Lilrb4a leukocyte immunoglobulin-like receptor, subfamily B, member 4A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lilrb4aprovided by MGI
Official Full Name: leukocyte immunoglobulin-like receptor, subfamily B, member 4Aprovided by MGI
Primary source: MGI:MGI:102701
See related: Ensembl:ENSMUSG00000062593 Ensembl:ENSMUSG00000112148 AllianceGenome:MGI:102701
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HM18; ILT3; gp49; CD85K; Gp49b; LIR-5; Lilrb4
Summary: Enables fibronectin binding activity; integrin binding activity; and protein phosphatase binding activity. Involved in negative regulation of immunoglobulin production and negative regulation of leukocyte activation. Acts upstream of or within several processes, including alpha-beta T cell proliferation; cellular response to lipopolysaccharide; and response to nematode. Located in external side of plasma membrane. Is expressed in urinary system. Orthologous to human LILRB4 (leukocyte immunoglobulin like receptor B4). [provided by Alliance of Genome Resources, Mar 2025]
Expression: Broad expression in liver E18 (RPKM 6.7), lung adult (RPKM 6.6) and 20 other tissues See more
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Genomic context

Location:: 10 B3; 10 25.5 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (51366999..51372709)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (51490898..51496613)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leukocyte Ig-like receptor B4 (Lilrb4a) alleviates cardiac dysfunction and isoproterenol-induced arrhythmogenic remodeling associated with cardiac fibrosis and inflammation.
Title: Leukocyte Ig-like receptor B4 (Lilrb4a) alleviates cardiac dysfunction and isoproterenol-induced arrhythmogenic remodeling associated with cardiac fibrosis and inflammation.
LILRB4 knockdown inhibits aortic dissection development by regulating pyroptosis and the JAK2/STAT3 signaling pathway.
Title: LILRB4 knockdown inhibits aortic dissection development by regulating pyroptosis and the JAK2/STAT3 signaling pathway.
Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors.
Title: Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors.
LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection.
Title: LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection.
Fibronectin-LILRB4/gp49B interaction negatively regulates osteoclastogenesis through inhibition of RANKL-induced TRAF6/TAK1/NF-kB/MAPK signaling.
Title: Fibronectin-LILRB4/gp49B interaction negatively regulates osteoclastogenesis through inhibition of RANKL-induced TRAF6/TAK1/NF-kB/MAPK signaling.
LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal Adhesion Sites on Mast Cells.
Title: LILRB4/gp49B Co-Localizes with Integrin via Fibronectin at Focal Adhesion Sites on Mast Cells.
NK cells require immune checkpoint receptor LILRB4/gp49B to control neurotropic Zika virus infections in mice.
Title: NK cells require immune checkpoint receptor LILRB4/gp49B to control neurotropic Zika virus infections in mice.
Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice.
Title: Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice.
The leukocyte immunoglobulin-like receptor gp49B1, coexpressed with c-Kit, modulates hematopoiesis and B cell leukemia development.
Title: The leukocyte immunoglobulin-like receptor gp49B1, coexpressed with c-Kit, modulates hematopoiesis and B cell leukemia development.
Leukocyte immunoglobulin-like receptor B4 protects against cardiac hypertrophy via SHP-2-dependent inhibition of the NF-kappaB pathway.
Title: Leukocyte immunoglobulin-like receptor B4 protects against cardiac hypertrophy via SHP-2-dependent inhibition of the NF-κB pathway.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236349

U05265 (e-PCR)
- UniSTS:159979

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	IDA Inferred from Direct Assay more info	PubMed
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor inhibitor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CD4-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within CD8-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Fc receptor mediated inhibitory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of IP-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell costimulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytotoxic T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mast cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mast cell activation involved in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mast cell activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mast cell activation involved in immune response	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of monocyte activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of monocyte activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of natural killer cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of plasma cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signaling receptor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell anergy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in receptor internalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to nematode	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to other organism	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tolerance induction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within type 2 immune response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leukocyte immunoglobulin-like receptor subfamily B member 4A

Names: glycoprotein 49 B; leukocyte immunoglobulin-like receptor, subfamily B, member 4; mast cell surface glycoprotein Gp49B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291894.2 → NP_001278823.1 leukocyte immunoglobulin-like receptor subfamily B member 4A isoform 2

See identical proteins and their annotated locations for NP_001278823.1

Status: VALIDATED

Source sequence(s)

AC153530

UniProtKB/TrEMBL

A0A1W2P6F1

Conserved Domains (1) summary

cl11960
Location:37 → 131

Ig; Immunoglobulin domain
NM_013532.4 → NP_038560.1 leukocyte immunoglobulin-like receptor subfamily B member 4A isoform 1 precursor

See identical proteins and their annotated locations for NP_038560.1

Status: VALIDATED

Source sequence(s)

AC153530

Consensus CDS

CCDS23832.1

UniProtKB/Swiss-Prot

Q64281, Q64312

UniProtKB/TrEMBL

A0A1W2P7X1

Related

ENSMUSP00000077833.4, ENSMUST00000078778.5

Conserved Domains (1) summary

cl11960
Location:27 → 118

Ig; Immunoglobulin domain

RNA

NR_190388.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC153530

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

51366999..51372709

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155620.1 → XP_036011513.1 leukocyte immunoglobulin-like receptor subfamily B member 4A isoform X1

UniProtKB/TrEMBL

A0A1W2P7X1

Related

ENSMUSP00000151827.2, ENSMUST00000218123.2

Conserved Domains (2) summary

cd00096
Location:29 → 33

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 116

Ig; Immunoglobulin domain