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PIK3R6 phosphoinositide-3-kinase regulatory subunit 6 [ Homo sapiens (human) ]

Gene ID: 146850, updated on 5-Aug-2022

Summary

Official Symbol
PIK3R6provided by HGNC
Official Full Name
phosphoinositide-3-kinase regulatory subunit 6provided by HGNC
Primary source
HGNC:HGNC:27101
See related
Ensembl:ENSG00000276231 MIM:611462; AllianceGenome:HGNC:27101
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C17orf38; HsT41028; p87PIKAP; p84 PIKAP; p87(PIKAP)
Summary
Phosphoinositide 3-kinase gamma is a lipid kinase that produces the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate. The kinase is composed of a catalytic subunit and one of several regulatory subunits, and is chiefly activated by G protein-coupled receptors. This gene encodes a regulatory subunit, and is distantly related to the phosphoinositide-3-kinase, regulatory subunit 5 gene which is located adjacent to this gene on chromosome 7. The orthologous protein in the mouse binds to both the catalytic subunit and to G(beta/gamma), and mediates activation of the kinase subunit downstream of G protein-coupled receptors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Expression
Broad expression in spleen (RPKM 2.7), appendix (RPKM 1.8) and 19 other tissues See more
Orthologs
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Genomic context

See PIK3R6 in Genome Data Viewer
Location:
17p13.1
Exon count:
22
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8802722..8867677, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8708926..8774833, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8706040..8770994, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371530 Neighboring gene uncharacterized LOC124903918 Neighboring gene major facilitator superfamily domain containing 6 like Neighboring gene uncharacterized LOC107985071 Neighboring gene uncharacterized LOC124903919 Neighboring gene phosphoinositide-3-kinase regulatory subunit 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34500, DKFZp666P158

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 1-phosphatidylinositol-3-kinase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to phosphatidylinositol-4,5-bisphosphate 3-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex, class IA IC
Inferred by Curator
more info
PubMed 
part_of phosphatidylinositol 3-kinase complex, class IB ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphoinositide 3-kinase regulatory subunit 6
Names
PI3Kgamma adapter protein of 87 kDa
p84 PI3K adapter protein
p87 phosphoinositide 3-kinase gamma (PI3Kg) adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033091.1 RefSeqGene

    Range
    5004..69956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001010855.4NP_001010855.1  phosphoinositide 3-kinase regulatory subunit 6 isoform 1

    See identical proteins and their annotated locations for NP_001010855.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC003695, AC009451, KF573668
    Consensus CDS
    CCDS73985.1
    UniProtKB/Swiss-Prot
    Q5UE93, Q658R3
    UniProtKB/TrEMBL
    B3KRK9
    Related
    ENSP00000480157.1, ENST00000619866.5
    Conserved Domains (1) summary
    pfam10486
    Location:18751
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  2. NM_001290211.1NP_001277140.1  phosphoinositide 3-kinase regulatory subunit 6 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK091819, BC110301, DB326284
    UniProtKB/TrEMBL
    B3KRK9
    Conserved Domains (1) summary
    pfam10486
    Location:1615
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit

RNA

  1. NR_110865.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites at internal exons, lacks an internal exon, and contains an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC009451, AK091819, DB326284
    Related
    ENST00000613555.4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    8802722..8867677 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435450.1XP_047291406.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X10

  2. XM_047435452.1XP_047291408.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X12

  3. XM_047435444.1XP_047291400.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X4

  4. XM_047435448.1XP_047291404.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X7

  5. XM_011523678.3XP_011521980.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X3

    Conserved Domains (1) summary
    pfam10486
    Location:18540
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  6. XM_047435447.1XP_047291403.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X6

  7. XM_011523680.3XP_011521982.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X9

    Conserved Domains (1) summary
    pfam10486
    Location:18460
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  8. XM_047435451.1XP_047291407.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X11

  9. XM_011523677.3XP_011521979.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X2

    Conserved Domains (1) summary
    pfam10486
    Location:18544
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  10. XM_047435446.1XP_047291402.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X5

  11. XM_047435443.1XP_047291399.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X1

  12. XM_047435454.1XP_047291410.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X13

  13. XM_011523683.3XP_011521985.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X13

    See identical proteins and their annotated locations for XP_011521985.1

    Conserved Domains (1) summary
    pfam10486
    Location:24465
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  14. XM_047435453.1XP_047291409.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X13

  15. XM_047435457.1XP_047291413.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X15

  16. XM_011523686.3XP_011521988.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X16

    Conserved Domains (1) summary
    pfam10486
    Location:106256
    PI3K_1B_p101; Phosphoinositide 3-kinase gamma adapter protein p101 subunit
  17. XM_047435456.1XP_047291412.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X14

  18. XM_047435449.1XP_047291405.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X8

  19. XM_047435458.1XP_047291414.1  phosphoinositide 3-kinase regulatory subunit 6 isoform X17

RNA

  1. XR_007065269.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    8708926..8774833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)