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NOTUM notum, palmitoleoyl-protein carboxylesterase [ Homo sapiens (human) ]

Gene ID: 147111, updated on 9-Dec-2024

Summary

Official Symbol
NOTUMprovided by HGNC
Official Full Name
notum, palmitoleoyl-protein carboxylesteraseprovided by HGNC
Primary source
HGNC:HGNC:27106
See related
Ensembl:ENSG00000185269 MIM:609847; AllianceGenome:HGNC:27106
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hNOTUM
Summary
Enables palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development and regulation of bone mineralization. Predicted to be located in endoplasmic reticulum lumen and extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward placenta (RPKM 82.6) See more
Orthologs
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Genomic context

See NOTUM in Genome Data Viewer
Location:
17q25.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81952507..81961187, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82819665..82828345, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79910383..79919063, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9172 Neighboring gene pyrroline-5-carboxylate reductase 1 Neighboring gene myeloid associated differentiation marker like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79906363-79906863 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79914359-79914943 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79914944-79915527 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:79917211-79917773 and GRCh37_chr17:79917774-79918336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79925163-79925740 Neighboring gene uncharacterized LOC124904087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9177 Neighboring gene uncharacterized LOC105371939 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79934117-79934890 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79934891-79935662 Neighboring gene ASPSCR1 tether for SLC2A4, UBX domain containing Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79947643-79948352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79949063-79949770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79951899-79952606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79958937-79959584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79961033-79961554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79961555-79962076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79962077-79962598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79963388-79963894 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79966024-79966524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79972873-79973594 Neighboring gene Sharpr-MPRA regulatory region 10297 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79974318-79975039

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables palmitoleyl hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables palmitoleyl hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phospholipase C activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
palmitoleoyl-protein carboxylesterase NOTUM
Names
[Wnt protein] O-palmitoleoyl-L-serine hydrolase
notum pectinacetylesterase homolog
protein notum homolog
NP_848588.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178493.6NP_848588.3  palmitoleoyl-protein carboxylesterase NOTUM precursor

    See identical proteins and their annotated locations for NP_848588.3

    Status: VALIDATED

    Source sequence(s)
    AC145207, BC036872, BC060882, BX365997
    Consensus CDS
    CCDS32771.2
    UniProtKB/Swiss-Prot
    Q6P988, Q8N410, Q8NI82
    Related
    ENSP00000387310.3, ENST00000409678.8
    Conserved Domains (1) summary
    pfam03283
    Location:82417
    PAE; Pectinacetylesterase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    81952507..81961187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    82819665..82828345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)