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Gnpat glyceronephosphate O-acyltransferase [ Mus musculus (house mouse) ]

Gene ID: 14712, updated on 5-Mar-2024

Summary

Official Symbol
Gnpatprovided by MGI
Official Full Name
glyceronephosphate O-acyltransferaseprovided by MGI
Primary source
MGI:MGI:1343460
See related
Ensembl:ENSMUSG00000031985 AllianceGenome:MGI:1343460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DHAPAT; D1Ertd819e
Summary
Enables glycerone-phosphate O-acyltransferase activity. Acts upstream of or within several processes, including cell junction assembly; cerebellum morphogenesis; and ether lipid biosynthetic process. Predicted to be located in mitochondrion and peroxisome. Predicted to be active in mitochondrial membrane and peroxisomal membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study disease of mental health and rhizomelic chondrodysplasia punctata type 2. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata type 2. Orthologous to human GNPAT (glyceronephosphate O-acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 81.3), heart adult (RPKM 49.4) and 28 other tissues See more
Orthologs
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Genomic context

See Gnpat in Genome Data Viewer
Location:
8 E2; 8 72.81 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (125589772..125616796)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (124863033..124890057)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 67 Neighboring gene RIKEN cDNA 2810004N23 gene Neighboring gene predicted gene 16163 Neighboring gene exocyst complex component 8 Neighboring gene SprT-like N-terminal domain

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycerone-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycerone-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycerone-phosphate O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables glycerone-phosphate O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisomal matrix TAS
Traceable Author Statement
more info
PubMed 
is_active_in peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dihydroxyacetone phosphate acyltransferase
Names
DAP-AT
DHAP-AT
acyl-CoA:dihydroxyacetonephosphateacyltransferase
glycerone-phosphate O-acyltransferase
NP_034452.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010322.3NP_034452.3  dihydroxyacetone phosphate acyltransferase

    See identical proteins and their annotated locations for NP_034452.3

    Status: VALIDATED

    Source sequence(s)
    AK004364, AK004771, BI990299, BY469630, BY775400
    Consensus CDS
    CCDS22776.1
    UniProtKB/Swiss-Prot
    P98192, Q9WUT6
    UniProtKB/TrEMBL
    Q3TKG9, Q3UBU1, Q545P6, Q8R390
    Related
    ENSMUSP00000034466.4, ENSMUST00000034466.10
    Conserved Domains (1) summary
    cd07993
    Location:133338
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    125589772..125616796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)