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pyrF orotidine-5'-phosphate decarboxylase [ Methanothermobacter thermautotrophicus str. Delta H ]

Gene ID: 1470090, updated on 17-Apr-2022

Summary

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Gene symbol
pyrF
Gene description
orotidine-5'-phosphate decarboxylase
Locus tag
MTH_RS00570
Gene type
protein coding
Organism
Methanothermobacter thermautotrophicus str. Delta H (strain: Delta H, synonym: Methanobacterium thermoautotrophicum str. deltaH, type-material: type strain of Methanobacterium thermautotrophicum)
Lineage
Archaea; Euryarchaeota; Methanomada group; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanothermobacter
Old locus tag
MTH129; MTH_129
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Genomic context

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Location:
clone: MTH
Sequence:
NC_000916.1 (83589..84251, complement)

NC_000916.1Genomic Context describing neighboring genes Neighboring gene deoxyhypusine synthase Neighboring gene hypothetical protein Neighboring gene cobalt ECF transporter S component CbiM Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000916.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms. Toth K, et al. Biochemistry, 2009 Aug 25. PMID 19618917, Free PMC Article
  2. Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics. Smith DR, et al. J Bacteriol, 1997 Nov. PMID 9371463, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The relatively short flexible phosphate gripper loop of this enzyme from this thermophile provides a smaller enthalpic transition state stabilization, at a lower entropic price, compared to that of larger enzyme loops from the mesophiles.
    Title: An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms.
Submit: New GeneRIF Correction

General protein information

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Preferred Names
orotidine-5'-phosphate decarboxylase
WP_048060747.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000916.1 Reference assembly

    Range
    83589..84251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_048060747.1 orotidine-5'-phosphate decarboxylase [Methanothermobacter thermautotrophicus]

    Conserved Domains (1) summary
    cl21457
    Location:4 → 216
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

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