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KRT25 keratin 25 [ Homo sapiens (human) ]

Gene ID: 147183, updated on 8-Jul-2021

Summary

Official Symbol
KRT25provided by HGNC
Official Full Name
keratin 25provided by HGNC
Primary source
HGNC:HGNC:30839
See related
Ensembl:ENSG00000204897 MIM:616646
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARWH3; KRT25A; KRT24IRS1
Summary
This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See KRT25 in Genome Data Viewer
Location:
17q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (40748021..40755542, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38904273..38911583, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371775 Neighboring gene keratin 24 Neighboring gene keratin 223, pseudogene Neighboring gene keratin 26 Neighboring gene keratin 27

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein heterodimerization activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aging IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hair cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in intermediate filament organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type I cytoskeletal 25
Names
CK-25
K25
K25A
cytokeratin-25
keratin 25, type I
keratin-25A
type I inner root sheath specific keratin 25 irs1
type I inner root sheath-specific keratin-K25irs1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012414.1 RefSeqGene

    Range
    5002..12312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_181534.4NP_853512.1  keratin, type I cytoskeletal 25

    See identical proteins and their annotated locations for NP_853512.1

    Status: REVIEWED

    Source sequence(s)
    AJ564204, AK129503
    Consensus CDS
    CCDS11373.1
    UniProtKB/Swiss-Prot
    Q7Z3Z0
    UniProtKB/TrEMBL
    Q6ZPD6
    Related
    ENSP00000310573.4, ENST00000312150.5
    Conserved Domains (2) summary
    pfam00038
    Location:78391
    Filament; Intermediate filament protein
    cl02488
    Location:173370
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    40748021..40755542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524414.1XP_011522716.1  keratin, type I cytoskeletal 25 isoform X1

    Conserved Domains (2) summary
    pfam00038
    Location:76389
    Filament; Intermediate filament protein
    cl02488
    Location:171368
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
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