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Gnb4 guanine nucleotide binding protein (G protein), beta 4 [ Mus musculus (house mouse) ]

Gene ID: 14696, updated on 31-Jan-2019

Summary

Official Symbol
Gnb4provided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), beta 4provided by MGI
Primary source
MGI:MGI:104581
See related
Ensembl:ENSMUSG00000027669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G(beta)4; 6720453A21Rik
Expression
Broad expression in placenta adult (RPKM 17.2), CNS E18 (RPKM 11.9) and 23 other tissues See more
Orthologs

Genomic context

See Gnb4 in Genome Data Viewer
Location:
3; 3 A3
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (32580332..32616535, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (32482450..32515457, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 639 Neighboring gene mitofusin 1 Neighboring gene actin-like 6A Neighboring gene mitochondrial ribosomal protein L47

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase activity ISA
Inferred from Sequence Alignment
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell body ISO
Inferred from Sequence Orthology
more info
 
heterotrimeric G-protein complex ISA
Inferred from Sequence Alignment
more info
PubMed 
myelin sheath HDA PubMed 

General protein information

Preferred Names
guanine nucleotide-binding protein subunit beta-4
Names
transducin beta chain 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348062.1NP_001334991.1  guanine nucleotide-binding protein subunit beta-4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
    Source sequence(s)
    AC130281, AK036816, AK051397, BQ174397
    UniProtKB/Swiss-Prot
    P29387
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
  2. NM_001348104.1NP_001335033.1  guanine nucleotide-binding protein subunit beta-4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
    Source sequence(s)
    AC130281, AK148936
    UniProtKB/Swiss-Prot
    P29387
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
  3. NM_001348105.1NP_001335034.1  guanine nucleotide-binding protein subunit beta-4 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate exon in the 5' region and uses a downstream start codon compared to variant 1. It encodes isoform (2) which has a shorter N-terminus compared to isoform (1).
    Source sequence(s)
    AC130281, AK148936
    Conserved Domains (2) summary
    cd00200
    Location:12304
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:2259
    7WD40; WD40 repeat [structural motif]
  4. NM_013531.5NP_038559.2  guanine nucleotide-binding protein subunit beta-4 isoform 1

    See identical proteins and their annotated locations for NP_038559.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-3 encode the same isoform (1).
    Source sequence(s)
    AC130281, AK036816, AK051397, BQ174397
    Consensus CDS
    CCDS17297.1
    UniProtKB/Swiss-Prot
    P29387
    Related
    ENSMUSP00000121127.1, ENSMUST00000155737.7
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    32580332..32616535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535404.3XP_006535467.1  guanine nucleotide-binding protein subunit beta-4 isoform X2

    See identical proteins and their annotated locations for XP_006535467.1

    Conserved Domains (3) summary
    COG2319
    Location:1251
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:8251
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1252
    7WD40; WD40 repeat [structural motif]
  2. XM_006535403.3XP_006535466.1  guanine nucleotide-binding protein subunit beta-4 isoform X1

    See identical proteins and their annotated locations for XP_006535466.1

    UniProtKB/Swiss-Prot
    P29387
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
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