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Gnrh1 gonadotropin releasing hormone 1 [ Mus musculus (house mouse) ]

Gene ID: 14714, updated on 27-Nov-2017
Official Symbol
Gnrh1provided by MGI
Official Full Name
gonadotropin releasing hormone 1provided by MGI
Primary source
MGI:MGI:95789
See related
Ensembl:ENSMUSG00000015812
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hpg; Gnrh; LHRH; Lnrh; Gnrh2; Lhrh1
Summary
This gene encodes hypophysiotropic peptides belonging to the family of gonadotropin-releasing hormones that stimulate the release of gonadotropins and suppress secretion of prolactin from the pituitary gland. The encoded protein is proteolytically processed to generate two biologically active mature peptides. A deletional mutation encompassing the distal half of this gene in mice resulting in the loss of the encoded protein leads to hypogonadism and infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Expression
Ubiquitous expression in bladder adult (RPKM 1.8), liver E14 (RPKM 1.7) and 26 other tissues See more
Orthologs
Location:
14; 14 D1
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (67745181..67749440)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (68363286..68367493)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene cell division cycle associated 2 Neighboring gene potassium channel tetramerisation domain containing 9 Neighboring gene dedicator of cytokinesis 5 Neighboring gene microRNA 6539 Neighboring gene predicted gene, 41188

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
gonadotropin hormone-releasing hormone activity ISO
Inferred from Sequence Orthology
more info
 
hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
male sex determination ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of immature T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ethanol IDA
Inferred from Direct Assay
more info
PubMed 
response to steroid hormone IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi-associated vesicle ISO
Inferred from Sequence Orthology
more info
 
axon terminus ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic side of rough endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neurosecretory vesicle ISO
Inferred from Sequence Orthology
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
progonadoliberin-1
Names
gonadotropin releasing hormone 2
luteinizing hormone-releasing hormone I
progonadoliberin I

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008145.3NP_032171.1  progonadoliberin-1 preproprotein

    See identical proteins and their annotated locations for NP_032171.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AC093020, AK139480, CJ059442
    Consensus CDS
    CCDS27231.1
    UniProtKB/Swiss-Prot
    P13562
    UniProtKB/TrEMBL
    Q3UTE9
    Related
    ENSMUSP00000106724.2, ENSMUST00000111095.3

RNA

  1. NR_133010.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC093020, AK139480, CJ059442
    Related
    ENSMUST00000223929.1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    67745181..67749440
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518564.3XP_006518627.1  progonadoliberin-1 isoform X1

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