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TEPSIN TEPSIN adaptor related protein complex 4 accessory protein [ Homo sapiens (human) ]

Gene ID: 146705, updated on 12-Aug-2022

Summary

Official Symbol
TEPSINprovided by HGNC
Official Full Name
TEPSIN adaptor related protein complex 4 accessory proteinprovided by HGNC
Primary source
HGNC:HGNC:26458
See related
Ensembl:ENSG00000167302 AllianceGenome:HGNC:26458
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ENTHD2; C17orf56
Summary
Located in coated vesicle membrane; nucleus; and trans-Golgi network membrane. Is extrinsic component of organelle membrane. Colocalizes with AP-4 adaptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 10.7), bone marrow (RPKM 9.4) and 25 other tissues See more
Orthologs
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Genomic context

See TEPSIN in Genome Data Viewer
Location:
17q25.3
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81228277..81239055, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82137400..82148178, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79202077..79212855, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene apoptosis associated tyrosine kinase Neighboring gene parvalbumin like EF-hand containing Neighboring gene centrosomal protein 131 Neighboring gene uncharacterized LOC105371925 Neighboring gene uncharacterized LOC124904081 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 8 Neighboring gene solute carrier family 38 member 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ31528, DKFZp451M1616

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in coated vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in extrinsic component of organelle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extrinsic component of organelle membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
is_active_in trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
AP-4 complex accessory subunit tepsin
Names
AP-4 accessory protein
ENTH domain containing 2
ENTH domain-containing protein 2
epsin for AP-4
tetra-epsin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363764.2NP_001350693.1  AP-4 complex accessory subunit tepsin isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC027601
    Consensus CDS
    CCDS86648.1
    UniProtKB/TrEMBL
    A0A1B0GV70
    Related
    ENSP00000490393.1, ENST00000637944.2
    Conserved Domains (2) summary
    cd03572
    Location:15136
    ENTH_epsin_related; ENTH domain, Epsin Related family; composed of hypothetical proteins containing an ENTH-like domain. The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in ...
    cl28033
    Location:425586
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  2. NM_144679.3NP_653280.1  AP-4 complex accessory subunit tepsin isoform 2

    See identical proteins and their annotated locations for NP_653280.1

    Status: VALIDATED

    Source sequence(s)
    AC027601, AK056090, BC037231
    Consensus CDS
    CCDS11779.1
    UniProtKB/Swiss-Prot
    Q6ZSQ9, Q96N21
    Related
    ENSP00000300714.3, ENST00000300714.7
    Conserved Domains (2) summary
    cd03572
    Location:15136
    ENTH_epsin_related; ENTH domain, Epsin Related family; composed of hypothetical proteins containing an ENTH-like domain. The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in ...
    cl28033
    Location:357518
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    81228277..81239055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721709.4XP_006721772.1  AP-4 complex accessory subunit tepsin isoform X6

    Conserved Domains (1) summary
    cd03572
    Location:15138
    ENTH_epsin_related; ENTH domain, Epsin Related family; composed of hypothetical proteins containing an ENTH-like domain. The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in ...
  2. XM_047435391.1XP_047291347.1  AP-4 complex accessory subunit tepsin isoform X5

  3. XM_047435390.1XP_047291346.1  AP-4 complex accessory subunit tepsin isoform X4

  4. XM_005257066.2XP_005257123.1  AP-4 complex accessory subunit tepsin isoform X2

    Conserved Domains (1) summary
    cd03572
    Location:227346
    ENTH_epsin_related; ENTH domain, Epsin Related family; composed of hypothetical proteins containing an ENTH-like domain. The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in ...
  5. XM_011524356.1XP_011522658.1  AP-4 complex accessory subunit tepsin isoform X3

    Conserved Domains (1) summary
    cd03572
    Location:227348
    ENTH_epsin_related; ENTH domain, Epsin Related family; composed of hypothetical proteins containing an ENTH-like domain. The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in ...
  6. XM_011524355.1XP_011522657.1  AP-4 complex accessory subunit tepsin isoform X1

    Conserved Domains (1) summary
    cd03572
    Location:227348
    ENTH_epsin_related; ENTH domain, Epsin Related family; composed of hypothetical proteins containing an ENTH-like domain. The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in ...
  7. XM_017024204.3XP_016879693.1  AP-4 complex accessory subunit tepsin isoform X7

    Conserved Domains (1) summary
    cd03572
    Location:9131
    ENTH_epsin_related; ENTH domain, Epsin Related family; composed of hypothetical proteins containing an ENTH-like domain. The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in ...
  8. XM_011524357.2XP_011522659.1  AP-4 complex accessory subunit tepsin isoform X7

    See identical proteins and their annotated locations for XP_011522659.1

    Conserved Domains (1) summary
    cd03572
    Location:9131
    ENTH_epsin_related; ENTH domain, Epsin Related family; composed of hypothetical proteins containing an ENTH-like domain. The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    82137400..82148178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)