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ADRA1B adrenoceptor alpha 1B [ Homo sapiens (human) ]

Gene ID: 147, updated on 14-Jun-2020

Summary

Official Symbol
ADRA1Bprovided by HGNC
Official Full Name
adrenoceptor alpha 1Bprovided by HGNC
Primary source
HGNC:HGNC:278
See related
Ensembl:ENSG00000170214 MIM:104220
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADRA1; ALPHA1BAR
Summary
Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008]
Expression
Biased expression in spleen (RPKM 2.0), brain (RPKM 1.2) and 10 other tissues See more
Orthologs

Genomic context

See ADRA1B in Genome Data Viewer
Location:
5q33.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (159916482..159989205)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159343740..159400017)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377688 Neighboring gene long intergenic non-protein coding RNA 1847 Neighboring gene uncharacterized LOC105377689 Neighboring gene uncharacterized LOC101927790 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 40 Neighboring gene tetratricopeptide repeat domain 1 Neighboring gene PWWP domain containing 2A Neighboring gene FABP6 antisense RNA 1 Neighboring gene fatty acid binding protein 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha1-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of heart rate by epinephrine-norepinephrine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of vasoconstriction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
caveola IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
alpha-1B adrenergic receptor
Names
adrenergic, alpha-1B-, receptor
alpha-1B adrenoceptor
alpha-1B adrenoreceptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000679.4NP_000670.1  alpha-1B adrenergic receptor

    See identical proteins and their annotated locations for NP_000670.1

    Status: REVIEWED

    Source sequence(s)
    AC011343, AC068657, BQ576306, U03865
    Consensus CDS
    CCDS4347.1
    UniProtKB/Swiss-Prot
    P35368
    Related
    ENSP00000306662.3, ENST00000306675.5
    Conserved Domains (2) summary
    pfam00001
    Location:62348
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:56363
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    159916482..159989205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714821.3XP_006714884.1  alpha-1B adrenergic receptor isoform X5

    Conserved Domains (2) summary
    pfam00001
    Location:62324
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:57181
    7tm_4; Olfactory receptor
  2. XM_011534435.1XP_011532737.1  alpha-1B adrenergic receptor isoform X1

    Conserved Domains (2) summary
    pfam00001
    Location:62384
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:57181
    7tm_4; Olfactory receptor
  3. XM_005265819.2XP_005265876.1  alpha-1B adrenergic receptor isoform X6

    Conserved Domains (2) summary
    pfam00001
    Location:62314
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:57181
    7tm_4; Olfactory receptor
  4. XM_011534437.2XP_011532739.1  alpha-1B adrenergic receptor isoform X2

    Conserved Domains (2) summary
    pfam00001
    Location:62312
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:57181
    7tm_4; Olfactory receptor
  5. XM_005265818.3XP_005265875.1  alpha-1B adrenergic receptor isoform X4

    Conserved Domains (2) summary
    pfam00001
    Location:62318
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:57181
    7tm_4; Olfactory receptor
  6. XM_011534438.2XP_011532740.1  alpha-1B adrenergic receptor isoform X3

    Conserved Domains (2) summary
    pfam00001
    Location:62312
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:57181
    7tm_4; Olfactory receptor
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