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Gna12 guanine nucleotide binding protein, alpha 12 [ Mus musculus (house mouse) ]

Gene ID: 14673, updated on 5-Mar-2019

Summary

Official Symbol
Gna12provided by MGI
Official Full Name
guanine nucleotide binding protein, alpha 12provided by MGI
Primary source
MGI:MGI:95767
See related
Ensembl:ENSMUSG00000000149
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI414047; AI504261; Galpha12
Expression
Ubiquitous expression in adrenal adult (RPKM 67.3), ovary adult (RPKM 61.7) and 28 other tissues See more
Orthologs

Genomic context

See Gna12 in Genome Data Viewer
Location:
5 G2; 5 79.3 cM
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (140759944..140830431, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (141235898..141306385, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene BRCA1-associated ATM activator 1 Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene predicted gene, 30745 Neighboring gene predicted gene, 30804 Neighboring gene caspase recruitment domain family, member 11 Neighboring gene predicted gene, 38729

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Amz1

Homology

Clone Names

  • MGC130498

Gene Ontology Provided by MGI

Function Evidence Code Pubs
D5 dopamine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
D5 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity ISA
Inferred from Sequence Alignment
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
PubMed 
guanyl nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway ISA
Inferred from Sequence Alignment
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
embryonic digit morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
brush border membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brush border membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heterotrimeric G-protein complex TAS
Traceable Author Statement
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein subunit alpha-12
Names
G-protein subunit alpha-12
g alpha-12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010302.2NP_034432.1  guanine nucleotide-binding protein subunit alpha-12

    See identical proteins and their annotated locations for NP_034432.1

    Status: PROVISIONAL

    Source sequence(s)
    AC158914
    Consensus CDS
    CCDS19825.1
    UniProtKB/Swiss-Prot
    P27600
    Related
    ENSMUSP00000000153.4, ENSMUST00000000153.8
    Conserved Domains (1) summary
    smart00275
    Location:40377
    G_alpha; G protein alpha subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    140759944..140830431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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