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ODF4 outer dense fiber of sperm tails 4 [ Homo sapiens (human) ]

Gene ID: 146852, updated on 17-Jun-2019

Summary

Official Symbol
ODF4provided by HGNC
Official Full Name
outer dense fiber of sperm tails 4provided by HGNC
Primary source
HGNC:HGNC:19056
See related
Ensembl:ENSG00000184650 MIM:610097
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT134; CT136; OPPO1
Summary
This gene encodes a protein that is localized in the outer dense fibers of the tails of mature sperm. This protein is thought to have some important role in the sperm tail. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Restricted expression toward testis (RPKM 5.1) See more
Orthologs

Genomic context

See ODF4 in Genome Data Viewer
Location:
17p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8339840..8346048)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8243158..8249364)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 35 Neighboring gene RAN guanine nucleotide release factor Neighboring gene Rho guanine nucleotide exchange factor 15 Neighboring gene uncharacterized LOC100128288 Neighboring gene KRAB-A domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138215, MGC138219

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
outer dense fiber protein 4
Names
cancer/testis antigen 134
cancer/testis antigen 136
hOPPO1
outer dense fiber 4
outer dense fiber of sperm tails protein 4
testis-specific protein oppo 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319953.2NP_001306882.1  outer dense fiber protein 4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC135178
    Consensus CDS
    CCDS82069.1
    UniProtKB/TrEMBL
    C3TX97
    Related
    ENSP00000461942.1, ENST00000584943.1
  2. NM_153007.5NP_694552.2  outer dense fiber protein 4 isoform 1

    See identical proteins and their annotated locations for NP_694552.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB081120, AC135178
    Consensus CDS
    CCDS11140.1
    UniProtKB/Swiss-Prot
    Q2M2E3
    Related
    ENSP00000331086.2, ENST00000328248.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    8339840..8346048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256476.3XP_005256533.1  outer dense fiber protein 4 isoform X1

    See identical proteins and their annotated locations for XP_005256533.1

  2. XM_011523688.1XP_011521990.1  outer dense fiber protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011521990.1

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