein 49 B
leukocyte immunoglobulin-like receptor, subfamily B, member 4
mast cell surface glycoprotein Gp49B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291894.1NP_001278823.1  leukocyte immunoglobulin-like receptor subfamily B member 4A isoform 2

    See identical proteins and their annotated locations for NP_001278823.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the first exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC153530, BC099532, BY749633
    Conserved Domains (1) summary
    cl11960
    Location:37131
    Ig; Immunoglobulin domain
  2. NM_013532.3NP_038560.1  leukocyte immunoglobulin-like receptor subfamily B member 4A isoform 1 precursor

    See identical proteins and their annotated locations for NP_038560.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC153530, BC099532
    Consensus CDS
    CCDS23832.1
    UniProtKB/Swiss-Prot
    Q64281, Q64312
    Related
    ENSMUSP00000077833.4, ENSMUST00000078778.5
    Conserved Domains (1) summary
    cl11960
    Location:27118
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    51366994..51372709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155620.1XP_036011513.1  leukocyte immunoglobulin-like receptor subfamily B member 4 isoform X1

    Related
    ENSMUSP00000151827.2, ENSMUST00000218123.2
    Conserved Domains (2) summary
    cd00096
    Location:2933
    Ig; Ig strand A [structural motif]
    cl11960
    Location:28116
    Ig; Immunoglobulin domain

RNA

  1. XR_871431.4 RNA Sequence

  2. XR_001779463.3 RNA Sequence

  3. XR_004936101.1 RNA Sequence

  4. XR_871432.4 RNA Sequence

    Related
    ENSMUST00000218617.2
  5. XR_871433.4 RNA Sequence