Format

Send to:

Choose Destination

CD300LG CD300 molecule like family member g [ Homo sapiens (human) ]

Gene ID: 146894, updated on 17-Jun-2019

Summary

Official Symbol
CD300LGprovided by HGNC
Official Full Name
CD300 molecule like family member gprovided by HGNC
Primary source
HGNC:HGNC:30455
See related
Ensembl:ENSG00000161649 MIM:610520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLM9; CLM-9; TREM4; TREM-4; NEPMUCIN
Summary
Members of the CD300 (see MIM 606786)-like (CD300L) family, such as CD300LG, are widely expressed on hematopoietic cells. All CD300L proteins are type I cell surface glycoproteins that contain a single immunoglobulin (Ig) V-like domain (Takatsu et al., 2006 [PubMed 16876123]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in fat (RPKM 45.4), placenta (RPKM 12.3) and 3 other tissues See more
Orthologs

Genomic context

See CD300LG in Genome Data Viewer
Location:
17q21.31
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (43847097..43863639)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41924145..41940997)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene membrane palmitoylated protein 3 Neighboring gene uncharacterized LOC107984979 Neighboring gene uncharacterized LOC107985077 Neighboring gene membrane palmitoylated protein 2 Neighboring gene uncharacterized LOC105371787 Neighboring gene family with sequence similarity 215 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
immune system process IEA
Inferred from Electronic Annotation
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
multivesicular body membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
CMRF35-like molecule 9
Names
CD300 antigen-like family member G
triggering receptor expressed on myeloid cells 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168322.2NP_001161794.1  CMRF35-like molecule 9 isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AK309938
    Consensus CDS
    CCDS54131.1
    UniProtKB/Swiss-Prot
    Q6UXG3
    Related
    ENSP00000442368.1, ENST00000539718.5
    Conserved Domains (2) summary
    cd05716
    Location:24113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22124
    IG_like; Immunoglobulin like
  2. NM_001168323.2NP_001161795.1  CMRF35-like molecule 9 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC015937, AK298112, AK309938
    Consensus CDS
    CCDS54132.1
    UniProtKB/Swiss-Prot
    Q6UXG3
    Related
    ENSP00000366408.3, ENST00000377203.8
    Conserved Domains (2) summary
    cd05716
    Location:24113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22124
    IG_like; Immunoglobulin like
  3. NM_001168324.2NP_001161796.1  CMRF35-like molecule 9 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001161796.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC015937, AF427619
    Consensus CDS
    CCDS54133.1
    UniProtKB/Swiss-Prot
    Q6UXG3
    Related
    ENSP00000293396.7, ENST00000293396.12
    Conserved Domains (2) summary
    cd05716
    Location:24113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22124
    IG_like; Immunoglobulin like
  4. NM_145273.4NP_660316.2  CMRF35-like molecule 9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_660316.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC007993, AC015937, AK298112, AY358364, BC025395
    Consensus CDS
    CCDS11470.1
    UniProtKB/Swiss-Prot
    Q6UXG3
    Related
    ENSP00000321005.3, ENST00000317310.5
    Conserved Domains (2) summary
    cd05716
    Location:24113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22124
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    43847097..43863639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721721.3XP_006721784.1  CMRF35-like molecule 9 isoform X1

    Conserved Domains (2) summary
    cd05716
    Location:24113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22124
    IG_like; Immunoglobulin like
  2. XM_011524384.3XP_011522686.1  CMRF35-like molecule 9 isoform X4

    Conserved Domains (2) summary
    cd05716
    Location:24113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22124
    IG_like; Immunoglobulin like
  3. XM_006721722.3XP_006721785.1  CMRF35-like molecule 9 isoform X2

    Conserved Domains (2) summary
    cd05716
    Location:24113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22124
    IG_like; Immunoglobulin like
  4. XM_005257075.3XP_005257132.1  CMRF35-like molecule 9 isoform X3

    Conserved Domains (2) summary
    cd05716
    Location:24113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22124
    IG_like; Immunoglobulin like
  5. XM_005257076.3XP_005257133.1  CMRF35-like molecule 9 isoform X5

    Conserved Domains (2) summary
    cd05716
    Location:24113
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:22124
    IG_like; Immunoglobulin like
  6. XM_017024235.2XP_016879724.1  CMRF35-like molecule 9 isoform X6

RNA

  1. XR_243636.3 RNA Sequence

  2. XR_243637.3 RNA Sequence

  3. XR_243638.3 RNA Sequence

Support Center