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Gnb3 guanine nucleotide binding protein (G protein), beta 3 [ Mus musculus (house mouse) ]

Gene ID: 14695, updated on 18-Sep-2024

Summary

Official Symbol
Gnb3provided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), beta 3provided by MGI
Primary source
MGI:MGI:95785
See related
Ensembl:ENSMUSG00000023439 AllianceGenome:MGI:95785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hg2d; Gnb-3
Summary
Predicted to enable GTPase binding activity; signaling receptor complex adaptor activity; and spectrin binding activity. Predicted to be involved in several processes, including cell volume homeostasis; regulation of fat cell differentiation; and regulation of lipid metabolic process. Located in dendrite. Part of heterotrimeric G-protein complex. Is expressed in several structures, including eye; ganglia; gut; liver; and spleen. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; familial hyperlipidemia; mental depression; and type 2 diabetes mellitus. Orthologous to human GNB3 (G protein subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal adult (RPKM 3.8), heart adult (RPKM 3.5) and 9 other tissues See more
Orthologs
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Genomic context

See Gnb3 in Genome Data Viewer
Location:
6 F2; 6 59.17 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124811203..124817238, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124834240..124840275, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 5 (isopeptidase T) Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124778211-124778394 Neighboring gene cell division cycle associated 3 Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene STARR-positive B cell enhancer ABC_E6487 Neighboring gene predicted gene, 32404 Neighboring gene G protein-coupled receptor 162

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activity TAS
Traceable Author Statement
more info
PubMed 
enables GTPase binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in cell volume homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell volume homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of hormone metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of hormone metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell body IEA
Inferred from Electronic Annotation
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heterotrimeric G-protein complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of heterotrimeric G-protein complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
Names
heterotrimeric guanine nucleotide-binding protein 2d
transducin beta chain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013530.1NP_038558.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

    See identical proteins and their annotated locations for NP_038558.1

    Status: VALIDATED

    Source sequence(s)
    BC018239
    Consensus CDS
    CCDS20532.1
    UniProtKB/Swiss-Prot
    Q61011
    UniProtKB/TrEMBL
    Q54AE3, Q8BMQ1
    Related
    ENSMUSP00000024206.6, ENSMUST00000024206.6
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124811203..124817238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)