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Gnb4 guanine nucleotide binding protein (G protein), beta 4 [ Mus musculus (house mouse) ]

Gene ID: 14696, updated on 14-Oct-2021

Summary

Official Symbol
Gnb4provided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), beta 4provided by MGI
Primary source
MGI:MGI:104581
See related
Ensembl:ENSMUSG00000027669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hg2b; G(beta)4; 6720453A21Rik
Expression
Broad expression in placenta adult (RPKM 17.2), CNS E18 (RPKM 11.9) and 23 other tissues See more
Orthologs
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Genomic context

See Gnb4 in Genome Data Viewer
Location:
3; 3 A3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (32632736..32670813, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (32578587..32616673, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (32482450..32515457, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 3 Neighboring gene zinc finger protein 639 Neighboring gene mitofusin 1 Neighboring gene actin-like 6A Neighboring gene mitochondrial ribosomal protein L47

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of heterotrimeric G-protein complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of heterotrimeric G-protein complex ISA
Inferred from Sequence Alignment
more info
PubMed 
located_in myelin sheath HDA PubMed 

General protein information

Preferred Names
guanine nucleotide-binding protein subunit beta-4
Names
heterotrimeric guanine nucleotide-binding protein 2b
transducin beta chain 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348062.1NP_001334991.1  guanine nucleotide-binding protein subunit beta-4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
    Source sequence(s)
    AC130281, AK036816, AK051397, BQ174397
    Consensus CDS
    CCDS17297.1
    UniProtKB/Swiss-Prot
    P29387
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
  2. NM_001348104.1NP_001335033.1  guanine nucleotide-binding protein subunit beta-4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
    Source sequence(s)
    AC130281, AK148936
    Consensus CDS
    CCDS17297.1
    UniProtKB/Swiss-Prot
    P29387
    Related
    ENSMUSP00000103869.2, ENSMUST00000108234.8
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
  3. NM_001348105.1NP_001335034.1  guanine nucleotide-binding protein subunit beta-4 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate exon in the 5' region and uses a downstream start codon compared to variant 1. It encodes isoform (2) which has a shorter N-terminus compared to isoform (1).
    Source sequence(s)
    AC130281, AK148936
    Conserved Domains (2) summary
    cd00200
    Location:12304
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:2259
    7WD40; WD40 repeat [structural motif]
  4. NM_013531.5NP_038559.2  guanine nucleotide-binding protein subunit beta-4 isoform 1

    See identical proteins and their annotated locations for NP_038559.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-3 encode the same isoform (1).
    Source sequence(s)
    AC130281, AK036816, AK051397, BQ174397
    Consensus CDS
    CCDS17297.1
    UniProtKB/Swiss-Prot
    P29387
    Related
    ENSMUSP00000121127.2, ENSMUST00000155737.8
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    32632736..32670813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535404.5XP_006535467.1  guanine nucleotide-binding protein subunit beta-4 isoform X1

    See identical proteins and their annotated locations for XP_006535467.1

    Conserved Domains (2) summary
    cd00200
    Location:8251
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1252
    7WD40; WD40 repeat [structural motif]
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