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Lilrb4b leukocyte immunoglobulin-like receptor, subfamily B, member 4B [ Mus musculus (house mouse) ]

Gene ID: 14727, updated on 24-Jan-2023

Summary

Official Symbol
Lilrb4bprovided by MGI
Official Full Name
leukocyte immunoglobulin-like receptor, subfamily B, member 4Bprovided by MGI
Primary source
MGI:MGI:102702
See related
Ensembl:ENSMUSG00000112023 AllianceGenome:MGI:102702
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gp49; Gp49a; Lilr4b
Summary
Predicted to enable protein phosphatase binding activity and transmembrane receptor protein tyrosine kinase inhibitor activity. Predicted to be involved in several processes, including negative regulation of cytokine production; regulation of leukocyte activation; and regulation of signal transduction. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human LILRB4 (leukocyte immunoglobulin like receptor B4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 4.8), mammary gland adult (RPKM 4.7) and 21 other tissues See more
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Genomic context

See Lilrb4b in Genome Data Viewer
Location:
10; 10 B3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (51356708..51362425)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (51480612..51486329)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53627 Neighboring gene leukocyte immunoglobulin-like receptor subfamily A member 6 Neighboring gene predicted gene, 40645 Neighboring gene leukocyte immunoglobulin-like receptor, subfamily B, member 4A Neighboring gene predicted gene, 46224

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane receptor protein tyrosine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Fc receptor mediated inhibitory signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in mast cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of IP-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell costimulation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytotoxic T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of monocyte activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell anergy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in tolerance induction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leukocyte immunoglobulin-like receptor subfamily B member 4B
Names
glycoprotein 49 A
mast cell surface glycoprotein Gp49A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291892.1NP_001278821.1  leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of the first exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC153530, AK171573, BC065784, BY198371, BY543077
    Conserved Domains (1) summary
    cl11960
    Location:37131
    Ig; Immunoglobulin domain
  2. NM_001291893.1NP_001278822.1  leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 3 precursor

    See identical proteins and their annotated locations for NP_001278822.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC065784, BY198371, BY543077
    Consensus CDS
    CCDS88004.1
    UniProtKB/TrEMBL
    A0A1W2P7F3
    Related
    ENSMUSP00000151625.2, ENSMUST00000219661.2
    Conserved Domains (1) summary
    cl11960
    Location:29123
    Ig; Immunoglobulin domain
  3. NM_008147.2NP_032173.1  leukocyte immunoglobulin-like receptor subfamily B member 4B isoform 1 precursor

    See identical proteins and their annotated locations for NP_032173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC153530, BC065784, BY198371, BY204344, BY543077
    Consensus CDS
    CCDS23831.1
    UniProtKB/Swiss-Prot
    Q549E3, Q61450
    UniProtKB/TrEMBL
    Q549E3
    Related
    ENSMUSP00000099958.4, ENSMUST00000102894.6
    Conserved Domains (1) summary
    cl11960
    Location:124218
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    51356708..51362425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)