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SLC47A2 solute carrier family 47 member 2 [ Homo sapiens (human) ]

Gene ID: 146802, updated on 12-Oct-2019

Summary

Official Symbol
SLC47A2provided by HGNC
Official Full Name
solute carrier family 47 member 2provided by HGNC
Primary source
HGNC:HGNC:26439
See related
Ensembl:ENSG00000180638 MIM:609833
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MATE2; MATE2K; MATE2-B; MATE2-K
Summary
This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward kidney (RPKM 17.1) See more
Orthologs

Genomic context

See SLC47A2 in Genome Data Viewer
Location:
17p11.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (19678292..19719598, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (19581626..19622990, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MT-CO1 pseudogene 39 Neighboring gene aldehyde dehydrogenase 3 family member A2 Neighboring gene aldehyde dehydrogenase 3 family member A1 Neighboring gene TBC1 domain family member 25 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

General gene information

Homology

Clone Names

  • FLJ31196

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antiporter activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
xenobiotic transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
transmembrane transport TAS
Traceable Author Statement
more info
 
xenobiotic transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
multidrug and toxin extrusion protein 2
Names
kidney-specific H(+)/organic cation antiporter
solute carrier family 47 (multidrug and toxin extrusion), member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052805.1 RefSeqGene

    Range
    7396..45688
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001099646.2NP_001093116.1  multidrug and toxin extrusion protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001093116.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2, also known as MATE2-K), compared to isoform 1.
    Source sequence(s)
    AB250364, AC005722
    UniProtKB/Swiss-Prot
    Q86VL8
    Conserved Domains (2) summary
    COG0534
    Location:33467
    NorM; Na+-driven multidrug efflux pump [Defense mechanisms]
    cd13132
    Location:30464
    MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
  2. NM_001256663.2NP_001243592.1  multidrug and toxin extrusion protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001243592.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site and contains an alternate in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AB250364, AC005722, BC035288, DA312379
    Consensus CDS
    CCDS58530.1
    UniProtKB/Swiss-Prot
    Q86VL8
    Related
    ENSP00000338084.6, ENST00000350657.9
    Conserved Domains (2) summary
    COG0534
    Location:33481
    NorM; Na+-driven multidrug efflux pump [Defense mechanisms]
    cd13132
    Location:30478
    MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
  3. NM_152908.4NP_690872.2  multidrug and toxin extrusion protein 2 isoform 1

    See identical proteins and their annotated locations for NP_690872.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1), also known as MATE2.
    Source sequence(s)
    AC005722, BC050578
    Consensus CDS
    CCDS11211.1
    UniProtKB/Swiss-Prot
    Q86VL8
    Related
    ENSP00000326671.5, ENST00000325411.9
    Conserved Domains (2) summary
    COG0534
    Location:33503
    NorM; Na+-driven multidrug efflux pump [Defense mechanisms]
    cd13132
    Location:30500
    MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

RNA

  1. NR_135624.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB250364, BC035288, BX648861
    Related
    ENST00000463318.5
  2. NR_135625.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB250701, AC005722, AK307647, BC035288
    Related
    ENST00000574239.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    19678292..19719598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024221.1XP_016879710.1  multidrug and toxin extrusion protein 2 isoform X1

  2. XM_017024222.2XP_016879711.1  multidrug and toxin extrusion protein 2 isoform X2

  3. XM_017024223.1XP_016879712.1  multidrug and toxin extrusion protein 2 isoform X3

  4. XM_017024224.1XP_016879713.1  multidrug and toxin extrusion protein 2 isoform X4

    Related
    ENSP00000391848.2, ENST00000433844.2
  5. XM_017024226.1XP_016879715.1  multidrug and toxin extrusion protein 2 isoform X6

  6. XM_017024225.1XP_016879714.1  multidrug and toxin extrusion protein 2 isoform X5

RNA

  1. XR_001752432.1 RNA Sequence

  2. XR_001752433.1 RNA Sequence

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