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KIF18B kinesin family member 18B [ Homo sapiens (human) ]

Gene ID: 146909, updated on 8-Jul-2018
Official Symbol
KIF18Bprovided by HGNC
Official Full Name
kinesin family member 18Bprovided by HGNC
Primary source
HGNC:HGNC:27102
See related
Ensembl:ENSG00000186185 MIM:614570; Vega:OTTHUMG00000179867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in bone marrow (RPKM 3.6), lymph node (RPKM 2.4) and 14 other tissues See more
Orthologs
See KIF18B in Genome Data Viewer
Location:
17q21.31
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (44924711..44947746, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43002079..43025079, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 187 member A Neighboring gene glial fibrillary acidic protein Neighboring gene uncharacterized LOC105371793 Neighboring gene microRNA 6783 Neighboring gene complement C1q like 1 Neighboring gene basic proline-rich protein-like

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent microtubule motor activity, plus-end-directed IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
motor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell division IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
astral microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule end IDA
Inferred from Direct Assay
more info
 
microtubule plus-end IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle astral microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
kinesin-like protein KIF18B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001264573.1NP_001251503.1  kinesin-like protein KIF18B isoform 2

    See identical proteins and their annotated locations for NP_001251503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC015936, BC067365, BC144271, BX405609
    Consensus CDS
    CCDS58555.1
    UniProtKB/Swiss-Prot
    Q86Y91
    UniProtKB/TrEMBL
    A0A0C4DGP2, Q6NWY8
    Related
    ENSP00000465377.1, OTTHUMP00000262850, ENST00000587309.5, OTTHUMT00000448723
    Conserved Domains (2) summary
    smart00129
    Location:9358
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:7351
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
  2. NM_001265577.1NP_001252506.1  kinesin-like protein KIF18B isoform 1

    See identical proteins and their annotated locations for NP_001252506.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC015936, BC067365, BC136590, BX405609
    Consensus CDS
    CCDS45709.2
    UniProtKB/Swiss-Prot
    Q86Y91
    UniProtKB/TrEMBL
    A0A0C4DGP5, Q6NWY8
    Related
    ENSP00000465992.1, OTTHUMP00000262851, ENST00000593135.5, OTTHUMT00000448724
    Conserved Domains (2) summary
    smart00129
    Location:9358
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:7351
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    44924711..44947746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524386.2XP_011522688.1  kinesin-like protein KIF18B isoform X2

    Conserved Domains (2) summary
    smart00129
    Location:9358
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:7351
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
  2. XM_011524390.2XP_011522692.1  kinesin-like protein KIF18B isoform X6

    Conserved Domains (2) summary
    smart00129
    Location:18332
    KISc; Kinesin motor, catalytic domain. ATPase
    cl22853
    Location:16325
    Motor_domain; Myosin and Kinesin motor domain
  3. XM_011524388.3XP_011522690.1  kinesin-like protein KIF18B isoform X4

    Conserved Domains (2) summary
    smart00129
    Location:18367
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:16360
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
  4. XM_011524387.2XP_011522689.1  kinesin-like protein KIF18B isoform X3

    Conserved Domains (2) summary
    smart00129
    Location:18367
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:16360
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
  5. XM_011524385.2XP_011522687.1  kinesin-like protein KIF18B isoform X1

    Conserved Domains (2) summary
    smart00129
    Location:18367
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:16360
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
  6. XM_011524389.2XP_011522691.1  kinesin-like protein KIF18B isoform X5

    Conserved Domains (2) summary
    smart00129
    Location:18367
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:16360
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup
  7. XM_011524391.3XP_011522693.1  kinesin-like protein KIF18B isoform X7

    Conserved Domains (2) summary
    smart00129
    Location:18367
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01370
    Location:16360
    KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080443.1: Suppressed sequence

    Description
    NM_001080443.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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