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B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1 [ Homo sapiens (human) ]

Gene ID: 146712, updated on 1-Jun-2020

Summary

Official Symbol
B3GNTL1provided by HGNC
Official Full Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1provided by HGNC
Primary source
HGNC:HGNC:21727
See related
Ensembl:ENSG00000175711 MIM:615337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B3GNT8; BGnT-8; beta-1; 3-Gn-T8; beta3Gn-T8; beta3GnTL1
Expression
Ubiquitous expression in bone marrow (RPKM 1.9), skin (RPKM 1.8) and 25 other tissues See more
Orthologs

Genomic context

See B3GNTL1 in Genome Data Viewer
Location:
17q25.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (82942149..83051845, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80900009..81009686, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tubulin folding cofactor D Neighboring gene zinc finger protein 750 Neighboring gene TBCD intron CAGE-defined B cell enhancer Neighboring gene uncharacterized LOC107987251 Neighboring gene meteorin like, glial cell differentiation regulator

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126253, MGC126256

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transferase activity, transferring glycosyl groups IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1
Names
BGnT-like protein 1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
beta-1,3-Gn-T8
beta-1,3-N-acetylglucosaminyltransferase 8
beta1,3-N-acetylglucosaminyltransferase-like protein 1
beta3Gn-T-like protein 1
NP_001009905.1
NP_001307671.1
NP_001307672.1
XP_006722335.1
XP_006722337.2
XP_011521834.1
XP_016879696.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009905.2NP_001009905.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_001009905.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AA764879, AC130371, AY634364, BU623325
    Consensus CDS
    CCDS32778.1
    UniProtKB/Swiss-Prot
    Q67FW5
    UniProtKB/TrEMBL
    A0A024R8X6
    Related
    ENSP00000319979.3, ENST00000320865.3
    Conserved Domains (2) summary
    cd06913
    Location:22240
    beta3GnTL1_like; Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine
    COG0463
    Location:16253
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
  2. NM_001320742.2NP_001307671.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon, resulting in a novel 5' UTR and the use of an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus, and is shorter than isoform a.
    Source sequence(s)
    AC130371
    Conserved Domains (2) summary
    cd06913
    Location:8226
    beta3GnTL1_like; Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine
    COG0463
    Location:7239
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
  3. NM_001320743.1NP_001307672.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (c) with a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC130371
    Consensus CDS
    CCDS82232.1
    UniProtKB/TrEMBL
    I3L232
    Related
    ENSP00000459327.1, ENST00000572977.5
    Conserved Domains (1) summary
    cl11394
    Location:162
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RNA

  1. NR_135465.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC130371
  2. NR_135466.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the use of an alternate promoter and differs in the 5' and 3' structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA764879, AK054757, DA405237

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    82942149..83051845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523532.2XP_011521834.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 isoform X2

    Conserved Domains (2) summary
    cd06913
    Location:22218
    beta3GnTL1_like; Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine
    COG0463
    Location:16114
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
  2. XM_006722272.3XP_006722335.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006722335.1

    UniProtKB/Swiss-Prot
    Q67FW5
    UniProtKB/TrEMBL
    A0A024R8X6
    Conserved Domains (2) summary
    cd06913
    Location:22240
    beta3GnTL1_like; Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine
    COG0463
    Location:16253
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
  3. XM_006722274.2XP_006722337.2  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 isoform X3

    Conserved Domains (2) summary
    COG0463
    Location:16129
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cl11394
    Location:22141
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  4. XM_017024207.1XP_016879696.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 isoform X4

RNA

  1. XR_001752429.1 RNA Sequence

  2. XR_002957964.1 RNA Sequence

  3. XR_002957963.1 RNA Sequence

  4. XR_002957966.1 RNA Sequence

  5. XR_002957968.1 RNA Sequence

  6. XR_933928.2 RNA Sequence

  7. XR_002957967.1 RNA Sequence

  8. XR_002957962.1 RNA Sequence

  9. XR_001752430.1 RNA Sequence

  10. XR_001752431.1 RNA Sequence

  11. XR_002957965.1 RNA Sequence

  12. XR_002957970.1 RNA Sequence

  13. XR_002957971.1 RNA Sequence

  14. XR_002957969.1 RNA Sequence

  15. XR_933927.2 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187612.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    51111..159276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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