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DNAAF8 dynein axonemal assembly factor 8 [ Homo sapiens (human) ]

Gene ID: 146562, updated on 10-Dec-2024

Summary

Official Symbol
DNAAF8provided by HGNC
Official Full Name
dynein axonemal assembly factor 8provided by HGNC
Primary source
HGNC:HGNC:25081
See related
Ensembl:ENSG00000166246 AllianceGenome:HGNC:25081
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Daap1; C16orf71
Summary
Predicted to enable dynein complex binding activity. Predicted to be involved in outer dynein arm assembly. Located in dynein axonemal particle. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward testis (RPKM 29.4) See more
Orthologs
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Genomic context

See DNAAF8 in Genome Data Viewer
Location:
16p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (4734537..4749396)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (4763994..4778854)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4784538..4799397)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene hESC enhancers GRCh37_chr16:4743475-4743982 and GRCh37_chr16:4743983-4744490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:4745093-4745593 Neighboring gene nudix hydrolase 16 like 1 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 3 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr16:4763641-4764282 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr16:4764283-4764922 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr16:4768049-4768651 and GRCh37_chr16:4768652-4769253 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7163 Neighboring gene zinc finger protein 500 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10344 Neighboring gene septin 12 Neighboring gene small integral membrane protein 22 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:4852142-4852642 Neighboring gene rogdi atypical leucine zipper

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ43261, DKFZp686H2240

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dynein complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in outer dynein arm assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in dynein axonemal particle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dynein axonemal particle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dynein axonemal assembly factor 8
Names
dynein axonemal-associated protein 1
uncharacterized protein C16orf71

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139170.3NP_631909.2  dynein axonemal assembly factor 8

    See identical proteins and their annotated locations for NP_631909.2

    Status: VALIDATED

    Source sequence(s)
    BC035024, BI458862, BX648126
    Consensus CDS
    CCDS10521.1
    UniProtKB/Swiss-Prot
    Q8IYS4, Q8NCV0
    UniProtKB/TrEMBL
    K7EPW6
    Related
    ENSP00000299320.4, ENST00000299320.10
    Conserved Domains (1) summary
    pfam15773
    Location:21520
    DUF4701; Domain of unknown function (DUF4701)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    4734537..4749396
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005255144.4XP_005255201.1  dynein axonemal assembly factor 8 isoform X2

    Conserved Domains (1) summary
    pfam15773
    Location:1382
    DUF4701; Domain of unknown function (DUF4701)
  2. XM_017022975.2XP_016878464.1  dynein axonemal assembly factor 8 isoform X1

    UniProtKB/TrEMBL
    K7EPW6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    4763994..4778854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379690.1XP_054235665.1  dynein axonemal assembly factor 8 isoform X2

  2. XM_054379689.1XP_054235664.1  dynein axonemal assembly factor 8 isoform X1

    UniProtKB/TrEMBL
    K7EPW6