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KCTD11 potassium channel tetramerization domain containing 11 [ Homo sapiens (human) ]

Gene ID: 147040, updated on 13-May-2022

Summary

Official Symbol
KCTD11provided by HGNC
Official Full Name
potassium channel tetramerization domain containing 11provided by HGNC
Primary source
HGNC:HGNC:21302
See related
Ensembl:ENSG00000213859 MIM:609848; AllianceGenome:HGNC:21302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
REN; KCASH1; C17orf36; REN/KCTD11
Summary
Enables identical protein binding activity. Predicted to be involved in positive regulation of neuron differentiation. Predicted to act upstream of or within negative regulation of neuroblast proliferation and negative regulation of smoothened signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See KCTD11 in Genome Data Viewer
Location:
17p13.1
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7352162..7354944)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7256147..7258935)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7255481..7258263)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene Sharpr-MPRA regulatory region 1992 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 Neighboring gene transmembrane protein 95 Neighboring gene TMEM256-PLSCR3 readthrough (NMD candidate) Neighboring gene tyrosine kinase non receptor 1 Neighboring gene phospholipid scramblase 3

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129844

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of growth IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
BTB/POZ domain-containing protein KCTD11
Names
RING-type E3 ubiquitin transferase subunit KCTD11
potassium channel tetramerization domain-containing protein 11
retinoic acid, EGF, NGF induced gene protein
NP_001002914.1
NP_001350571.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002914.3NP_001002914.1  BTB/POZ domain-containing protein KCTD11 s

    See identical proteins and their annotated locations for NP_001002914.1

    Status: VALIDATED

    Source sequence(s)
    AY646650, BC019929
    Consensus CDS
    CCDS32545.1
    UniProtKB/Swiss-Prot
    Q693B1
    UniProtKB/TrEMBL
    A0A158RFT7
    Related
    ENSP00000495203.1, ENST00000576980.2
    Conserved Domains (1) summary
    cl38908
    Location:165
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
  2. NM_001363642.1NP_001350571.1  BTB/POZ domain-containing protein KCTD11 l

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1b) initiates translation at an upstream AUU alternate start codon and encodes an isoform (l) with a longer N-terminus compared to isoform s. This isoform is suggested by experimental data in PMID:21237243.
    Source sequence(s)
    AC026954
    Related
    ENSP00000328352.5, ENST00000333751.8
    Conserved Domains (1) summary
    cl02518
    Location:17109
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    7352162..7354944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160020.1 Reference GRCh38.p14 PATCHES

    Range
    110527..113309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    7256147..7258935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)