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Glud1 glutamate dehydrogenase 1 [ Mus musculus (house mouse) ]

Gene ID: 14661, updated on 8-Jan-2023

Summary

Official Symbol
Glud1provided by MGI
Official Full Name
glutamate dehydrogenase 1provided by MGI
Primary source
MGI:MGI:95753
See related
Ensembl:ENSMUSG00000021794 AllianceGenome:MGI:95753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glud; Gdh-X; Gludl
Summary
Enables glutamate dehydrogenase (NAD+) activity. Involved in glutamine metabolic process and tricarboxylic acid metabolic process. Acts upstream of or within positive regulation of insulin secretion. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 6; hyperinsulinism; hypoglycemia; and late onset Parkinson's disease. Orthologous to several human genes including GLUD1 (glutamate dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 291.2), liver E18 (RPKM 185.4) and 27 other tissues See more
Orthologs
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Genomic context

See Glud1 in Genome Data Viewer
Location:
14 B; 14 20.8 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (34032684..34066990)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34310727..34345033)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene synaptotagmin XV Neighboring gene shieldin complex subunit 2 Neighboring gene zinc finger, DHHC domain containing 17 pseudogene Neighboring gene B-cell CLL/lymphoma 7C pseudogene Neighboring gene family with sequence similarity 25, member A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP binding ISO
Inferred from Sequence Orthology
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables NAD+ binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables glutamate dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutamate dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutamate dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate dehydrogenase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutamate dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
 
enables leucine binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glutamate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glutamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of insulin secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to aluminum ion ISO
Inferred from Sequence Orthology
more info
 
involved_in tricarboxylic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate dehydrogenase 1, mitochondrial
Names
GDH 1
NP_032159.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008133.4NP_032159.1  glutamate dehydrogenase 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_032159.1

    Status: VALIDATED

    Source sequence(s)
    AK089152, AK150637, AK161876
    Consensus CDS
    CCDS26935.1
    UniProtKB/Swiss-Prot
    P26443, Q8C273
    UniProtKB/TrEMBL
    A0A6P5R1P7, A0A8C6N3Z3, Q3TSQ7
    Related
    ENSMUSP00000022322.10, ENSMUST00000022322.17
    Conserved Domains (1) summary
    COG0334
    Location:104546
    GdhA; Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    34032684..34066990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)