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NOTUM notum, palmitoleoyl-protein carboxylesterase [ Homo sapiens (human) ]

Gene ID: 147111, updated on 13-Mar-2020

Summary

Official Symbol
NOTUMprovided by HGNC
Official Full Name
notum, palmitoleoyl-protein carboxylesteraseprovided by HGNC
Primary source
HGNC:HGNC:27106
See related
Ensembl:ENSG00000185269 MIM:609847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hNOTUM
Expression
Restricted expression toward placenta (RPKM 82.6) See more
Orthologs

Genomic context

See NOTUM in Genome Data Viewer
Location:
17q25.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81952507..81961187, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79910383..79919057, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene pyrroline-5-carboxylate reductase 1 Neighboring gene myeloid associated differentiation marker like 2 Neighboring gene uncharacterized LOC105371939 Neighboring gene ASPSCR1 tether for SLC2A4, UBX domain containing

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
palmitoleyl hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
palmitoleyl hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase C activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
negative regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein depalmitoleylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein depalmitoleylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
palmitoleoyl-protein carboxylesterase NOTUM
Names
[Wnt protein] O-palmitoleoyl-L-serine hydrolase
notum pectinacetylesterase homolog
protein notum homolog
NP_848588.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178493.6NP_848588.3  palmitoleoyl-protein carboxylesterase NOTUM precursor

    See identical proteins and their annotated locations for NP_848588.3

    Status: VALIDATED

    Source sequence(s)
    AC145207, BC036872, BC060882, BX365997
    Consensus CDS
    CCDS32771.2
    UniProtKB/Swiss-Prot
    Q6P988
    Related
    ENSP00000387310.3, ENST00000409678.8
    Conserved Domains (1) summary
    pfam03283
    Location:82417
    PAE; Pectinacetylesterase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    81952507..81961187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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